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MXiPr: Difference between revisions
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{{SubstanceBox/MXiPr}} | {{SubstanceBox/MXiPr}} | ||
'''2-(Isopropylamino)-2-(3-methoxyphenyl)cyclohexanone''' (also known as '''3-MeO-2′-Oxo-PCiPr''' and '''MXiPr''') is a novel [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class. It is a structural analog of [[MXE]]. | |||
The circumstances surrounding MXiPr's original discovery are not known and its synthesis has not documented in the scientific literature. MXiPr first appeared on the online research chemical market in late 2020<ref>MXiPr - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=MXiPr</ref> and was marketed as a legal substitute for [[ketamine]] or [[MXE]]. The initial batch reportedly smelled like plastic and was suspected of containing impurities. | |||
[[Subjective effects]] are comparable to ketamine and include [[sedation]], [[motor control loss]], [[pain relief]], [[internal hallucinations]], [[conceptual thinking]], [[euphoria]], and [[disconnective effects|dissociation]]. Early anecdotal reports suggest that MXiPr exhibits two plateaus. The first plateau occurs at doses around 5-20 mg and produces a two hour long experience resembling nitrous oxide. The second plateau at doses around 20-40+ mg giving an experience similar to a ketamine k-hole, with a warmer or "dreamier" afterglow. It is not known if higher plateaus exist, and some researchers have urged caution if experimenting with higher doses. There are reports of body load occurring for up to 2 days after a small dose. | |||
Very little data exists about the pharmacological properties, metabolism, and toxicity of MXiPr, and it has a very brief history of human usage. Given the reports of impure batches, it is advised to purify this substance before use (please see [[MXiPr#Toxicity and harm potential|this section]] for more details). It is strongly recommended to use [[harm reduction practices]] if using this substance. | |||
Very little data exists about the pharmacological properties, metabolism, and toxicity of MXiPr, and it has a very brief history of human usage. It is strongly recommended | |||
==History and culture== | ==History and culture== | ||
MXiPr first appeared for sale on the online research chemical market in late 2020.<ref>MXiPr - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=MXiPr</ref> | |||
==Chemistry== | ==Chemistry== | ||
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==Subjective effects== | ==Subjective effects== | ||
{{EffectStub}} | |||
MXiPr can be said to share similar properties to that of [[MXE]] or [[O-PCE]] but there have been some anecdotal reports that suggest that this may have a potentially higher risk of inducing [[wikipedia:Rhabdomyolysis| Rhabdomyolysis (Wikipedia)]], seizures, and amnesia. It is possible that these effects may be avoided by practicing harm reduction via keeping dosages low, usage infrequent, and avoiding combinations. | |||
{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
{{effects/base | {{effects/base | ||
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*'''[[Effect::Spontaneous bodily sensations]]''' - The MXiPr "body high" can be described as a sharp, pleasurable tingling sensation which is location specific to the hands, feet, and head. | *'''[[Effect::Spontaneous bodily sensations]]''' - The MXiPr "body high" can be described as a sharp, pleasurable tingling sensation which is location specific to the hands, feet, and head. | ||
*'''[[Effect::Perception of bodily lightness]]''' - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate doses by making the body feel light and effortless to move. | *'''[[Effect::Perception of bodily lightness]]''' - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate doses by making the body feel light and effortless to move. | ||
*'''[[Effect::Motor control loss]]''' - A loss of gross and fine motor control alongside balance and coordination is prevalent | *'''[[Effect::Motor control loss]]''' - A loss of gross and fine motor control alongside balance and coordination is prevalent on MXiPr and becomes especially strong at higher doses. This means that one should be sitting down before the onset (unless experienced) in the case of falling over and injuring oneself. | ||
*'''[[Effect::Spatial disorientation]] | *'''[[Effect::Spatial disorientation]] | ||
*'''[[Effect::Tactile suppression]]''' - This partially to entirely suppresses one's sense of touch, creating feelings of numbness within the extremities. It is responsible for the anesthetic properties of this substance. | *'''[[Effect::Tactile suppression]]''' - This partially to entirely suppresses one's sense of touch, creating feelings of numbness within the extremities. It is responsible for the anesthetic properties of this substance. | ||
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*'''[[Effect::Creativity enhancement]]''' | *'''[[Effect::Creativity enhancement]]''' | ||
*'''[[Effect::Déjà vu]]''' | *'''[[Effect::Déjà vu]]''' | ||
*'''[[Effect::Mania]]''' - Some users have reported mania on this | *'''[[Effect::Mania]]''' - Some users have reported mania on this substance. The frequency of which is undetermined. It is strongly recommended to use harm-reduction practices and not use this substance in high amounts or frequently. Most likely, it is more common than most [[arylcyclohexylamines]] but less common in occurrence compared to PCP and 3-MeO-PCP. | ||
*'''[[Effect::Depersonalization]]''' & '''[[Effect::Derealization]]''' | *'''[[Effect::Depersonalization]]''' & '''[[Effect::Derealization]]''' | ||
*'''[[Effect::Delusion]]''' - Most likely, it is more common than most [[arylcyclohexylamines]] but less common in occurrence compared to drugs like 3-MeO-PCP. | *'''[[Effect::Delusion]]''' - Most likely, it is more common than most [[arylcyclohexylamines]] but less common in occurrence compared to drugs like 3-MeO-PCP. | ||
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{{effects/auditory| | {{effects/auditory| | ||
The auditory effects | The auditory effects of MXiPr have been described as more pronounced than other hallucinogens. These effects include: | ||
*'''[[Effect::Auditory distortion|Distortions]]''' - These distortions are very powerful and loud enough in their volume to make the original sound completely unrecognizable. They include phasers, white noise, high pitch tones and notes, flanging, changes in pitch, echo effects, and stuttering. In particular, the frequency of the stuttering is proportionally related to the intensity of the effects, especially ego death which occurs when the stuttering becomes continuous. | *'''[[Effect::Auditory distortion|Distortions]]''' - These distortions are very powerful and loud enough in their volume to make the original sound completely unrecognizable. They include phasers, white noise, high pitch tones and notes, flanging, changes in pitch, echo effects, and stuttering. In particular, the frequency of the stuttering is proportionally related to the intensity of the effects, especially ego death which occurs when the stuttering becomes continuous. | ||
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*'''[[Effect::Visual disconnection]]''' - This eventually results in MXiPr's equivalent of the "[https://en.wikipedia.org/wiki/K-hole k-hole]" or, more specifically, ''[[Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Visual disconnection#Structures|structures]]''. | *'''[[Effect::Visual disconnection]]''' - This eventually results in MXiPr's equivalent of the "[https://en.wikipedia.org/wiki/K-hole k-hole]" or, more specifically, ''[[Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Visual disconnection#Structures|structures]]''. | ||
*'''[[Effect::Consciousness disconnection]]''' | *'''[[Effect::Consciousness disconnection]]''' | ||
}} | }} | ||
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* [https://www.erowid.org/experiences/subs/exp_MXiPr.shtml Erowid Experience Vaults: MXiPr] <!-- Check the link to see if it exists --> | * [https://www.erowid.org/experiences/subs/exp_MXiPr.shtml Erowid Experience Vaults: MXiPr] <!-- Check the link to see if it exists --> | ||
* [https://www.reddit.com/r/researchchemicals/comments/la97rf/mxipr_consistently_gives_seizures_at_higher/ Reddit: MXiPr consistently gives seizures at higher dosages administered IM] | * [https://www.reddit.com/r/researchchemicals/comments/la97rf/mxipr_consistently_gives_seizures_at_higher/ Reddit: MXiPr consistently gives seizures at higher dosages administered IM] | ||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{toxicity}} | {{toxicity}} | ||
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}} | |||
The toxicity and long-term health effects of recreational MXiPr use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because MXiPr has very little history of human usage. | |||
If one suspects that it may be impure and are still keen on taking this substance, at the very least ensure that it to goes through first-pass metabolism by taking it orally. | |||
It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance. | It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance. | ||
=== | ===Dependence and abuse potential=== | ||
As with other NMDA receptor antagonists, the chronic use of MXiPr can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of producing psychological dependence among certain users. | |||
When addiction has developed, cravings and [[withdrawal effects]] may occur if one suddenly stops their usage. | |||
Tolerance to many of the effects of MXiPr [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. | |||
After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). | |||
MXiPr exhibits cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of MXiPr all [[dissociative]]s will have a reduced effect. | |||
===Urinary tract effects=== | ===Urinary tract effects=== | ||
Regarding its long-term health effects when used repeatedly and over excessive periods, MXiPr | Regarding its long-term health effects when used repeatedly and over excessive periods, MXiPr is suspected to exhibit similar bladder and urinary tract problems found with [[ketamine]], but to a lesser extent. This is because MXiPr is far more potent than ketamine, so significantly less of substance needs to be consumed. Symptoms of ketamine-induced cystitis can become severe and can be described as: | ||
*'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes. | *'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes. | ||
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==External links== | ==External links== | ||
[https://www.bluelight.org/xf/threads/the-big-dandy-3-meo-2%E2%80%B2-oxo-pcipr-mxipr-thread.889817/ Bluelight - The Big & Dandy 3-MeO-2′-oxo-PCiPr (MXiPr) Thread] | *[https://www.bluelight.org/xf/threads/the-big-dandy-3-meo-2%E2%80%B2-oxo-pcipr-mxipr-thread.889817/ Bluelight - The Big & Dandy 3-MeO-2′-oxo-PCiPr (MXiPr) Thread] | ||
==References== | ==References== | ||