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Efavirenz: Difference between revisions
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{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
{{effects/base | {{effects/base | ||
|{{effects/physical| | |{{effects/physical| | ||
*'''[[Effect::Physical euphoria]]''' - This effect is generally quite mild. | *'''[[Effect::Physical euphoria]]''' - This effect is generally quite mild. | ||
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*'''[[Effect::Stimulation]]''' ''or'' '''[[Effect::Sedation]]''' | *'''[[Effect::Stimulation]]''' ''or'' '''[[Effect::Sedation]]''' | ||
*'''[[Effect::Appetite suppression]]''' | *'''[[Effect::Appetite suppression]]''' | ||
}} | }} | ||
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{{effects/auditory| | {{effects/auditory| | ||
*'''[[Effect::Auditory enhancement | *'''[[Effect::Auditory enhancement]]''' | ||
*'''[[Effect::Auditory distortion | *'''[[Effect::Auditory distortion]]''' | ||
*'''[[Effect::Auditory hallucinations | *'''[[Effect::Auditory hallucinations]]''' | ||
}} | }} | ||
}} | }} | ||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug. | It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug. | ||
===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== | ||
Efavirenz is [[Addiction potential::not known to be habit-forming]]. While developing a tolerance to efavirenz is extremely rare, abusing efavirenz may cause HIV to become resistant to the drug and increase the viral load in patients with HIV. | Efavirenz is [[Addiction potential::not known to be habit-forming]]. While developing a tolerance to efavirenz is extremely rare, abusing efavirenz may cause HIV to become resistant to the drug and increase the viral load in patients with HIV. | ||
===Dangerous interactions=== | |||
As efavirenz may cause hepatoxicity at high doses or after chronic use, it is not recommended to take this substance concurrently with other substances that may cause hepatoxicity. Efavirenz is an inducer of the CYP2B6 and CYP3A4 enzymes of the cytochrome P450 system, and as a result may change the metabolism of drugs metabolized by them. Consuming garlic may decrease serum levels of efavirenz. | |||
====[[Serotonin syndrome]] risk==== | |||
Efavirenz is a weak serotonin reuptake inhibitor, so it is possible that combining heavy doses of efavirenz and the substances listed below may result in serotonin syndrome. | |||
{{DangerousInteractions/SerotoninSyndrome}} | |||
==Legal | ==Legal status== | ||
{{legalStub}} | {{legalStub}} | ||
Efavirenz is not known to be illegal in any jurisdictions, and is considered a prescription only medication. | Efavirenz is not known to be illegal in any jurisdictions, and is considered a prescription only medication. | ||
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==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Substance]][[Category:Psychoactive substance]][[Category:Hallucinogen]] | [[Category:Substance]] | ||
[[Category:Psychoactive substance]] | |||
[[Category:Hallucinogen]] | |||
[[Category:Psychedelic]] | |||