Dangerous combinations: Difference between revisions

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[[File:TripSit's Dangerous combination chart.png|400px|thumb|right|A useful chart from [www.tripsit.me TripSit.me] which can be used to identify dangerous drug combinations quickly and easily.]]

Although many ~~drugs~~ are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

Drug related deaths most commonly occur when combining [[depressant]]s. Depressants affect parts of the brain that are responsible for respiration, and an overdose or combination of these ~~drugs~~ can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to suffocate from their own vomit. Lying in the [[recovery position]] can prevent one from inhaling their own vomit.

Drug related deaths most commonly occur when combining [[depressant]]s. Depressants affect parts of the brain that are responsible for respiration, and an overdose or combination of these substances can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to suffocate from their own vomit. Lying in the [[recovery position]] can prevent one from inhaling their own vomit.

[[File:Standard-recovery-position.jpg|230px|thumbnail|Lying in the [[recovery position]] can prevent one from inhaling their own vomit.]]

Another possibly fatal combination of ~~drugs~~ are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said drug. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI).

Another possibly fatal combination of substances are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said drug. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI).

== Depressants ==

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*'''[[Stimulants]]''' - It is dangerous to combine alcohol, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. This combination can also potentially result in severe dehydration if hydration is not monitored. It also interacts with [[cocaine]] in vivo to produce [[Cocaine#Interactions|cocaethylene]], another psychoactive substance.<ref>Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases | http://dmd.aspetjournals.org/content/31/1/16</ref>

*'''[[MAOI]]'''s - This combination can result in dangerous reactions through the way in which tyramine, a chemical commonly found in alcoholic beverages, causes [[increased blood pressure]].

== Serotonergic ~~drugs~~ ==

== Serotonergic substances ==

===[[MAOI|Monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI) ===

@@ Line 3: / Line 3: @@
 [[File:TripSit's Dangerous combination chart.png|400px|thumb|right|A useful chart from [www.tripsit.me TripSit.me] which can be used to identify dangerous drug combinations quickly and easily.]]
-Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. Certain combinations may be safe in low doses of each but still increase the potential risk of death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
-Drug related deaths most commonly occur when combining [[depressant]]s. Depressants affect parts of the brain that are responsible for respiration, and an overdose or combination of these drugs can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to suffocate from their own vomit. Lying in the [[recovery position]] can prevent one from inhaling their own vomit.
+Drug related deaths most commonly occur when combining [[depressant]]s. Depressants affect parts of the brain that are responsible for respiration, and an overdose or combination of these substances can result in fatal levels of [[respiratory depression]]. Death may also occur when a victim falls into deep enough unconsciousness to suffocate from their own vomit. Lying in the [[recovery position]] can prevent one from inhaling their own vomit.
 [[File:Standard-recovery-position.jpg|230px|thumbnail|Lying in the [[recovery position]] can prevent one from inhaling their own vomit.]]
-Another possibly fatal combination of drugs are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said drug. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI).
+Another possibly fatal combination of substances are [[serotonin|serotonergic]] substances, which might cause [[serotonin syndrome]]. This can also be caused alone by an overdose of said substances. [[Serotonin syndrome]] is a result of excess [[serotonin]] in the brain, which can cause [[seizures]], [[anxiety]], tremors, [[nausea]], coma and possibly a deadly fever. Usually this is caused when a user has used an [[anti-depressant]] within the last 2 weeks of consuming said drug. These kind of antidepressants include [[MAOI|monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI).
 == Depressants ==
@@ Line 23: / Line 23: @@
 *'''[[Stimulants]]''' -  It is dangerous to combine alcohol, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of alcohol, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified [[disinhibition]] as well as [[Alcohol#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour. This combination can also potentially result in severe dehydration if hydration is not monitored. It also interacts with [[cocaine]] in vivo to produce [[Cocaine#Interactions|cocaethylene]], another psychoactive substance.<ref>Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases | http://dmd.aspetjournals.org/content/31/1/16</ref>
 *'''[[MAOI]]'''s - This combination can result in dangerous reactions through the way in which tyramine, a chemical commonly found in alcoholic beverages, causes [[increased blood pressure]].
-== Serotonergic drugs ==
+== Serotonergic substances ==
 ===[[MAOI|Monoamine oxidase inhibitors (MAOIs)]], [[serotonin reuptake inhibitor]]s (SSRIs) and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRI) ===