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Talk:5-MeO-aMT: Difference between revisions
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==Chemistry== | ==Chemistry== | ||
5-MeO-aMT, or 5-methoxy-α-methyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 5-MeO-aMT is substituted at the alpha carbon R<sub>α</sub> of its tryptamine backbone with a methyl group. | 5-MeO-aMT, or 5-methoxy-α-methyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. Like [[aMT]], 5-MeO-aMT is substituted at the alpha carbon R<sub>α</sub> of its tryptamine backbone with a methyl group, but differs from aMT by a methoxy group added to the R<sub>5</sub> position. | ||
A comparison of the R- and S-isomers found that the S-isomer is "clearly three or four times more potent" than the R-isomer. The S-isomer is the d- or dextrorotary one and has been noted to possess the absolute configuration of the active member of the isomer pairs of [[amphetamine]], [[methamphetamine]], and [[MDMA]].<ref name="tihkalweb" /> | A comparison of the R- and S-isomers found that the S-isomer is "clearly three or four times more potent" than the R-isomer. The S-isomer is the d- or dextrorotary one and has been noted to possess the absolute configuration of the active member of the isomer pairs of [[amphetamine]], [[methamphetamine]], and [[MDMA]].<ref name="tihkalweb" /> | ||
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==Pharmacology== | ==Pharmacology== | ||
{{Further|Serotonergic psychedelic}} | {{Further|Serotonergic psychedelic}} | ||
5-MeO-aMT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. | 5-MeO-aMT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive. | ||
5-MeO-AMT also inhibits [[monoamines]] ([[dopamine]], [[serotonin]] and [[norepinephrine]]) reuptake and stimulates their release.<ref>The Effects of Non-Medically Used Psychoactive Drugs on Monoamine Neurotransmission in Rat Brain | https://pubmed.ncbi.nlm.nih.gov/17223101</ref> | |||
==Subjective effects== | ==Subjective effects== | ||
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*[https://en.wikipedia.org/wiki/5-MeO-aMT 5-MeO-aMT (Wikipedia)] | *[https://en.wikipedia.org/wiki/5-MeO-aMT 5-MeO-aMT (Wikipedia)] | ||
*[https://www.erowid.org/chemicals/5meo_amt/ 5-MeO-aMT (Erowid Vault)] | *[https://www.erowid.org/chemicals/5meo_amt/ 5-MeO-aMT (Erowid Vault)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?id=5005 5-MeO-aMT (Isomer Design)] | *[https://isomerdesign.com/PiHKAL/explore.php?id=5005 5-MeO-aMT (TiHKAL / Isomer Design)] | ||
===Discussion=== | |||
*[https://www.bluelight.org/xf/threads/61754 The Big & Dandy 5-MeO-AMT Thread (Bluelight)] | |||
==References== | ==References== | ||
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[[Category:Psychedelic]] | [[Category:Psychedelic]] | ||
[[Category:Entactogen]] | [[Category:Entactogen]] | ||
[[Category:Stimulant]] | |||
[[Category:Approval]] | [[Category:Approval]] | ||
[[Category:Proofread]] | [[Category:Proofread]] | ||