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Talk:Hydroxyzine: Difference between revisions
>Sugar Cleaned up Intro, History and Culture, Chemistry, and Pharmacology sections. Removed some incorrect/inappropriate claims, mainly the claim that combination with other depressants can cause respiratory depression. |
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Tolerance to the CNS effects of hydroxyzine develops rapidly, often in as few as 3-7 days.<ref> Levander S, Ståhle-Bäckdahl M, Hägermark O (1 September 1991). "Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine". European Journal of Clinical Pharmacology. 41 (5): 435–439. doi:10.1007/BF00626365. PMID 1684750. S2CID 25249362.</ref> Tolerance to its sedative effects builds faster than tolerance to its anxiolytic effects. Such, it is indicated for use in short-term or as-needed [[insomnia]] treatment. | Tolerance to the CNS effects of hydroxyzine develops rapidly, often in as few as 3-7 days.<ref> Levander S, Ståhle-Bäckdahl M, Hägermark O (1 September 1991). "Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine". European Journal of Clinical Pharmacology. 41 (5): 435–439. doi:10.1007/BF00626365. PMID 1684750. S2CID 25249362.</ref> Tolerance to its sedative effects builds faster than tolerance to its anxiolytic effects. Such, it is indicated for use in short-term or as-needed [[insomnia]] treatment. | ||
==History and | ==History and Culture== | ||
{{historyStub}} | {{historyStub}} | ||
Hydroxyzine was first synthesized by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year.<ref>"Hydroxyzine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 21 Nov 2018.</ref><ref>Shorter E (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 9780195368741.</ref> Originally mostly given for nausea and allergies, it later began to be used in medicine for its anxiolytic properties. It is sometimes given as a substitute to benzodiazepines in surgeries to decrease anxiety and act as an anesthetic. In the United Kingdom 28 doses cost less than a pound.<ref>British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0857112989.</ref> In the United States the wholesale cost in 2018 was about 0.05 USD per dose.<ref>"NADAC as of 2018-11-21". Centers for Medicare and Medicaid Services. Retrieved 21 Nov 2018.</ref> In the United States about 8 million prescriptions were written for hydroxyzine in 2016.<ref>British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0857112989.</ref> | Hydroxyzine was first synthesized by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year.<ref>"Hydroxyzine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 21 Nov 2018.</ref><ref>Shorter E (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 9780195368741.</ref> Originally mostly given for nausea and allergies, it later began to be used in medicine for its anxiolytic properties. It is sometimes given as a substitute to benzodiazepines in surgeries to decrease anxiety and act as an anesthetic. In the United Kingdom 28 doses cost less than a pound.<ref>British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0857112989.</ref> In the United States the wholesale cost in 2018 was about 0.05 USD per dose.<ref>"NADAC as of 2018-11-21". Centers for Medicare and Medicaid Services. Retrieved 21 Nov 2018.</ref> In the United States about 8 million prescriptions were written for hydroxyzine in 2016.<ref>British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0857112989.</ref> | ||