This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Dangerous combinations: Difference between revisions
>Unity m Grammatics |
>Unity |
||
| Line 5: | Line 5: | ||
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. | Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. | ||
Drug related deaths most commonly occur when combining [[ | Drug related deaths most commonly occur when combining [[depressant]]s. Depressants affect parts of the brain that are responsible for respiration, and an overdose or combination of these drugs can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to suffocate from their own vomit. Lying in the [[recovery position]] can prevent one from inhaling their own vomit. | ||
[[File:Standard-recovery-position.jpg|250px|thumbnail|Lying in the [[recovery position]] can prevent one from inhaling their own vomit.]] | [[File:Standard-recovery-position.jpg|250px|thumbnail|Lying in the [[recovery position]] can prevent one from inhaling their own vomit.]] | ||
Another possibly fatal combination of drugs are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said drug. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI). | Another possibly fatal combination of drugs are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said drug. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI). | ||
== | == Depressants == | ||
===[[Benzodiazepines]]/[[Thienzodiazepines]] === | ===[[Benzodiazepines]]/[[Thienzodiazepines]] === | ||
*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[Ketamine]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it. | *'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2-methyl-2-butanol]], [[alcohol]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[Ketamine]], [[opioids]]'') - This combination can result in dangerous or even fatal levels of [[respiratory depression]]. These substances potentiate the [[muscle relaxation]], [[sedation]] and [[amnesia]] caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If [[nausea]] or vomiting occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it. | ||
| Line 26: | Line 26: | ||
*'''[[Stimulants]]''' - It is dangerous to combine alcohol, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. This combination can also potentially result in severe dehydration if hydration is not monitored. It also interacts with [[cocaine]] in vivo to produce [[Cocaine#Interactions|cocaethylene]], another psychoactive substance.<ref>Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases | http://dmd.aspetjournals.org/content/31/1/16</ref> | *'''[[Stimulants]]''' - It is dangerous to combine alcohol, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. This combination can also potentially result in severe dehydration if hydration is not monitored. It also interacts with [[cocaine]] in vivo to produce [[Cocaine#Interactions|cocaethylene]], another psychoactive substance.<ref>Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases | http://dmd.aspetjournals.org/content/31/1/16</ref> | ||
*'''[[MAOI]]'''s - This combination can result in dangerous reactions through the way in which tyramine, a chemical commonly found in alcoholic beverages, causes [[increased blood pressure]]. | *'''[[MAOI]]'''s - This combination can result in dangerous reactions through the way in which tyramine, a chemical commonly found in alcoholic beverages, causes [[increased blood pressure]]. | ||
== Serotonergic drugs == | |||
===[[MAOI|Monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI) === | ===[[MAOI|Monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI) === | ||
| Line 39: | Line 41: | ||
* [[Research chemicals]] | * [[Research chemicals]] | ||
* [http://wiki.tripsit.me/wiki/Drug_combinations Drug combination guide and chart (TripSit]) | * [http://wiki.tripsit.me/wiki/Drug_combinations Drug combination guide and chart (TripSit]) | ||
{{Template:Responsible use2}}[[Category:Responsible drug use]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||