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2C-B-FLY: Difference between revisions

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| ''[[2C-B-FLY/Summary|Summary sheet: 2C-B-FLY]]''
| ''[[2C-B-FLY/Summary|Summary sheet: 2C-B-FLY]]''
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'''2C-B-FLY''' is a [[psychoactive class::psychedelic]] [[chemical class::phenethylamine]] of the [[2C-x]] family which was first synthesized by Aaron P. Monte in 1996.<ref>https://erowid.org/chemicals/2cb_fly/2cb_fly_info1.shtml</ref><ref>http://www.sciencedirect.com/topics/page/2C-B-FLY</ref> It produces psychedelic and mild entactogenic effects which typically last 6–8 hours, or up to 12 hours in larger doses. It presents effects which are similar to [[2C-B]], [[mescaline]] and [[2C-D]].
'''2C-B-FLY''' is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] and [[chemical class::benzodihydrodifuran]] chemical classes that produces a highly dose-sensitive spectrum of [[psychedelic]] and moderate [[entactogenic]] effects which typically last 6–8 hours (or up to 12 hours in larger doses) when [[Route of administration|administered]]. Subjectively, the effects it produces has been compared to those of [[2C-B]], [[mescaline]] and [[MDA]].


Very little is known about this substance, but it gained popularity around 2005 before becoming significantly less common after two deaths occurred in October 2009 after the ingestion of a substance that was mislabeled and sold as 2C-B-FLY but was actually [[Bromo-DragonFLY]].<ref>Information on Reported Deaths Related to 2C-B-FLY | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref>
2C-B-FLY is a derivative of the [[2C-x]] family, specifically [[2C-B]]. It was first synthesized by Aaron P. Monte in 1996.<ref>https://erowid.org/chemicals/2cb_fly/2cb_fly_info1.shtml</ref><ref>http://www.sciencedirect.com/topics/page/2C-B-FLY</ref>. It briefly gained popularity around 2005 before becoming significantly less common after two deaths occurred in October 2009 after the ingestion of a substance that was labeled and sold as 2C-B-FLY actually turned out to be [[Bromo-DragonFLY]],<ref>Information on Reported Deaths Related to 2C-B-FLY | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref> which is an order of magnitude more potent. This led to its immediate withdrawal until around 2016, where it began to be produced and sold again.
 
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B-FLY, and it has little history of human usage. It has no documented history of being sold in the streets and is commercially distributed through online [[research chemical]] vendors. Due to its high potency and sensitive dose-response, many reports also indicate that the effects of this substance should not be seen as a simple substitute for [[2C-B]]. It is highly advised to approach this potent, long-lasting, and unpredictable hallucinogenic substance with the proper amount of precaution and harm reduction practices if one chooses to use it.


It has recently become easily available again through online [[research chemical]] vendors where it is being sold as a [[designer drug]].
==Chemistry==
==Chemistry==
2C-B-FLY is a substituted molecule of the [[phenethylamines|phenethylamine]] and [[benzofuran|dihydrobenzofuran]] classes of drugs. 2C-B-FLY features a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain and contains a bromine atom attached to carbon R<sub>4</sub> of the phenyl ring. 2C-B-FLY is an atypical psychedelic phenethylamine which is closely analogous to [[2C-B]]; it is the dihydrofuran analog to 2C-B, where it incorporates the methoxy groups bound to R<sub>2</sub> and R<sub>5</sub> of 2C-B into five member dihydrofuran rings fused to the central benzene ring.
2C-B-FLY is a substituted molecule of the [[phenethylamine]] and [[dihydrobenzofuran]] chemical classes. 2C-B-FLY features a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain and contains a bromine atom attached to carbon R<sub>4</sub> of the phenyl ring. 2C-B-FLY is an atypical psychedelic phenethylamine which is closely analogous to [[2C-B]]; it is the dihydrofuran analog to 2C-B, where it incorporates the methoxy groups bound to R<sub>2</sub> and R<sub>5</sub> of 2C-B into five member dihydrofuran rings fused to the central benzene ring.


2C-B-FLY belongs to a group of phenethylamine derivatives referred to as the FLY compounds, named for their insect-like appearance of two “wing-like” tetrahydrofuran rings fused on the opposite sides of the central benzene ring. The incorporation of the two methoxy groups into the 5 member rings fixes them into the optimum position for binding to the receptors they interact with resulting in an increase in potency compared to the compound's non-rigid counterpart 2C-B.<ref>http://heffter.org/docs/hrireview/01/chapter5.pdf</ref>
2C-B-FLY belongs to a group of phenethylamine derivatives referred to as the FLY compounds, named for their insect-like appearance of two “wing-like” tetrahydrofuran rings fused on the opposite sides of the central benzene ring. The incorporation of the two methoxy groups into the 5 member rings fixes them into the optimum position for binding to the receptors they interact with resulting in an increase in potency compared to the compound's non-rigid counterpart 2C-B.<ref>http://heffter.org/docs/hrireview/01/chapter5.pdf</ref>
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==Pharmacology==
==Pharmacology==
{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
2C-B-FLY's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. It also has a high binding affinity for the 5-HT<sub>1D</sub>, 5-HT<sub>1E</sub>, 5-HT<sub>1A</sub>, 5-HT<sub>2B</sub> and 5-HT<sub>2C</sub> receptors.<ref>Psychedelics and the human receptorome. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20126400</ref>
Little is known about how the totality of its effects are produced, 2C-B-FLY's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]].


However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain an object of scientific elucidation.
==Subjective effects==
==Subjective effects==
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}


In comparison to [[2C-B]], this compound presents a significantly more pronounced body high/load, stronger visual effects, more complex [[geometry]] and more in-depth [[internal hallucinations|hallucinations]] which are comparable to [[mescaline]], [[2C-E]] or other [[phenethylamine]] psychedelics at higher doses. Lower doses, however, are associated with more [[entactogen]]ic as opposed to classically psychedelic effects.
In comparison to [[2C-B]], this compound presents a significantly more pronounced body high/load, stronger visual effects, more complex [[geometry]] and more in-depth [[internal hallucinations]] which are comparable to [[mescaline]], [[2C-E]] or [[MDA]] at higher doses. Lower doses, however, are associated with more [[entactogenic]] as opposed to classical psychedelic effects.
   
   
===Physical effects===  
===Physical effects===  
The physical effects of 2C-B-FLY are comparable to that of traditional [[phenethylamines]] such as [[2C-E]], [[mescaline]] and [[2C-T-7]].
The physical effects of 2C-B-FLY are comparable to that of traditional [[phenethylamines]] such as [[2C-E]], [[mescaline]] and [[2C-T-7]].


Many people have reported general gastrointestinal disturbances using compound which include [[diarrhoea]], [[nausea]], moderate to severe [[stomach bloating]] and general gassiness at [[moderate]] to [[heavy]] [[dosage]]s. These effects are comparable to that of [[5-MeO-MiPT]], [[2C-T-7]] and other compounds with highly suspected [[MAO]]-altering properties, suggesting that 2C-B-FLY may potentially have such MAO-altering properties of its own, although this has yet to be confirmed.
Many people have reported general gastrointestinal disturbances using compound which include [[diarrhoea]], [[nausea]], moderate to severe [[stomach bloating]] and general gassiness at [[moderate]] to [[heavy]] [[dosages]]. These effects are comparable to that of [[5-MeO-MiPT]], [[2C-T-7]] and other compounds with highly suspected [[MAO]]-altering properties. This suggests that 2C-B-FLY may potentially have such MAO-altering properties of its own, although this has yet to be confirmed.


*'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of 2C-B-FLY can be described as a pleasurable, warm, soft, all-encompassing and mild tingling sensation. This maintains a consistent presence that steadily rises with the [[onset]] and hits its limit once the [[peak]] has been reached. It is comparable to that of a milder [[mescaline]], [[2C-B]] or [[2C-E]] experience.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 2C-B-FLY can be described as a pleasurable, warm, soft, all-encompassing and mild tingling sensation. This maintains a consistent presence that steadily rises with the [[onset]] and hits its limit once the [[peak]] has been reached. It is comparable to that of a milder [[mescaline]], [[2C-B]] or [[2C-E]] experience.
**'''[[Effect::Physical euphoria]]'''
*'''[[Effect::Spontaneous tactile sensations]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Stimulation]]''' and '''[[Effect::Sedation]]''' - At [[light]] [[dosage]]s, this compound is generally stimulating but in a gentle, non-forceful manner similar to that of [[2C-B]] or [[mescaline]]. However, at [[heavy|heavier]] dosages one may find the amount of stimulation to increase to uncomfortable degrees if not feeling significantly sedated in a manner similar to that of [[2C-C]] or one of the many compounds in the [[2C-T]] series, most prominently [[2C-T-7]].
*'''[[Effect::Stimulation]]''' and '''[[Effect::Sedation]]''' - At [[light]] [[dosage]]s, this compound is generally stimulating but in a gentle, non-forceful manner similar to that of [[2C-B]] or [[mescaline]]. However, at [[heavy|heavier]] dosages one may find the amount of stimulation to increase to uncomfortable degrees if not feeling significantly sedated in a manner similar to that of [[2C-C]] or one of the many compounds in the [[2C-T]] series, most prominently [[2C-T-7]].
*'''[[Effect::Temperature regulation suppression]]'''
**'''[[Effect::Increased temperature]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Bodily pressures]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Headaches]]'''
*'''[[Effect::Muscle cramps]]'''
*'''[[Effect::Stomach bloating]]'''
*'''[[Effect::Stomach cramps]]'''
*'''[[Effect::Nausea]]'''
*'''[[Effect::Nausea]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Diarrhea]]'''  
*'''[[Effect::Diarrhea]]'''  
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Excessive yawning]]'''
*'''[[Effect::Watery eyes]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Teeth grinding]]'''
*'''[[Effect::Stomach  bloating]]'''


===Cognitive effects===
===Cognitive effects===
It is worth noting that despite the potential cognitive effects of 2C-B-FLY, it tends to maintain a level of relatively normal and sober thought structure regardless of the subjective visual, physical and cognitive accompanying effects intensity. This leaves the user in control in a manner which would not be possible on many compounds such as [[4-AcO-DMT]], [[psilocin]] or [[LSD]] due to their accompanying [[confusion]] and [[delusion]]s.
It is worth noting that despite the potential cognitive effects of 2C-B-FLY, it tends to maintain a level of relatively normal and sober thought structure regardless of the subjective visual, physical and cognitive accompanying effects intensity. This leaves the user in control in a manner which would not be possible on many compounds such as [[4-AcO-DMT]], [[psilocin]] or [[LSD]] due to their accompanying [[confusion]] and [[delusion]]s.
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Disinhibition]]'''
*'''[[Effect::Empathy, love, and sociability enhancement]]''' - This compound presents entactogenic effects on a level which is less intense than that of [[2C-B]] or [[MDMA]] but similar in quality to that of [[mescaline]] or [[2C-E]].
*'''[[Effect::Emotionality enhancement]]'''
*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This compound presents entactogenic effects on a level which is less intense than that of [[2C-B]] or [[MDMA]] but similar in quality to that of [[mescaline]] or [[2C-E]].
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Mindfulness]]
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Spirituality enhancement]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Unity and interconnectedness]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Wakefulness]]'''


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*'''[[Effect::Pattern recognition enhancement]]'''
*'''[[Effect::Pattern recognition enhancement]]'''
*'''[[Effect::Visual acuity enhancement]]'''
*'''[[Effect::Visual acuity enhancement]]'''
====Distortions====
====Distortions====
*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Breathing|breathing]], [[Drifting#Morphing|morphing]] and [[Drifting#Flowing|flowing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, intricate in appearance and unrealistic/cartoon-like in style. It is very comparable to that of [[2C-B]] or [[mescaline]].
*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Breathing|breathing]], [[Drifting#Morphing|morphing]] and [[Drifting#Flowing|flowing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, intricate in appearance and unrealistic/cartoon-like in style. It is very comparable to that of [[2C-B]] or [[mescaline]].
*'''[[Effect::Tracers]]'''
*'''[[Effect::After images]]'''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Depth perception distortions]]'''
*'''[[Effect::Depth perception distortions]]'''
*'''[[Effect::Perspective distortions]]'''
*'''[[Effect::Perspective distortions]]'''
*'''[[Effect::Symmetrical texture repetition]]'''
*'''[[Effect::Symmetrical texture repetition]]'''
*'''[[Effect::Tracers]]'''
 
====[[Effect::Geometry]]====
====[[Effect::Geometry]]====
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[mescaline]], [[2C-B]] and [[2C-D]] than [[psilocin]] or [[ayahuasca]]. It can be comprehensively described through its [[Geometry#Variations|style variations]] as intricate in complexity, abstract in form, synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, flat in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. They have a a contradictory combination of a very "natural" but also "neon digital" feel to them and at higher dosages are significantly more likely to result in states of [[Geometry#8B_-_Exposure_to_inner_mechanics_of_consciousness|level 8B]] visual geometry over [[Geometry#8A_-_Exposure_to_semantic_concept_network|level 8A]].
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[mescaline]], [[2C-B]] and [[2C-D]] than [[psilocin]] or [[ayahuasca]]. It can be comprehensively described through its [[Geometry#Variations|style variations]] as intricate in complexity, abstract in form, synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, flat in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in-depth and consistent in intensity. They have a contradictory combination of a very "natural" but also "neon digital" feel to them and at higher dosages are significantly more likely to result in states of [[Geometry#8B_-_Exposure_to_inner_mechanics_of_consciousness|level 8B]] visual geometry over [[Geometry#8A_-_Exposure_to_semantic_concept_network|level 8A]].


====Hallucinatory states====
====Hallucinatory states====
2C-B-FLY produces a full range of high level hallucinatory states in a fashion that is comparable to [[mescaline]] or [[2C-E]]. This is more consistent and reproducible than that of many other commonly used psychedelics such as [[2C-B]] or [[LSD]]. It tends to occur at heavier dosages and integrates seamlessly with the accompanying geometry. These effects generally include:  
2C-B-FLY produces a moderate range of hallucinatory states in a fashion that is comparable to [[mescaline]] or common doses of [[2C-E]]. This is more consistent and reproducible than that of many other commonly used psychedelics such as [[2C-B]] or [[LSD]]. It tends to occur at heavier dosages and integrates seamlessly with the accompanying geometry. These effects generally include:  
 
*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
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* [https://www.erowid.org/experiences/subs/exp_2CBFly.shtml Erowid Experience Vaults: 2C-B-FLY]
* [https://www.erowid.org/experiences/subs/exp_2CBFly.shtml Erowid Experience Vaults: 2C-B-FLY]


==Potentially Dangerous interactions==
==Toxicity and harm potential==
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 2C-B-FLY do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-B-FLY is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 2C-B-FLY suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
 
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
===Tolerance and addiction potential===
2C-B-FLY is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.
 
Tolerance to the effects of 2C-B-FLY are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 2C-B-FLY presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-B-FLY all psychedelics will have a reduced effect.
 
===Dangerous interactions===
{{Template:DangerousInteractions/Intro}}
{{Template:DangerousInteractions/Intro}}


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==Toxicity and harm potential==
==Legality==
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 2C-B-FLY do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-B-FLY is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 2C-B-FLY suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
 
"It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the administration of the intended dose.
===Tolerance and addiction potential===
2C-B-FLY is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.
 
Tolerance to the effects of 2C-B-FLY are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 2C-B-FLY presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-B-FLY all psychedelics will have a reduced effect.
 
==Legal issues==
{{legalStub}}
{{legalStub}}
*'''United States''' - 2C-B-FLY is unscheduled and uncontrolled in the United States. However, it may fall under the scope of the Federal Analog Act if it is intended for human consumption given its similarity to 2C-B.
*'''United States''' - 2C-B-FLY is unscheduled and uncontrolled in the United States. However, it may fall under the scope of the Federal Analog Act if it is intended for human consumption given its similarity to 2C-B.
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==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
**[[Volumetric dosing]]
*[[Psychedelics]]
*[[Psychedelics]]
*[[Phenethylamines]]
*[[Phenethylamines]]
*[[Bromo-DragonFLY]]
*[[2C-x]]
*[[2C-x]]
*[[2C-B]]
*[[2C-B]]
*[[Bromo-DragonFLY]]


==External links==
==External links==
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==References==
==References==
<references />
<references />
[[Category:Psychoactive substance]]
[[Category:Hallucinogen]]
[[Category:Psychedelic]]
[[Category:Phenethylamine]]
[[Category:Phenethylamine]]
[[Category:Psychedelic]]
[[Category:Benzodihydrofuran]]
[[Category:Psychoactive substance]]
Retrieved from "https://psy.st/wiki/2C-B-FLY"