Talk:Clozapine: Difference between revisions

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'''Clozapine''' (trade names '''Clozaril''' and '''FazaClo''') is an atypical antipsychotic medication that is used to treat treatment-resistant schizophrenia. ~~However~~, it only ~~applies~~ to those ~~that~~ have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics){{citation needed}}. Therefore, it is a drug of last resort (DoLR).

'''Clozapine''' (trade names '''Clozaril''' and '''FazaClo''') is an atypical antipsychotic medication that is used to treat treatment-resistant schizophrenia. As such, it is only approved to treat those who have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics){{citation needed}}. Therefore, it is a drug of last resort (DoLR).

Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or other disorders that can be similar, such as acute delirium, bipolar disorder, and extreme cases of anxiety. However, its only ''approved'' (on-label) use is in treatment-resistant schizophrenia.~~<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref>~~ Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the ~~chemical~~ structure of the tricyclic antidepressant imipramine.

'''Clozapine''' (also known as '''Clozaril''' and '''FazaClo''') is a well-known somewhat novel synthetic [[antipsychotic|atypical antipsychotic]] substance of the tricyclic dibenzodiazepine chemical class that produces antipsychotic, hypnotic, and dulling effects when administered. Medically, it is used for treatment-resistant schizophrenia and is a "drug of last resort," only tried when all other agents fail to treat schizophrenia.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> It is also used for schizoaffective disorder, a similar condition. Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or other disorders that can be similar, such as acute delirium, bipolar disorder, and extreme cases of anxiety.{{citation needed}} However, its only ''approved'' (on-label) use is in treatment-resistant schizophrenia. Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the structure of the tricyclic antidepressant imipramine.

==Chemistry==

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 {{SubstanceBox/Clozapine}}
-'''Clozapine''' (trade names '''Clozaril''' and '''FazaClo''') is an atypical antipsychotic medication that is used to treat treatment-resistant schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics){{citation needed}}. Therefore, it is a drug of last resort (DoLR).
+'''Clozapine''' (trade names '''Clozaril''' and '''FazaClo''') is an atypical antipsychotic medication that is used to treat treatment-resistant schizophrenia. As such, it is only approved to treat those who have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics){{citation needed}}. Therefore, it is a drug of last resort (DoLR).
-Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or other disorders that can be similar, such as acute delirium, bipolar disorder, and extreme cases of anxiety. However, its only ''approved'' (on-label) use is in treatment-resistant schizophrenia.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.
+'''Clozapine''' (also known as '''Clozaril''' and '''FazaClo''') is a well-known somewhat novel synthetic [[antipsychotic|atypical antipsychotic]] substance of the tricyclic dibenzodiazepine chemical class that produces antipsychotic, hypnotic, and dulling effects when administered. Medically, it is used for treatment-resistant schizophrenia and is a "drug of last resort," only tried when all other agents fail to treat schizophrenia.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> It is also used for schizoaffective disorder, a similar condition. Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or other disorders that can be similar, such as acute delirium, bipolar disorder, and extreme cases of anxiety.{{citation needed}} However, its only ''approved'' (on-label) use is in treatment-resistant schizophrenia. Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the structure of the tricyclic antidepressant imipramine.
 ==Chemistry==
 {{chemistry}}