Talk:Olanzapine: Difference between revisions

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[[File:Olanzapine.svg|250px|thumbnail|right|Structure of olanzapine.]]

[[File:Apotex-manufactured olanzapine 5 mg ODT.jpg|400px|thumbnail|right|A five milligram tablet of olanzapine manufactured by Apotex. This tablet is designed to dissolve in the mouth and be absorbed through the blood vessels inside of the mouth.]]

'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine is known to cause weight gain and help induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref> Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Telenzepine is another agent that shares the thienobenzodiazepine core structure.

'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine is known to cause weight gain and help induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref> Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Telenzepine is another agent that shares the thienobenzodiazepine core structure. Olanzapine as useful as a trip aborter, especially for stimulants.

:(doses:

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|{{effects/physical|

*'''[[Appetite stimulation|Hunger]]''' - This often happens over a course of treatment and not with one use.

*'''[[Sedation]]''' - This effect is more often ~~uncomfortable~~ than relaxing

*'''[[Sedation]]''' - This effect is more often uncomfortably tiring than relaxing.

*'''[[Salivation]]'''

*'''[[Muscle relaxation]]'''

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*'''[[Motor control loss]]'''

*'''[[Headaches]]'''

*'''Extrapyramidal symptoms''' - These are often very rare, but can be life-threatening.

**'''Muscle tension'''

**'''Weak voice'''

**'''Blank expression'''

}}

|{{effects/cognitive|

*'''[[Anxiety suppression]]''' - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and serotonergic action rather than GABA-related activity.

*'''[[~~Emotion~~ suppression]]'''

*'''[[Emotionality suppression]]''' - Olanzapine dulls and suppresses emotions.

*'''[[Focus suppression]] & [[Focus enhancement|enhancement]]'''

*'''[[Focus suppression]] or [[Focus enhancement|enhancement]]''' - This often depends on the mental state of the individual.

*'''[[Decreased libido]]'''

*'''[[Sleepiness]]'''

*'''[[Cognitive euphoria]]'''

*'''[[Cognitive euphoria]]''' - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.

*'''[[Cognitive dysphoria]]''' - This often includes an extreme sense of boredom or depression accompanied by uncomfortable sedation.

}}

@@ Line 2: / Line 2: @@
 [[File:Olanzapine.svg|250px|thumbnail|right|Structure of olanzapine.]]
 [[File:Apotex-manufactured olanzapine 5 mg ODT.jpg|400px|thumbnail|right|A five milligram tablet of olanzapine manufactured by Apotex. This tablet is designed to dissolve in the mouth and be absorbed through the blood vessels inside of the mouth.]]
-'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine is known to cause weight gain and help induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref> Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Telenzepine is another agent that shares the thienobenzodiazepine core structure.
+'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine is known to cause weight gain and help induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref> Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Telenzepine is another agent that shares the thienobenzodiazepine core structure. Olanzapine as useful as a trip aborter, especially for stimulants.
 :(doses:
@@ Line 14: / Line 14: @@
 |{{effects/physical|
 *'''[[Appetite stimulation|Hunger]]''' - This often happens over a course of treatment and not with one use.
-*'''[[Sedation]]''' - This effect is more often uncomfortable than relaxing
+*'''[[Sedation]]''' - This effect is more often uncomfortably tiring than relaxing.
 *'''[[Salivation]]'''
 *'''[[Muscle relaxation]]'''
@@ Line 21: / Line 21: @@
 *'''[[Motor control loss]]'''
 *'''[[Headaches]]'''
+*'''Extrapyramidal symptoms''' - These are often very rare, but can be life-threatening.
+**'''Muscle tension'''
+**'''Weak voice'''
+**'''Blank expression'''
 }}
 |{{effects/cognitive|
 *'''[[Anxiety suppression]]''' - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and serotonergic action rather than GABA-related activity.
-*'''[[Emotion suppression]]'''
+*'''[[Emotionality suppression]]''' - Olanzapine dulls and suppresses emotions.
-*'''[[Focus suppression]] & [[Focus enhancement|enhancement]]'''
+*'''[[Focus suppression]] or [[Focus enhancement|enhancement]]''' - This often depends on the mental state of the individual.
 *'''[[Decreased libido]]'''
 *'''[[Sleepiness]]'''
-*'''[[Cognitive euphoria]]'''
+*'''[[Cognitive euphoria]]''' - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.
+*'''[[Cognitive dysphoria]]''' - This often includes an extreme sense of boredom or depression accompanied by uncomfortable sedation.
 }}
 }}