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MAOI: Difference between revisions
>David Hedlund |
>David Hedlund →Toxicity and harm potential: move sections about psychoactive substances under ===Dangerous interactions=== |
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When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose. | When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose. | ||
=== | ===Dangerous interactions=== | ||
{{DangerousInteractions/Intro}} | |||
{{DangerousInteractions/MAOIs}} | |||
====Psychoactive naturally occurring sources with high tyramine content==== | |||
*[[Psychedelic cacti]]. The cacti contain contain a bunch of phenethylamines, not just tyramine (but also 3-Methoxytyramine, methyltyramine, hordenine (aka dimethyltyramine), mescaline, etc) and should thus be avoided with MAOIs. However, tyramine has been identified in these species: | *[[Psychedelic cacti]]. The cacti contain contain a bunch of phenethylamines, not just tyramine (but also 3-Methoxytyramine, methyltyramine, hordenine (aka dimethyltyramine), mescaline, etc) and should thus be avoided with MAOIs. However, tyramine has been identified in these species: | ||
**[[Echinopsis peruviana|Peruvian torch cactus (''Echinopsis peruviana'' (syn. ''Trichocereus peruvianus''))]]<ref name="pubmed-600028">{{cite journal | vauthors=((Pardanani, J. H.)), ((McLaughlin, J. L.)), ((Kondrat, R. W.)), ((Cooks, R. G.)) | journal=Lloydia | title=Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus | volume=40 | issue=6 | pages=585–590 | date= December 1977 | issn=0024-5461}}</ref> | **[[Echinopsis peruviana|Peruvian torch cactus (''Echinopsis peruviana'' (syn. ''Trichocereus peruvianus''))]]<ref name="pubmed-600028">{{cite journal | vauthors=((Pardanani, J. H.)), ((McLaughlin, J. L.)), ((Kondrat, R. W.)), ((Cooks, R. G.)) | journal=Lloydia | title=Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus | volume=40 | issue=6 | pages=585–590 | date= December 1977 | issn=0024-5461}}</ref> | ||
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===Psychoactive substances=== | ====Psychoactive substances==== | ||
The MAOIs are well-known for their numerous drug interactions, including the following kinds of substances: | The MAOIs are well-known for their numerous drug interactions, including the following kinds of substances: | ||
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====By chemicals==== | ====By chemicals==== | ||
*Amino acids, and amino acid metabolism metabolic intermediates | *Amino acids, and amino acid metabolism metabolic intermediates | ||
**Monoamine precursors | **Monoamine precursors | ||
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====Over-the-counter (OTC) medicines==== | ====Over-the-counter (OTC) medicines==== | ||
====Tyramine==== | ====Tyramine==== | ||