MAOI: Difference between revisions - PsychonautWiki Archive

Line 5:

MAOIs act by inhibiting the activity of monoamine oxidase, preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates [[serotonin]], [[melatonin]], [[adrenaline]], and [[noradrenaline]]. MAO-B preferentially deaminates phenylethylamine and trace amines. [[Dopamine]] is equally deaminated by both types.

===Reversibility===

The early MAOIs inhibit monoamine oxidase irreversibly. When they react with monoamine oxidase, they permanently deactivate it and the enzyme cannot function until it has been replaced by the body, which can take about two weeks. A few newer MAOIs (known as [[RIMA|RIMAs]] are reversible, meaning that they are able to detach from the enzyme to facilitate usual catabolism of the substrate.

The early MAOIs inhibit monoamine oxidase irreversibly. When they react with monoamine oxidase, they permanently deactivate it and the enzyme cannot function until it has been replaced by the body, which can take about two weeks. A few newer MAOIs (known as [[RIMA|RIMAs]]) are reversible, meaning that they are able to detach from the enzyme to facilitate usual catabolism of the substrate.

==Interactions==

@@ Line 5: / Line 5: @@
 MAOIs act by inhibiting the activity of monoamine oxidase, preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates [[serotonin]], [[melatonin]], [[adrenaline]], and [[noradrenaline]]. MAO-B preferentially deaminates phenylethylamine and trace amines. [[Dopamine]] is equally deaminated by both types.
 ===Reversibility===
-The early MAOIs inhibit monoamine oxidase irreversibly. When they react with monoamine oxidase, they permanently deactivate it and the enzyme cannot function until it has been replaced by the body, which can take about two weeks. A few newer MAOIs (known as [[RIMA|RIMAs]] are reversible, meaning that they are able to detach from the enzyme to facilitate usual catabolism of the substrate.
+The early MAOIs inhibit monoamine oxidase irreversibly. When they react with monoamine oxidase, they permanently deactivate it and the enzyme cannot function until it has been replaced by the body, which can take about two weeks. A few newer MAOIs (known as [[RIMA|RIMAs]]) are reversible, meaning that they are able to detach from the enzyme to facilitate usual catabolism of the substrate.
 ==Interactions==