STS-135: Difference between revisions - PsychonautWiki Archive

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Unlike [[cannabis]], the chronic abuse of [[synthetic cannabinoids]] has been [[Synthetic_cannabinoid#Deaths|associated with multiple deaths]] and [[Synthetic cannabinoid#Harm potential|more dangerous side effects and toxicity]] in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.

==Chemistry==

STS-135, or N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, is a synthetic [[chemical class::cannabinoid]] drug containing a substituted indole group. This indole moeity is substituted at R1 with a fluoropentyl chain, a substitution shared with [[5F-PB-22]], [[THJ-2201]], and [[5F-~~AKB-48~~]]. Additionally, the indole is substituted at R3 with a carboxamide group. This carboxamide group is N-substituted at its terminal amine group with an adamantane group. This group consists of four fused cyclohexane rings in a unique structure called a diamondoid. STS-135 is an analog of [[5F-~~AKB-48~~]] in which the core indazole structure is substituted with an indole base.

STS-135, or N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, is a synthetic [[chemical class::cannabinoid]] drug containing a substituted indole group. This indole moeity is substituted at R1 with a fluoropentyl chain, a substitution shared with [[5F-PB-22]], [[THJ-2201]], and [[5F-AKB48]]. Additionally, the indole is substituted at R3 with a carboxamide group. This carboxamide group is N-substituted at its terminal amine group with an adamantane group. This group consists of four fused cyclohexane rings in a unique structure called a diamondoid. STS-135 is an analog of [[5F-AKB48]] in which the core indazole structure is substituted with an indole base.

==Pharmacology==

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 Unlike [[cannabis]], the chronic abuse of [[synthetic cannabinoids]] has been [[Synthetic_cannabinoid#Deaths|associated with multiple deaths]] and [[Synthetic cannabinoid#Harm potential|more dangerous side effects and toxicity]] in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.
 ==Chemistry==
-STS-135, or N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, is a synthetic [[chemical class::cannabinoid]] drug containing a substituted indole group. This indole moeity is substituted at R<sub>1</sub> with a fluoropentyl chain, a substitution shared with [[5F-PB-22]], [[THJ-2201]], and [[5F-AKB-48]]. Additionally, the indole is substituted at R<sub>3</sub> with a carboxamide group.  This carboxamide group is N-substituted at its terminal amine group with an adamantane group. This group consists of four fused cyclohexane rings in a unique structure called a diamondoid. STS-135 is an analog of [[5F-AKB-48]] in which the core indazole structure is substituted with an indole base.
+STS-135, or N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, is a synthetic [[chemical class::cannabinoid]] drug containing a substituted indole group. This indole moeity is substituted at R<sub>1</sub> with a fluoropentyl chain, a substitution shared with [[5F-PB-22]], [[THJ-2201]], and [[5F-AKB48]]. Additionally, the indole is substituted at R<sub>3</sub> with a carboxamide group.  This carboxamide group is N-substituted at its terminal amine group with an adamantane group. This group consists of four fused cyclohexane rings in a unique structure called a diamondoid. STS-135 is an analog of [[5F-AKB48]] in which the core indazole structure is substituted with an indole base.
 ==Pharmacology==