DMT: Difference between revisions - PsychonautWiki Archive

Line 39:

In addition to this, N,N-dimethyltryptamine is believed to be an endogenous ligand for the sigma receptor. However, the significance of the sigma-1 receptor remains the subject of ongoing scientific research.<ref>{{cite journal|last1=Fontanilla|first1=D.|last2=Johannessen|first2=M.|last3=Hajipour|first3=A. R.|last4=Cozzi|first4=N. V.|last5=Jackson|first5=M. B.|last6=Ruoho|first6=A. E.|title=The Hallucinogen ''N'',''N''-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator|year=2009|journal=Science|issn=0036-8075|eissn=1095-9203|oclc=1644869|volume=323|issue=5916|pages=934-937|doi=10.1126/science.1166127|pmid=19213917|pmc=2947205}}</ref>

~~===Route of administration===~~

* Oral: Oral [[DMT]] is inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, DMT is frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]]. When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]].<ref>{{cite journal|last=Strassman|first=Rick J.|title=Human psychopharmacology of N,N-dimethyltryptamine|year=1995|journal=Behavioural Brain Research|volume=73|issue=1-2|pages=121-124|doi=10.1016/0166-4328(96)00081-2|issn=0166-4328|eissn=1872-7549|oclc=06183451}}</ref> Ayahuasca brews have been used traditionally in South America since at least around the year 1500.<ref>{{cite web|url=http://www.erowid.org/chemicals/dmt/dmt_basics.shtml|publisher=Erowid|title=Erowid DMT Vault: Basics|access-date=January 7, 2020|date=August 22, 2000}}</ref>

* Insufflation (snorting): DMT absorbed through the nose may drip down your throat and be swallowed. If swallowed, it will be broken down in your stomach and have no effect.

===Variety of DMT methods and routes of administration===

Line 65:

Line 61:

**Intravenous injection of DMT crystals (from 4 to 20 mg; unknown duration, assumed higher than that of intravenous DMT without prior harmalas ingestion)

**Intramuscular injection of DMT crystals (up to 80 mg; unknown duration, assumed higher than that of intramuscular DMT without prior harmalas ingestion)

====Limitations====

* Oral: Oral [[DMT]] is inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, DMT is frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]]. When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]].<ref>{{cite journal|last=Strassman|first=Rick J.|title=Human psychopharmacology of N,N-dimethyltryptamine|year=1995|journal=Behavioural Brain Research|volume=73|issue=1-2|pages=121-124|doi=10.1016/0166-4328(96)00081-2|issn=0166-4328|eissn=1872-7549|oclc=06183451}}</ref> Ayahuasca brews have been used traditionally in South America since at least around the year 1500.<ref>{{cite web|url=http://www.erowid.org/chemicals/dmt/dmt_basics.shtml|publisher=Erowid|title=Erowid DMT Vault: Basics|access-date=January 7, 2020|date=August 22, 2000}}</ref>

* Insufflation (snorting): DMT absorbed through the nose may drip down your throat and be swallowed. If swallowed, it will be broken down in your stomach and have no effect.

==Subjective effects==

@@ Line 39: / Line 39: @@
 In addition to this, N,N-dimethyltryptamine is believed to be an endogenous ligand for the sigma receptor. However, the significance of the sigma-1 receptor remains the subject of ongoing scientific research.<ref>{{cite journal|last1=Fontanilla|first1=D.|last2=Johannessen|first2=M.|last3=Hajipour|first3=A. R.|last4=Cozzi|first4=N. V.|last5=Jackson|first5=M. B.|last6=Ruoho|first6=A. E.|title=The Hallucinogen ''N'',''N''-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator|year=2009|journal=Science|issn=0036-8075|eissn=1095-9203|oclc=1644869|volume=323|issue=5916|pages=934-937|doi=10.1126/science.1166127|pmid=19213917|pmc=2947205}}</ref>
-===Route of administration===
-* Oral: Oral [[DMT]] is inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, DMT is frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]]. When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]].<ref>{{cite journal|last=Strassman|first=Rick J.|title=Human psychopharmacology of N,N-dimethyltryptamine|year=1995|journal=Behavioural Brain Research|volume=73|issue=1-2|pages=121-124|doi=10.1016/0166-4328(96)00081-2|issn=0166-4328|eissn=1872-7549|oclc=06183451}}</ref> Ayahuasca brews have been used traditionally in South America since at least around the year 1500.<ref>{{cite web|url=http://www.erowid.org/chemicals/dmt/dmt_basics.shtml|publisher=Erowid|title=Erowid DMT Vault: Basics|access-date=January 7, 2020|date=August 22, 2000}}</ref>
-* Insufflation (snorting): DMT absorbed through the nose may drip down your throat and be swallowed. If swallowed, it will be broken down in your stomach and have no effect.
 ===Variety of DMT methods and routes of administration===
@@ Line 65: / Line 61: @@
 **Intravenous injection of DMT crystals (from 4 to 20 mg; unknown duration, assumed higher than that of intravenous DMT without prior harmalas ingestion)
 **Intramuscular injection of DMT crystals (up to 80 mg; unknown duration, assumed higher than that of intramuscular DMT without prior harmalas ingestion)
+====Limitations====
+* Oral: Oral [[DMT]] is inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, DMT is frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]]. When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]].<ref>{{cite journal|last=Strassman|first=Rick J.|title=Human psychopharmacology of N,N-dimethyltryptamine|year=1995|journal=Behavioural Brain Research|volume=73|issue=1-2|pages=121-124|doi=10.1016/0166-4328(96)00081-2|issn=0166-4328|eissn=1872-7549|oclc=06183451}}</ref> Ayahuasca brews have been used traditionally in South America since at least around the year 1500.<ref>{{cite web|url=http://www.erowid.org/chemicals/dmt/dmt_basics.shtml|publisher=Erowid|title=Erowid DMT Vault: Basics|access-date=January 7, 2020|date=August 22, 2000}}</ref>
+* Insufflation (snorting): DMT absorbed through the nose may drip down your throat and be swallowed. If swallowed, it will be broken down in your stomach and have no effect.
 ==Subjective effects==