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Talk:Glaucine: Difference between revisions
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Glaucine is an aporphine, meaning 'not [[morphine]].' It is named this because despite similar structure to morphine, it is in fact not morphine. Aporphine is the parent compound of glaucine, where glaucine has methoxy groups substituted at the 1, 2, 9, and 10 positions. Glaucine has one stereocenter, meaning it has two stereoisomers. Both stereoisomers are found in nature, albeit in different plants.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174169</ref>{{chemistry}} | Glaucine is an aporphine, meaning 'not [[morphine]].' It is named this because despite similar structure to morphine, it is in fact not morphine. Aporphine is the parent compound of glaucine, where glaucine has methoxy groups substituted at the 1, 2, 9, and 10 positions. Glaucine has one stereocenter, meaning it has two stereoisomers. Both stereoisomers are found in nature, albeit in different plants.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174169</ref>{{chemistry}} | ||
==Pharmacology== | ==Pharmacology== | ||
{{pharmacology}} | Glaucine is a sedative-psychedelic. The psychedelic effects perceived from glaucine are in fact from interaction of 5-HT<sub>2A</sub> receptors, but both stereoisomers of glaucine interact with the receptor differently. (S)-glaucine is an agonist of the receptor, the same action performed by psychedelics like [[LSD]] and [[mescaline]], but (R)-glaucine is a positive allosteric modulator, meaning it boosts the signaling and activity at the receptor.{{pharmacology}} | ||
==Subjective effects== | ==Subjective effects== | ||