Research chemicals: Difference between revisions

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Combining research chemicals presents a risk due to the lack of research and understanding of their pharmacological and toxicological effects. For example, if a research chemical has [[MAOI]] effects (like 2C-T-7), this could make it dangerous to combine it with other [[MAOI]]s, [[stimulant]]s and certain substances which release [[serotonin]] or [[dopamine]]. It is recommended to avoid blends or branded products if the active psychoactive compounds are not listed on the labeling.<ref name="tripsit">Research Chemicals (Tripsit) | https://wiki.tripsit.me/wiki/Research_Chemicals</ref>

Several fatal overdoses have occurred due to [[Bromo-DragonFLY]] accidentally being mislabelled by online vendors as both [[2C-B-FLY]]<ref name="2cbfly">Information on Reported Deaths Related to 2C-B-FLY Misidentified Substance is Most Likely Bromo-dragonfly by the Erowid Crew v1.6 - Nov 9, 2009 | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref> and [[2C-E]].<ref name="2ce">Bromo-Dragonfly Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/bromo_dragonfly/bromo_dragonfly_death.shtml</ref><ref name="2ce2">Second Victim Dies After Taking Designer Drug In Konawa | http://www.newson6.com/story/14641463/second-victim-dies-after-taking-designer-drug-in-konawa</ref> The former is active in the 200-800μg range and is significantly more potent than 2C-E.

Several fatal overdoses have occurred due to [[Bromo-DragonFLY]] accidentally being mislabelled by online vendors as both [[2C-B-FLY]]<ref name="2cbfly">Information on Reported Deaths Related to 2C-B-FLY Misidentified Substance is Most Likely Bromo-dragonfly by the Erowid Crew v1.6 - Nov 9, 2009 | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref> and [[2C-E]].<ref name="2ce">Bromo-Dragonfly Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/bromo_dragonfly/bromo_dragonfly_death.shtml</ref><ref name="2ce2">Second Victim Dies After Taking Designer Drug In Konawa | http://www.newson6.com/story/14641463/second-victim-dies-after-taking-designer-drug-in-konawa</ref> The former is active in the 200-800μg range and is significantly more potent than 2C-E. These situations can be avoided by dosing a minuscule amount of a drug (roughly 0.5 milligrams) and waiting for several hours. This is known as an "allergy test". It is recommended to do this for all new batches of substances.

Situations like this can be avoided by dosing a minuscule amount of a drug (roughly 0.5 milligrams) and waiting for several hours. This is known as an "allergy test". It is recommended to do this for all new batches of substances.

Anecdotal evidence from users suggests that there do not seem to be any negative health effects attributed to simply trying research chemicals at low to moderate doses by themselves and using them sparingly. However, nothing can be guaranteed. For example, in one extreme case, the research chemical [[MPPP]] was found in some cases to contain an impurity called [[MPTP]], which caused brain damage that resulted in a syndrome identical to Parkinson's disease from only a single dose.<ref name="faq"></ref>

Anecdotal evidence from ~~people who have tried research chemicals within the community suggest~~ that there do not seem to be any negative health effects attributed to simply trying research chemicals at low to moderate doses by themselves and using them sparingly. However, nothing can be guaranteed. For example, in one extreme case, the research chemical [[MPPP]] was found in some cases to contain an impurity called [[MPTP]], which caused brain damage that resulted in a syndrome identical to Parkinson's disease from only a single dose.<ref name="faq"></ref>

===Pharmacological deaths===

Pharmacological deaths are fatalities caused by the direct action of the chemical in the body and do not include deaths as a result of inebriated behavior. The content below is an incomplete list.

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 Combining research chemicals presents a risk due to the lack of research and understanding of their pharmacological and toxicological effects. For example, if a research chemical has [[MAOI]] effects (like 2C-T-7), this could make it dangerous to combine it with other [[MAOI]]s, [[stimulant]]s and certain substances which release [[serotonin]] or [[dopamine]]. It is recommended to avoid blends or branded products if the active psychoactive compounds are not listed on the labeling.<ref name="tripsit">Research Chemicals (Tripsit) | https://wiki.tripsit.me/wiki/Research_Chemicals</ref>
-Several fatal overdoses have occurred due to [[Bromo-DragonFLY]] accidentally being mislabelled by online vendors as both [[2C-B-FLY]]<ref name="2cbfly">Information on Reported Deaths Related to 2C-B-FLY Misidentified Substance is Most Likely Bromo-dragonfly by the Erowid Crew v1.6 - Nov 9, 2009 | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref> and [[2C-E]].<ref name="2ce">Bromo-Dragonfly Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/bromo_dragonfly/bromo_dragonfly_death.shtml</ref><ref name="2ce2">Second Victim Dies After Taking Designer Drug In Konawa | http://www.newson6.com/story/14641463/second-victim-dies-after-taking-designer-drug-in-konawa</ref> The former is active in the 200-800μg range and is significantly more potent than 2C-E.
+Several fatal overdoses have occurred due to [[Bromo-DragonFLY]] accidentally being mislabelled by online vendors as both [[2C-B-FLY]]<ref name="2cbfly">Information on Reported Deaths Related to 2C-B-FLY Misidentified Substance is Most Likely Bromo-dragonfly by the Erowid Crew v1.6 - Nov 9, 2009 | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref> and [[2C-E]].<ref name="2ce">Bromo-Dragonfly Fatalities / Deaths by Erowid | https://www.erowid.org/chemicals/bromo_dragonfly/bromo_dragonfly_death.shtml</ref><ref name="2ce2">Second Victim Dies After Taking Designer Drug In Konawa | http://www.newson6.com/story/14641463/second-victim-dies-after-taking-designer-drug-in-konawa</ref> The former is active in the 200-800μg range and is significantly more potent than 2C-E. These situations can be avoided by dosing a minuscule amount of a drug (roughly 0.5 milligrams) and waiting for several hours. This is known as an "allergy test". It is recommended to do this for all new batches of substances.
-Situations like this can be avoided by dosing a minuscule amount of a drug (roughly 0.5 milligrams) and waiting for several hours. This is known as an "allergy test". It is recommended to do this for all new batches of substances.
+Anecdotal evidence from users suggests that there do not seem to be any negative health effects attributed to simply trying research chemicals at low to moderate doses by themselves and using them sparingly. However, nothing can be guaranteed. For example, in one extreme case, the research chemical [[MPPP]] was found in some cases to contain an impurity called [[MPTP]], which caused brain damage that resulted in a syndrome identical to Parkinson's disease from only a single dose.<ref name="faq"></ref>
-Anecdotal evidence from people who have tried research chemicals within the community suggest that there do not seem to be any negative health effects attributed to simply trying research chemicals at low to moderate doses by themselves and using them sparingly. However, nothing can be guaranteed. For example, in one extreme case, the research chemical [[MPPP]] was found in some cases to contain an impurity called [[MPTP]], which caused brain damage that resulted in a syndrome identical to Parkinson's disease from only a single dose.<ref name="faq"></ref>
 ===Pharmacological deaths===
 Pharmacological deaths are fatalities caused by the direct action of the chemical in the body and do not include deaths as a result of inebriated behavior. The content below is an incomplete list.