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Talk:Clozapine: Difference between revisions
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{{SubstanceBox/Clozapine}} | {{SubstanceBox/Clozapine}} | ||
[[File:FazaClo and Clozaril 100 mg each side by side.png|400px|thumbnail|right|FazaClo and Clozaril 100 mg tablets.]] | |||
'''Clozapine''', sold '''Clozaril''' and '''FazaClo''', is an [[antipsychotic|atypical antipsychotic]] substance of the tricyclic dibenzodiazepine chemical class that produces antipsychotic, hypnotic, and dulling effects when administered. It is used for treatment-resistant schizophrenia and is considered to be a "drug of last resort," reserved for when all other agents have failed.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> It is also used for schizoaffective disorder, a similar condition. FazaClo is an orally disintegrating tablet. <ref>Jazz Pharmaceuticals (2017) FazaClo Highlights of Prescribing Information</ref> | '''Clozapine''', sold '''Clozaril''' and '''FazaClo''', is an [[antipsychotic|atypical antipsychotic]] substance of the tricyclic dibenzodiazepine chemical class that produces antipsychotic, hypnotic, and dulling effects when administered. It is used for treatment-resistant schizophrenia and is considered to be a "drug of last resort," reserved for when all other agents have failed.<ref> Novartis Corporation, Prescribing Guide For Clozapine (https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf)</ref> It is also used for schizoaffective disorder, a similar condition. FazaClo is an orally disintegrating tablet. <ref>Jazz Pharmaceuticals (2017) FazaClo Highlights of Prescribing Information</ref> | ||
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*'''[[Effect::Increased heart rate]]''' - Clozapine's anticholinergic activity increases heart rate. | *'''[[Effect::Increased heart rate]]''' - Clozapine's anticholinergic activity increases heart rate. | ||
*'''[[Effect::Motor control loss]]''' - This effect is usually mild. | *'''[[Effect::Motor control loss]]''' - This effect is usually mild. | ||
*'''[[Effect::Weight gain]]''' | |||
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{{effects/visual| | {{effects/visual| | ||
*'''[[Effect::External hallucinations|Hallucinations]]''' - These only occur in high doses and as a result of clozapine's anticholinergic activity. | *'''[[Effect::External hallucinations|Hallucinations]]''' - These only occur in very high doses and as a result of clozapine's anticholinergic activity. | ||
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{{effects/paradoxical| | |||
Paradoxical reactions to antipsychotics such as worsened psychosis, violent behavior, loss of impulse control, irritability, and suicidal behavior sometimes occur (although they are rare in the general population).{{citation needed}} | |||
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