Talk:Clozapine: Difference between revisions

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| ''[[Clozapine/Summary|Summary sheet: Clozapine]]''

Clozapine (trade ~~name~~ '''Clozaril''') is an antipsychotic medication that is used to treat severe schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics). Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or similar disorders (acute delirium, bipolar disorder, extreme cases of anxiety). Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.

Clozapine (trade names '''Clozaril''' and '''FazaClo''') is an atypical antipsychotic medication that is used to treat severe schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics). Therefore, it is a drug of last resort (DoLR). Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or similar disorders (acute delirium, bipolar disorder, extreme cases of anxiety). Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.

==Chemistry==

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor ~~subtype~~. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Clozapine is a tricylic dibenzodiazepine classified as an atypical antipsychotic agent. It binds to several types of central nervous system receptors and displays a unique pharmacological profile. Clozapine is a [[serotonin]] antagonist, with strong binding to the 5-HT 2A/2C receptor subtypes. It also displays strong affinity to several [[dopamine|dopaminergic]] receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. [https://en.wikipedia.org/wiki/Agranulocytosis Agranulocytosis] is a major adverse effect associated with administration of this agent.

~~Year introduced: 1991(1975)~~

===Physical ~~effects~~===

==Subjective effects==

'''{{Preamble/SubjectiveEffects}}'''

===Physical===

*'''[[Effect::Itchiness]]'''

*'''[[Effect::Constipation]]'''

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*'''[[Effect::Headaches]]'''

===Cognitive ~~effects~~===

===Cognitive===

*'''[[Effect::Sleepiness]]'''

*'''[[Effect::Delusions]]'''

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-| image = [[File:Red x.svg|30px|alt=|link=]]
+| image = [[File:Red x.svg|75px|alt=|link=]]
-| text  = Please revise the article immediately. Neither the link format follows our usual format, nor does a summary or detailed substancebox exist.
+| text  = '''Please revise the article immediately. Neither the link format follows our usual format, nor does a summary or detailed substancebox exist.'''
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 |-
 | ''[[Clozapine/Summary|Summary sheet: Clozapine]]''
-Clozapine (trade name '''Clozaril''') is an antipsychotic medication that is used to treat severe schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics). Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or similar disorders (acute delirium, bipolar disorder, extreme cases of anxiety). Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.
+Clozapine (trade names '''Clozaril''' and '''FazaClo''') is an atypical antipsychotic medication that is used to treat severe schizophrenia. However, it only applies to those that have not responded to other medications (studies demonstrated that clozapine was more effective against treatment-resistant schizophrenia than other antipsychotics). Therefore, it is a drug of last resort (DoLR). Clozapine may also be used to help reduce the risk of suicidal tendencies in people with schizophrenia or similar disorders (acute delirium, bipolar disorder, extreme cases of anxiety). Clozapine was first synthesized in 1958 by Wander AG, a Swiss pharmaceutical company, based on the chemical structure of the tricyclic antidepressant imipramine.
 ==Chemistry==
-A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
+Clozapine is a tricylic dibenzodiazepine classified as an atypical antipsychotic agent. It binds to several types of central nervous system receptors and displays a unique pharmacological profile. Clozapine is a [[serotonin]] antagonist, with strong binding to the 5-HT 2A/2C receptor subtypes. It also displays strong affinity to several [[dopamine|dopaminergic]] receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. [https://en.wikipedia.org/wiki/Agranulocytosis Agranulocytosis] is a major adverse effect associated with administration of this agent.
-Year introduced: 1991(1975)
-===Physical effects===
+==Subjective  effects==
+{{effectStub}}
+'''{{Preamble/SubjectiveEffects}}'''
+===Physical===
 *'''[[Effect::Itchiness]]'''
 *'''[[Effect::Constipation]]'''
@@ Line 28: / Line 36: @@
 *'''[[Effect::Headaches]]'''
-===Cognitive effects===
+===Cognitive===
 *'''[[Effect::Sleepiness]]'''
 *'''[[Effect::Delusions]]'''