STS-135: Difference between revisions - PsychonautWiki Archive

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'''STS-135''' ('''N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide''') is a drug that acts as a potent [[agonist]] for the [[cannabinoid]] receptors which produces subjective effects somewhat similar to that of cannabis with a short duration and an emphasis on intense physical sensations. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it is available for sale as a grey area research chemical through online vendors.

'''STS-135''' ('''N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide''', also called '''5F-APICA''') is a drug that acts as a potent [[agonist]] for the [[cannabinoid]] receptors which produces subjective effects somewhat similar to that of cannabis with a short duration and an emphasis on intense physical sensations. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it is available for sale as a grey area research chemical through online vendors.

==Chemistry==

==Pharmacology==

Although this substance has not been formally studied, from analysis of the structure, it is presumed that STS-135 has a similar binding profile to that of other [[cannibanoids]] and matches many of the in vivo properties of [[Δ9-THC]].

Formal studies have demonstrated that STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors.<ref>Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 | http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00107</ref> STS-135 produces bradycardia and hypothermia in rats at doses of 1-10 mg/kg, suggesting cannabinoid-like activity.<ref>Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 | http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00107</ref> However, the role of these interactions and how they result in the cannabinoid high experience continues to remain elusive.

==Subjective effects==

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 {{SubstanceBox/STS-135}}
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-'''STS-135''' ('''N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide''') is a drug that acts as a potent [[agonist]] for the [[cannabinoid]] receptors which produces subjective effects somewhat similar to that of cannabis with a short duration and an emphasis on intense physical sensations. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it is available for sale as a grey area research chemical through online vendors.
+'''STS-135''' ('''N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide''', also called '''5F-APICA''') is a drug that acts as a potent [[agonist]] for the [[cannabinoid]] receptors which produces subjective effects somewhat similar to that of cannabis with a short duration and an emphasis on intense physical sensations. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it is available for sale as a grey area research chemical through online vendors.
 ==Chemistry==
 {{chemistry}}
 ==Pharmacology==
 Although this substance has not been formally studied, from analysis of the structure, it is presumed that STS-135 has a similar binding profile to that of other [[cannibanoids]] and matches many of the in vivo properties of [[Δ9-THC]].
+Formal studies have demonstrated that STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors.<ref>Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 | http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00107</ref> STS-135 produces bradycardia and hypothermia in rats at doses of 1-10 mg/kg, suggesting cannabinoid-like activity.<ref>Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135 | http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00107</ref> However, the role of these interactions and how they result in the cannabinoid high experience continues to remain elusive.
 ==Subjective effects==