Talk:Oxymorphazone: Difference between revisions

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===Experience reports===

There are currently {{#ask:[[Category:~~SUBSTANCE~~]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].

There are currently {{#ask:[[Category:Oxymorphazone]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].

{{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}}

~~Additional experience reports can be found here:~~

* [https://www.erowid.org/experiences/subs/exp_SUBSTANCE.shtml Erowid Experience Vaults: SUBSTANCE]

==Toxicity and harm potential==

Oxymorphazone has a [[Toxicity::low toxicity]] relative to dose. As with all opioids, long-term effects can vary but can include diminished libido, apathy, and memory loss. It is also [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[benzodiazepines]]]].

Oxymorphazone has a [[Toxicity::low toxicity]] relative to dose. It is estimated to be half too 100% as potent as oxymorphpne, suggesting that 10mg Oxymorphazone is equivalent to approximately 30mg morphine <ref>[Pergolizzi Jr., J., & Raffa, R. (2009). Oxymorphone and Opioid Rotation. Pain Medicine, 10(Suppl 1), S39-S48.]</ref>. As with all opioids, long-term effects can vary but can include diminished libido, apathy, and memory loss. It is also [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[benzodiazepines]]]].

Oxymorphazone use is considered '''extremely''' dangerous. This is because if overdose occurs, anatagonism of the [[μ-opioid]] [[receptor]] is not possible. Drugs such as [[naloxone]] are unable to knock oxymorphazone off the MOR, and as such are useless in treating oxymorphazone overdose. There are no MOR hydrazone antagonists (that would knock oxymorphazone off the MOR) on the market. Treatment of oxymorphazone overdose would be supportive care (such as mechanical ventilation) and ensuring the patient does not aspirate on their vomit.

@@ Line 147: / Line 147: @@
 ===Experience reports===
-There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
+There are currently {{#ask:[[Category:Oxymorphazone]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
 {{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}}
-Additional experience reports can be found here:
-* [https://www.erowid.org/experiences/subs/exp_SUBSTANCE.shtml Erowid Experience Vaults: SUBSTANCE] <!-- Check the link to see if it exists -->
 ==Toxicity and harm potential==
 {{toxicity}}
-Oxymorphazone has a [[Toxicity::low toxicity]] relative to dose. As with all opioids, long-term effects can vary but can include diminished libido, apathy, and memory loss. It is also [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[benzodiazepines]]]].
+Oxymorphazone has a [[Toxicity::low toxicity]] relative to dose. It is estimated to be half too 100% as potent as oxymorphpne, suggesting that 10mg Oxymorphazone is equivalent to approximately 30mg morphine <ref>[Pergolizzi Jr., J., & Raffa, R. (2009). Oxymorphone and Opioid Rotation. Pain Medicine, 10(Suppl 1), S39-S48.]</ref>. As with all opioids, long-term effects can vary but can include diminished libido, apathy, and memory loss. It is also [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[benzodiazepines]]]].
 Oxymorphazone use is considered '''extremely''' dangerous. This is because if overdose occurs, anatagonism of the [[μ-opioid]] [[receptor]] is not possible. Drugs such as [[naloxone]] are unable to knock oxymorphazone off the MOR, and as such are useless in treating oxymorphazone overdose. There are no MOR hydrazone antagonists (that would knock oxymorphazone off the MOR) on the market. Treatment of oxymorphazone overdose would be supportive care (such as mechanical ventilation) and ensuring the patient does not aspirate on their vomit.