Talk:Clozapine: Difference between revisions

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'''Clozapine''' ~~(also known as~~ '''Clozaril''' and '''FazaClo''') is an [[antipsychotic|atypical antipsychotic]] substance of the tricyclic dibenzodiazepine chemical class that produces antipsychotic, hypnotic, and dulling effects when administered. It is used for treatment-resistant schizophrenia and is considered to be a "drug of last resort," reserved for when all other agents have failed.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> It is also used for schizoaffective disorder, a similar condition.

'''Clozapine''', sold '''Clozaril''' and '''FazaClo''', is an [[antipsychotic|atypical antipsychotic]] substance of the tricyclic dibenzodiazepine chemical class that produces antipsychotic, hypnotic, and dulling effects when administered. It is used for treatment-resistant schizophrenia and is considered to be a "drug of last resort," reserved for when all other agents have failed.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> It is also used for schizoaffective disorder, a similar condition. FazaClo is an orally disintegrating tablet. <ref>Jazz Pharmaceuticals (2017) FazaClo Highlights of Prescribing Information</ref>

Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or other disorders that can be similar, such as acute delirium, bipolar disorder, and extreme cases of anxiety.{{citation needed}} However, it is only approved for use (on-label) in treatment-resistant schizophrenia. Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the structure of the tricyclic antidepressant imipramine.

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*'''[[Effect::Seizure]]'''

*'''[[Effect::Headaches]]'''

*'''[[Effect::Increased heart rate]]''' - Clozapine's anticholinergic activity increases heart rate.

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 {{SubstanceBox/Clozapine}}
-'''Clozapine''' (also known as '''Clozaril''' and '''FazaClo''') is an [[antipsychotic|atypical antipsychotic]] substance of the tricyclic dibenzodiazepine chemical class that produces antipsychotic, hypnotic, and dulling effects when administered. It is used for treatment-resistant schizophrenia and is considered to be a "drug of last resort," reserved for when all other agents have failed.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> It is also used for schizoaffective disorder, a similar condition.
+'''Clozapine''', sold '''Clozaril''' and '''FazaClo''', is an [[antipsychotic|atypical antipsychotic]] substance of the tricyclic dibenzodiazepine chemical class that produces antipsychotic, hypnotic, and dulling effects when administered. It is used for treatment-resistant schizophrenia and is considered to be a "drug of last resort," reserved for when all other agents have failed.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> It is also used for schizoaffective disorder, a similar condition. FazaClo is an orally disintegrating tablet. <ref>Jazz Pharmaceuticals (2017) FazaClo Highlights of Prescribing Information</ref>
 Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or other disorders that can be similar, such as acute delirium, bipolar disorder, and extreme cases of anxiety.{{citation needed}} However, it is only approved for use (on-label) in treatment-resistant schizophrenia. Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the structure of the tricyclic antidepressant imipramine.
@@ Line 36: / Line 36: @@
 *'''[[Effect::Seizure]]'''
 *'''[[Effect::Headaches]]'''
+*'''[[Effect::Increased heart rate]]''' - Clozapine's anticholinergic activity increases heart rate.
 }}