Substance P: Difference between revisions

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[[File:~~Substance_P~~.~~png~~|thumb|right|400px||The molecular structure of Substance P.]]

[[File:Substance P.svg|thumb|right|400px||The molecular structure of Substance P.]]

'''Substance P''' (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator affecting the neurokinin receptors. It has most closely been associated with nociception (pain perception),<ref name="pain">Substance P: Transmitter of nociception (minireview) | https://www.sav.sk/journals/endo/full/er0400e.pdf</ref> but seems to have a wide range of effects including an important role in nausea, emesis (vomiting), the rewarding effects of opiates, and likely in regulating stress responses and anxiety/depression-related behavior.<ref name="mood">The role of substance P in stress and anxiety responses | http://search.proquest.com/docview/68938022</ref> SP is found throughout the body, in the brain, peripheral nerve endings and the spine. The full extent of its involvement in neurotransmission and its possible therapeutic or recreational implications is unclear.

Revision as of 08:58, 28 February 2017 view source >White the picture was too big ← Older edit		Revision as of 05:54, 30 August 2017 view source >BronzeManul m Replaced skeletal structure image with standardised svg image. Newer edit →
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	[[File:~~Substance_P~~.~~png~~\|thumb\|right\|400px\|\|The molecular structure of Substance P.]]		[[File:Substance P.svg\|thumb\|right\|400px\|\|The molecular structure of Substance P.]]

	'''Substance P''' (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator affecting the neurokinin receptors. It has most closely been associated with nociception (pain perception),<ref name="pain">Substance P: Transmitter of nociception (minireview) \| https://www.sav.sk/journals/endo/full/er0400e.pdf</ref> but seems to have a wide range of effects including an important role in nausea, emesis (vomiting), the rewarding effects of opiates, and likely in regulating stress responses and anxiety/depression-related behavior.<ref name="mood">The role of substance P in stress and anxiety responses \| http://search.proquest.com/docview/68938022</ref> SP is found throughout the body, in the brain, peripheral nerve endings and the spine. The full extent of its involvement in neurotransmission and its possible therapeutic or recreational implications is unclear.		'''Substance P''' (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator affecting the neurokinin receptors. It has most closely been associated with nociception (pain perception),<ref name="pain">Substance P: Transmitter of nociception (minireview) \| https://www.sav.sk/journals/endo/full/er0400e.pdf</ref> but seems to have a wide range of effects including an important role in nausea, emesis (vomiting), the rewarding effects of opiates, and likely in regulating stress responses and anxiety/depression-related behavior.<ref name="mood">The role of substance P in stress and anxiety responses \| http://search.proquest.com/docview/68938022</ref> SP is found throughout the body, in the brain, peripheral nerve endings and the spine. The full extent of its involvement in neurotransmission and its possible therapeutic or recreational implications is unclear.