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Talk:Etazene: Difference between revisions
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{{SubstanceBox/Etodesnitazene}} | |||
'''Etodesnitazene''' (Desnitroetonitazene, Etazen, '''Etazene''', Etazone) is a benzimidazole derived [[opioid]] [[analgesic]] drug, which was originally developed in the late 1950s alongside [[etonitazene]] and a range of related derivatives.<ref>Vandeputte M, et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of nitazene new synthetic opioids. Authorea. November 12, 2020. doi:10.22541/au.160520665.59016513/v1</ref> It is many times less potent than [[etonitazene]] itself, but still 70x more potent than [[morphine]] in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by [[piperidine]] or [[pyrrolidine]] rings also retain significant activity (10x and 20x morphine respectively).<ref>Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol‐Derivate und verwandte Heterocyclen. II. Synthese von 1‐Aminoalkyl‐2‐benzyl‐benzimidazolen". Helvetica Chimica Acta (in German). 43 (3): 800–809. doi:10.1002/hlca.19600430323.</ref> | '''Etodesnitazene''' (Desnitroetonitazene, Etazen, '''Etazene''', Etazone) is a benzimidazole derived [[opioid]] [[analgesic]] drug, which was originally developed in the late 1950s alongside [[etonitazene]] and a range of related derivatives.<ref>Vandeputte M, et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of nitazene new synthetic opioids. Authorea. November 12, 2020. doi:10.22541/au.160520665.59016513/v1</ref> It is many times less potent than [[etonitazene]] itself, but still 70x more potent than [[morphine]] in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by [[piperidine]] or [[pyrrolidine]] rings also retain significant activity (10x and 20x morphine respectively).<ref>Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol‐Derivate und verwandte Heterocyclen. II. Synthese von 1‐Aminoalkyl‐2‐benzyl‐benzimidazolen". Helvetica Chimica Acta (in German). 43 (3): 800–809. doi:10.1002/hlca.19600430323.</ref> | ||