Talk:Brorphine: Difference between revisions

>LockPicker
Created
>LockPicker
expanded
Line 11: Line 11:
==History and culture==
==History and culture==
{{historyStub}}
{{historyStub}}
Brorphine was first reported to the UNODC Early Warning Advisory on NPS in 2019. After the temporarily scheduling of isotonitazene in June 2020 by the U.S. Drug Enforcement Administration, detections of brorphine in the U.S. began to increase, appearing as similar gray drug powders and an apparent
Brorphine was first described in the scientific literature as a μ-opioid receptor agonist in 2018.<ref name="DEA2020"/> It was first reported to the UNODC Early Warning Advisory on NPS in 2019.<ref name="UNODC2020"/> After the temporarily scheduling of isotonitazene in June 2020 by the U.S. Drug Enforcement Administration, detections of brorphine in the U.S. began to increase, appearing as similar gray drug powders and an apparent
replacement for isotonitazene.<ref name="CFSRE2020">{{cite web|title=The Rise of Brorphine — A Potent New Synthetic Opioid Identified in the Midwestern United States|date=July 2020|first1=A. J.|last1=Krotulski|first2=D. M.|last2=Papsun|first3=C.|last3=Noble|first4=S. L.|last4=Kacinko|first5=L.|last5=Nelson|first6=B. K.|last6=Logan|publisher=Center for Forensic Science Research and Education (CFSRE)|url=https://www.npsdiscovery.org/wp-content/uploads/2020/07/Public-Alert_Brorphine_NPS-Discovery_072720.pdf}}</ref>
replacement for isotonitazene.<ref name="CFSRE2020">{{cite web|title=The Rise of Brorphine — A Potent New Synthetic Opioid Identified in the Midwestern United States|date=July 2020|first1=A. J.|last1=Krotulski|first2=D. M.|last2=Papsun|first3=C.|last3=Noble|first4=S. L.|last4=Kacinko|first5=L.|last5=Nelson|first6=B. K.|last6=Logan|publisher=Center for Forensic Science Research and Education (CFSRE)|url=https://www.npsdiscovery.org/wp-content/uploads/2020/07/Public-Alert_Brorphine_NPS-Discovery_072720.pdf}}</ref>


==Chemistry==
==Chemistry==
{{chemistry}}
{{chemistry}}
Brorphine is an atypical opioid of the piperidine and benzimidazolone class which has some structural similarities with fentanyl.<ref name="UNODC2020"/><ref name="CFSRE2020"/>
Brorphine is an atypical opioid of the piperidine and benzimidazolone class which has some structural similarities with fentanyl.<ref name="UNODC2020"/><ref name="CFSRE2020"/> It is comprised of three main units: A 4-bromophenethyl group, a piperidine ring, and a 1,3-dihydro-2H-benzoimidzole-2-one group. Brorphine is being trafficked as its hydrochloride salt which would be water-soluble.<ref name="DEA2020">{{cite web|date=August 2020|title=Brorphine|url=https://www.deadiversion.usdoj.gov/drug_chem_info/brorphine.pdf|publisher=Drug Enforcement Administration (DEA)}}</ref>


==Pharmacology==
==Pharmacology==
Line 71: Line 71:
Brorphine has a [[Toxicity::high toxicity relative to its dose due to its extreme potency]]. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[benzodiazepines]]]].
Brorphine has a [[Toxicity::high toxicity relative to its dose due to its extreme potency]]. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[benzodiazepines]]]].


Recent detections in drug related deaths leads us to believe this new synthetic opioid has the potential to cause widespread harm.<ref name="CFSRE2020"/>
Recent detections in drug related deaths leads to the conclusion that brorphine has the potential to cause widespread harm.<ref name="CFSRE2020"/> There are no published studies on safety for human use as of August 2020.<ref name="DEA2020"/>




Line 91: Line 91:
{{LegalStub}}
{{LegalStub}}
Brorphine is not under international control.<ref name="UNODC2020"/>
Brorphine is not under international control.<ref name="UNODC2020"/>
*'''United States''': Brorphine is not a controlled under the Controlle Substances Act as of August 2020.<ref name="DEA2020"/>


==See also==
==See also==
Return to "Brorphine" page.