Talk:Olanzapine: Difference between revisions

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[[File:Olanzapine.svg|250px|thumbnail|right|Structure of olanzapine.]]

[[File:Apotex-manufactured olanzapine 5 mg ODT.jpg|400px|thumbnail|right|A five milligram tablet of olanzapine manufactured by Apotex. This tablet is designed to dissolve in the mouth and be absorbed through the blood vessels inside of the mouth.]]

'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine is known to cause weight gain and help induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref> Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] ~~Telenzepine is another agent that shares the thienobenzodiazepine core structure.~~ Olanzapine as useful as a trip aborter, especially for stimulants.

'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. {{citation needed}}

~~:(doses:~~

==Chemistry==

~~:Light:~~ 2.~~5 mg~~

Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety.

~~:Medium: 5~~ to 7.~~5 mg~~

:~~Heavy: 10 mg~~

==Pharmacology==

~~:Strong: 10 mg +~~)

Olanzapine is known to cause weight gain and induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref>

==Subjective effects==

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*'''[[Sleepiness]]'''

*'''[[Cognitive euphoria]]''' - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.

*'''[[Cognitive dysphoria]]''' - This often includes ~~an extreme~~ sense of boredom or depression accompanied by uncomfortable sedation.

*'''[[Cognitive dysphoria]]''' - This often includes a sense of boredom or depression accompanied by uncomfortable sedation.

}}

==not the crème de là crème==

:(doses:

:Light: 2.5 mg

:Medium: 5 to 7.5 mg

:Heavy: 10 mg

:Strong: 10 mg +)

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 [[File:Olanzapine.svg|250px|thumbnail|right|Structure of olanzapine.]]
 [[File:Apotex-manufactured olanzapine 5 mg ODT.jpg|400px|thumbnail|right|A five milligram tablet of olanzapine manufactured by Apotex. This tablet is designed to dissolve in the mouth and be absorbed through the blood vessels inside of the mouth.]]
-'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine is known to cause weight gain and help induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref> Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Telenzepine is another agent that shares the thienobenzodiazepine core structure. Olanzapine as useful as a trip aborter, especially for stimulants.
+'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. {{citation needed}}
-:(doses:
+==Chemistry==
-:Light: 2.5 mg
+Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety.
-:Medium: 5 to 7.5 mg
-:Heavy: 10 mg
+==Pharmacology==
-:Strong: 10 mg +)
+Olanzapine is known to cause weight gain and induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref>
 ==Subjective effects==
@@ Line 32: / Line 33: @@
 *'''[[Sleepiness]]'''
 *'''[[Cognitive euphoria]]''' - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.
-*'''[[Cognitive dysphoria]]''' - This often includes an extreme sense of boredom or depression accompanied by uncomfortable sedation.
+*'''[[Cognitive dysphoria]]''' - This often includes a sense of boredom or depression accompanied by uncomfortable sedation.
 }}
 }}
+==not the crème de là crème==
+:(doses:
+:Light: 2.5 mg
+:Medium: 5 to 7.5 mg
+:Heavy: 10 mg
+:Strong: 10 mg +)