This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Efavirenz: Difference between revisions
>Kenan |
>Unity SummarySheet, Approval Tags, Grammatics. |
||
| Line 1: | Line 1: | ||
{{headerpanel| {{ | {{headerpanel| {{approval}}}} | ||
{{ | {{SummarySheet}} | ||
{ | {{SubstanceBox/Efavirenz}} | ||
'''Efavirenz''' (also known by the brand name '''Sustiva''') is a non-nucleotide reverse transcriptase inhibitor used in the treatment and prevention of human immunodeficiency virus infections type 1 (HIV-1). Efavirenz is notable for having a strange array of effects, many resembling [[psychedelic]] substance, as well as an extremely novel pharmacological profile and chemical structure. | |||
'''Efavirenz''' (also known by the brand name '''Sustiva''') is a non-nucleotide reverse transcriptase inhibitor used in the treatment and prevention of human immunodeficiency virus infections type 1 (HIV-1). Efavirenz is notable for having a strange array of effects, many resembling [[ | |||
==Chemistry== | ==Chemistry== | ||
| Line 69: | Line 66: | ||
*'''[[Effect::Auditory distortion|Distortions]]''' | *'''[[Effect::Auditory distortion|Distortions]]''' | ||
*'''[[Effect::Auditory hallucinations|Hallucinations]]''' | *'''[[Effect::Auditory hallucinations|Hallucinations]]''' | ||
==Potentially dangerous interactions== | |||
As efavirenz may cause hepatoxicity at high doses or after chronic use, it is not recommended to take this substance concurrently with other substances that may cause hepatoxicity. Efavirenz is an inducer of the CYP2B6 and CYP3A4 enzymes of the cytochrome P450 system, and as a result may change the metabolism of drugs metabolized by them. Consuming garlic may decrease serum levels of efavirenz. | |||
====[[Serotonin syndrome]] risk==== | |||
Efavirenz is a weak serotonin reuptake inhibitor, so it is possible that combining heavy doses of efavirenz and the substances listed below may result in serotonin syndrome. | |||
{{DangerousInteractions/SerotoninSyndrome}} | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
| Line 77: | Line 81: | ||
Efavirenz is [[Addiction potential::not known to be habit-forming]]. While developing a tolerance to efavirenz is extremely rare, abusing efavirenz may cause HIV to become resistant to the drug and increase the viral load in patients with HIV. | Efavirenz is [[Addiction potential::not known to be habit-forming]]. While developing a tolerance to efavirenz is extremely rare, abusing efavirenz may cause HIV to become resistant to the drug and increase the viral load in patients with HIV. | ||
==Legal issues== | ==Legal issues== | ||