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Agonist: Difference between revisions
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An '''agonist''' is a chemical that binds to the [[receptor]] of a cell and activates the receptor to cause a physiological response. An agonist initiates the same reaction typically produced by the binding of an endogenous ligand (such as a hormone or neurotransmitter) with a receptor.<ref>Agonist definition (Merriam-Webster) http://www.merriam-webster.com/dictionary/agonist</ref> A drug’s ability to affect a given receptor is dependent on the drug’s affinity and intrinsic efficacy towards that receptor. The affinity of a drug describes the strength of attraction between it and a given receptor, and consequently its ability to bind to that receptor. A drug with a high affinity for a receptor has a high likelihood of binding to it, while a drug with a low affinity has a lesser degree of attraction towards a receptor. | An '''agonist''' is a chemical that binds to the [[receptor]] of a cell and activates the receptor to cause a physiological response. An agonist initiates the same reaction typically produced by the binding of an endogenous ligand (such as a hormone or neurotransmitter) with a receptor.<ref>Agonist definition (Merriam-Webster) http://www.merriam-webster.com/dictionary/agonist</ref> A drug’s ability to affect a given receptor is dependent on the drug’s affinity and intrinsic efficacy towards that receptor. The affinity of a drug describes the strength of attraction between it and a given receptor, and consequently its ability to bind to that receptor. A drug with a high affinity for a receptor has a high likelihood of binding to it, while a drug with a low affinity has a lesser degree of attraction towards a receptor. | ||
This contrasts the efficacy of a drug, which describes a drug's capacity to produce a response when bound to a receptor. A drug with high efficacy will produce a proportionally stronger effect than a drug of lower efficacy occupying the same number of receptors. The maximum efficacy of a drug reflects the greatest attainable response to a particular drug on a receptor set regardless of dose. A drug with a high efficacy may need to occupy | This contrasts the efficacy of a drug, which describes a drug's capacity to produce a response when bound to a receptor. A drug with high efficacy will produce a proportionally stronger effect than a drug of lower efficacy occupying the same number of receptors. The maximum efficacy of a drug reflects the greatest attainable response to a particular drug on a receptor set regardless of dose. A drug with a high efficacy may need to occupy fewer receptors to produce maximum effects, meaning it will not produce stronger effects beyond a certain dosage. | ||
In contrast to an agonist, an [[antagonist]] is a chemical that binds to the receptor of a cell without causing a physiological response. Receptor antagonists work by blocking or diminishing the effects produced by endogenous or drug-induced agonism of a receptor. | In contrast to an agonist, an [[antagonist]] is a chemical that binds to the receptor of a cell without causing a physiological response. Receptor antagonists work by blocking or diminishing the effects produced by endogenous or drug-induced agonism of a receptor. | ||
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===Agonists=== | ===Agonists=== | ||
There are several types of agonist: | There are several types of agonist: | ||
*A '''superagonist''' is an agonist that produces a greater effect from the receptor than the endogenous agonist, and therefore has an efficacy of over 100%. | *A '''superagonist''' is an agonist that produces a greater effect from the receptor than the endogenous agonist, and therefore has an efficacy of over 100%. | ||
*A '''full agonist''' binds and activates a receptor with an efficacy equal to the endogenous agonist. For example, [[heroin]] mimics the action of endorphins on μ-opioid receptors in the nervous system. | *A '''full agonist''' binds and activates a receptor with an efficacy equal to the endogenous agonist. For example, [[heroin]] mimics the action of endorphins on μ-opioid receptors in the nervous system. | ||
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==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Scientific information]] | *[[Scientific information]] | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/Agonist Agonist (Wikipedia)] | *[https://en.wikipedia.org/wiki/Agonist Agonist (Wikipedia)] | ||
==References== | ==References== | ||
<references/> | <references /> | ||
[[Category:Neuroscience]] | [[Category:Neuroscience]] | ||