Talk:Clozapine: Difference between revisions

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'''Clozapine''' (trade names '''Clozaril''' and '''FazaClo''') is an atypical antipsychotic medication that is used to treat severe schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics). Therefore, it is a drug of last resort (DoLR).

Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or similar ~~disorders (~~acute delirium, bipolar disorder, extreme cases of anxiety). Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.

Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or other disorders that can be similar, such as acute delirium, bipolar disorder, and extreme cases of anxiety. However, its only ''approved'' (on-label) use is in treatment-resistant schizophrenia.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.

==Chemistry==

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==Pharmacology==

Cloazapine classified as an atypical antipsychotic agent. It binds to several types of central nervous system receptors and displays a unique pharmacological profile. It is a [[serotonin]] antagonist, with strong binding to the 5-HT2A and 5-HT2C receptor subtypes.

Cloazapine is classified as and was the first atypical antipsychotic agent. It binds to several types of central nervous system receptors and displays a unique pharmacological profile. It is a [[serotonin]] antagonist, with strong binding to the 5-HT2A and 5-HT2C receptor subtypes.

It also displays a strong affinity to several [[dopamine|dopaminergic]] receptors, but shows only weak antagonism at the dopamine D2 receptor, which is commonly thought to modulate neuroleptic activity.

It also displays a strong affinity as an antagonist to several [[dopamine|dopaminergic]] receptors, but shows only weak antagonism at the dopamine D2 receptor, which is commonly thought to modulate neuroleptic activity.

[https://en.wikipedia.org/wiki/Agranulocytosis Agranulocytosis] (severely low white blood cell count) is a major adverse effect associated with the administration of this agent.

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 '''Clozapine''' (trade names '''Clozaril''' and '''FazaClo''') is an atypical antipsychotic medication that is used to treat severe schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics). Therefore, it is a drug of last resort (DoLR).
-Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or similar disorders (acute delirium, bipolar disorder, extreme cases of anxiety). Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.
+Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or other disorders that can be similar, such as acute delirium, bipolar disorder, and extreme cases of anxiety. However, its only ''approved'' (on-label) use is in treatment-resistant schizophrenia.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.
 ==Chemistry==
 {{chemistry}}
@@ Line 13: / Line 13: @@
 ==Pharmacology==
-Cloazapine classified as an atypical antipsychotic agent. It binds to several types of central nervous system receptors and displays a unique pharmacological profile. It is a [[serotonin]] antagonist, with strong binding to the 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptor subtypes.
+Cloazapine is classified as and was the first atypical antipsychotic agent. It binds to several types of central nervous system receptors and displays a unique pharmacological profile. It is a [[serotonin]] antagonist, with strong binding to the 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptor subtypes.
-It also displays a strong affinity to several [[dopamine|dopaminergic]] receptors, but shows only weak antagonism at the dopamine D2 receptor, which is commonly thought to modulate neuroleptic activity.
+It also displays a strong affinity as an antagonist to several [[dopamine|dopaminergic]] receptors, but shows only weak antagonism at the dopamine D2 receptor, which is commonly thought to modulate neuroleptic activity.
 [https://en.wikipedia.org/wiki/Agranulocytosis Agranulocytosis] (severely low white blood cell count) is a major adverse effect associated with the administration of this agent.