5F-AKB48: Difference between revisions

{{SubstanceBox/5F-AKB48}}

'''5F-AKB48''' (also known as '''5F-APINACA''') is a synthetic designer [[chemical class::cannabinoid]] that acts as a potent [[agonist]] for the CB1 and CB2 [[cannabinoid]] [[receptor]]s<ref>AKB48 (APINACA) and 5F-AKB48 (5F-APINACA)

  | http://deadiversion.usdoj.gov/drug_chem_info/spice/akb48.pdf</ref>. It produces subjective effects somewhat similar to that of [[cannabis]] with a short duration and an emphasis on intense physical sensations. Its metabolism has been described in the scientific literature.<ref>Simultaneous quantification of 37 [[synthetic cannabinoid]] metabolites in human urine by liquid chromatography-tandem mass spectrometry | http://link.springer.com/article/10.1007%2Fs11419-015-0265-x</ref><ref>Concentrations of APINACA, 5F-APINACA, UR-144 and its degradant product in blood samples from six impaired drivers compared to previous reported concentrations of other [[synthetic cannabinoids]] (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/25485949</ref><ref>Metabolites of 5F-AKB48, a [[synthetic cannabinoid]] receptor agonist, identified in human urine and liver microsomal preparations using liquid chromatography high-resolution mass spectrometry (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/24802286</ref><ref>Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/25721194</ref> It was first identified in South Korea<ref>Synthetic cannabinoids abused in South Korea: drug identifications by the National Forensic Service from 2009 to June 2013 | http://link.springer.com/article/10.1007/s11419-013-0213-6</ref> and is available for sale as a grey area [[research chemical]] through online vendors.