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DMT: Difference between revisions
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When [[vaporized]] or [[smoked]], DMT produces short-lived effects with a very rapid onset that is sometimes described as an "inconceivably high-speed rollercoaster ride." | When [[vaporized]] or [[smoked]], DMT produces short-lived effects with a very rapid onset that is sometimes described as an "inconceivably high-speed rollercoaster ride." | ||
When ingested in combination with a [[MAOI]] or [[RIMA]] agent, it becomes active [[oral|orally]] and significantly longer lasting, immersive, and interactive in nature: this combination is known as [[ayahuasca]]. | When ingested in combination with a [[MAOI]] or [[RIMA]] agent, it becomes active [[oral|orally]] and significantly longer lasting, immersive, and interactive in nature: this combination is known as [[pharmahuasca]]. See also [[ayahuasca]]. | ||
Unlike most highly prohibited substances, DMT has not been proven to be addictive or physiologically toxic.<ref name="Nichols2016"></ref><ref>{{cite journal|last1=Lüscher|first1=Christian|last2=Ungless|first2=Mark A.|title=The Mechanistic Classification of Addictive Drugs|year=2006|journal=PLOS Medicine|volume=3|issue=11|doi=10.1371/journal.pmed.0030437|pmid=17105338|issn=1549-1277}}</ref> | Unlike most highly prohibited substances, DMT has not been proven to be addictive or physiologically toxic.<ref name="Nichols2016"></ref><ref>{{cite journal|last1=Lüscher|first1=Christian|last2=Ungless|first2=Mark A.|title=The Mechanistic Classification of Addictive Drugs|year=2006|journal=PLOS Medicine|volume=3|issue=11|doi=10.1371/journal.pmed.0030437|pmid=17105338|issn=1549-1277}}</ref> | ||
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===Route of administration=== | ===Route of administration=== | ||
* Oral: DMT is inactive | * Oral: Oral [[DMT]] is inactive because stomach enzymes called MAO enzymes break it down. To experience effects orally, DMT is frequently combined with [[MAO inhibitor]]s (MAOIs), which prevent this breakdown. This combination is known as [[pharmahuasca]]. When the MAOIs and DMT are derived from plant extracts, it is referred to as [[ayahuasca]]. | ||
* Insufflation (snorting): DMT absorbed through the nose may drip down your throat and be swallowed. If swallowed, it will be broken down in your stomach and have no effect. | * Insufflation (snorting): DMT absorbed through the nose may drip down your throat and be swallowed. If swallowed, it will be broken down in your stomach and have no effect. | ||
<ref>{{cite journal|last=Strassman|first=Rick J.|title=Human psychopharmacology of N,N-dimethyltryptamine|year=1995|journal=Behavioural Brain Research|volume=73|issue=1-2|pages=121-124|doi=10.1016/0166-4328(96)00081-2|issn=0166-4328|eissn=1872-7549|oclc= 06183451}}</ref> | |||
Ayahuasca brews have been used traditionally in South America since at least around the year 1500.<ref>{{cite web|url=http://www.erowid.org/chemicals/dmt/dmt_basics.shtml|publisher=Erowid|title=Erowid DMT Vault: Basics|access-date=January 7, 2020|date=August 22, 2000}}</ref> | |||
===Variety of DMT methods and routes of administration=== | ===Variety of DMT methods and routes of administration=== | ||