4-AcO-DET: Difference between revisions

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'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine''', '''ethacetin''') is ~~an obscure synthetic~~ [[psychoactive class::psychedelic]] [[chemical class::tryptamine]]. There is very little ~~information~~ on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>{{cite journal|title=Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography–mass spectrometry|pmid=19084633|doi=10.1016/j.talanta.2008.07.062|last1=Takahashi|first1=M.|last2=Nagashima|first2=M.|last3=Suzuki|first3=J.|last4=Yasuda|first4=I|last5=Yoshida|first5=T.|volume=77|issue=4|date=February 15, 2009|pages=1245-1272|issn=0039-9140|eissn=1873-3573|oclc=01767116}}</ref> ~~Today it is either used recreationally as a [[designer drug]] or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors.~~ It remains relatively rare and has very little documented history of human usage.

'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine''', '''ethacetin''') is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class. It is chemically related to [[psilocin]] and part of a series of substituted tryptamines that includes 4-AcO-MET and 4-AcO-DMT.

Today it is either used recreationally as a [[designer drug]] or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors.

There is very little data on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>{{cite journal|title=Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography–mass spectrometry|pmid=19084633|doi=10.1016/j.talanta.2008.07.062|last1=Takahashi|first1=M.|last2=Nagashima|first2=M.|last3=Suzuki|first3=J.|last4=Yasuda|first4=I|last5=Yoshida|first5=T.|volume=77|issue=4|date=February 15, 2009|pages=1245-1272|issn=0039-9140|eissn=1873-3573|oclc=01767116}}</ref> It remains relatively rare and has very little documented history of human usage. It is highly advised to use [[harm reduction practices]] if using this substance.

4-AcO-DET is the acetylated form of [[4-HO-DET]] (also known as ethocin) and is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]]. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}}

==Chemistry==

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone ([[DET]]).

4-AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] (psilocin). 4-AcO-DET is the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/24801867|title=Compound Summary - 3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate|website=PubChem|access-date=July 18, 2020}}</ref>

4-AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] (psilocin). 4-AcO-DET is the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/24801867|title=Compound Summary - 3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate|website=PubChem|access-date=July 18, 2020}}</ref> It is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]].

4-substituted acetylated tryptamines such as [[4-AcO-DET]], 4-AcO-MET, and 4-AcO-DMT are hypothesized to principally act as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}}

==Pharmacology==

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 {{SubstanceBox/4-AcO-DET}}
-'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine''', '''ethacetin''') is an obscure synthetic [[psychoactive class::psychedelic]] [[chemical class::tryptamine]]. There is very little information on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>{{cite journal|title=Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography–mass spectrometry|pmid=19084633|doi=10.1016/j.talanta.2008.07.062|last1=Takahashi|first1=M.|last2=Nagashima|first2=M.|last3=Suzuki|first3=J.|last4=Yasuda|first4=I|last5=Yoshida|first5=T.|volume=77|issue=4|date=February 15, 2009|pages=1245-1272|issn=0039-9140|eissn=1873-3573|oclc=01767116}}</ref> Today it is either used recreationally as a [[designer drug]] or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. It remains relatively rare and has very little documented history of human usage.
+'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine''', '''ethacetin''') is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class. It is chemically related to [[psilocin]] and part of a series of substituted tryptamines that includes 4-AcO-MET and 4-AcO-DMT.
+Today it is either used recreationally as a [[designer drug]] or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors.
+There is very little data on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>{{cite journal|title=Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography–mass spectrometry|pmid=19084633|doi=10.1016/j.talanta.2008.07.062|last1=Takahashi|first1=M.|last2=Nagashima|first2=M.|last3=Suzuki|first3=J.|last4=Yasuda|first4=I|last5=Yoshida|first5=T.|volume=77|issue=4|date=February 15, 2009|pages=1245-1272|issn=0039-9140|eissn=1873-3573|oclc=01767116}}</ref> It remains relatively rare and has very little documented history of human usage. It is highly advised to use [[harm reduction practices]] if using this substance.
--AcO-DET is the acetylated form of [[4-HO-DET]] (also known as ethocin) and is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]]. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}}
 ==Chemistry==
 -AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R<sub>4</sub> of its indole heterocycle with an acetoxy (AcO) functional group CH<sub>3</sub>COO−. It also contains isopropyl and methyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DET]]).
--AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] (psilocin). 4-AcO-DET is the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/24801867|title=Compound Summary - 3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate|website=PubChem|access-date=July 18, 2020}}</ref>
+-AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] (psilocin). 4-AcO-DET is the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/24801867|title=Compound Summary - 3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate|website=PubChem|access-date=July 18, 2020}}</ref> It is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]].
+-substituted acetylated tryptamines such as [[4-AcO-DET]], 4-AcO-MET, and 4-AcO-DMT are hypothesized to principally act as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}}
 ==Pharmacology==