Talk:Glaucine: Difference between revisions

 

Glaucine is a naturally occurring novel [[psychedelic]] substance of the [[aporphine]] class found in ''[[Glaucium Flavum]]''.<ref>https://link.springer.com/article/10.1023/B:PHAC.0000048907.58847.c6</ref> Glaucine has one stereocenter, therefore it has two stereoisomers, where (S)-Glaucine is a 5-HT_2A  [[agonist]] and (R)-Glaucine is a 5-HT₂ positive allosteric modulator.<ref name=":1">https://onlinelibrary.wiley.com/doi/10.1111/cbdd.13390</ref> Its psychedelic effects are believed to be produced by its interaction with [[serotonin]] [[Receptor|receptors]] like most psychedelics do, but also has clinically significant interactions at D1<ref>https://www.sciencedirect.com/science/article/abs/pii/S0968089605002312?via%3Dihub</ref> and α1<ref name=":2">https://pubmed.ncbi.nlm.nih.gov/30216681/</ref> receptors as an [[antagonist]], and inhibits MOA to a moderate degree.<ref>https://www.sciencedirect.com/science/article/abs/pii/S0021967319301104?via%3Dihub</ref> Glaucine has a close relative found in [[Blue Lotus]] (''Nymphaea nouchali)'' called [[apomorphine]]. It is both psychedelic as well as sedating, but the [[sedation]] is more similar to that of [[opioids]] than [[Psilocybin mushrooms|psilocybin]], a generally sedating psychedelic. It is most commonly consumed [[Routes of administration|orally]].

 

Due to its potent sedating effects as well as unknown toxicity profile, it is strongly recommended that one use proper [[Responsible drug use|harm reduction practices]] if choosing to use this substance.

Glaucine was first described in 1839 by Probst, defined as an 'acrid [[alkaloid]], and was first isolated by Richard Fischer in 1901.<ref name=":0">https://minds.wisconsin.edu/bitstream/handle/1793/71908/KETCHAM.pdf?sequence=1&isAllowed=y#:~:text=(1)%20The%20earliest%20chemical%20investigation,which%20he%20called%20Glaucopicrin%2C%203.</ref> It has been used used for millennia, where records back to the year 131 claim it was used for aches and sores as well as abscess' in present-day Turkey.<ref name=":0" /> In an overview study in 2007, glaucine's antitussive effectiveness was confirmed along with its potent [[bronchodilation]] effects, but lacked the [[Respiratory depression|respiratory depression]] and habit-forming use associated with opioid antitussives.<ref>https://www.sciencedirect.com/science/article/abs/pii/B9780080552323618252?via%3Dihub</ref> Today, it is sold as an antitussive medicine in Iceland and eastern European countries, as well as being used off-label for asthma.<ref>https://link.springer.com/article/10.1007/s00228-007-0451-9</ref> It has very few written experiences online, but the earliest found is from 2009.<ref>https://www.erowid.org/experiences/subs/exp_Glaucine.shtml</ref>{{historyStub}}

Glaucine is a sedative-psychedelic. The psychedelic effects perceived from glaucine are in fact from interaction of 5-HT_2A receptors, but both stereoisomers of glaucine interact with the receptor differently. (S)-glaucine is an agonist of the receptor, the same action performed by psychedelics like [[LSD]] and [[mescaline]], but (R)-glaucine is a positive allosteric modulator, meaning it boosts the signaling and activity at the receptor.<ref name=":1" /> Its sedating effects are believed to come from its strong antagonism at α1 receptors, the same receptors that the stimulant [[caffeine]] agonizes.<ref name=":2" /> D1 antagonism is common amongst aporphines such as apomorphine, and might be a cause of reduction in drug-seeking behaviors following administration such as seen with apomorphine.<ref>https://apomorphine.info/</ref>{{pharmacology}}

Glaucine can be described as a warm and encompassing body high with an especially prominent euphoria. The body high can be described as more opiate-like than psychedelic, preferring physical euphoria over tactile sensations.

*'''[[Effect::Increased respiration]]''' - Potent bronchodilation allows for a more vast airflow, though the feeling is uncomfortable and might feel like one is suffocating.

*'''[[Effect::Perception of bodily heaviness]]'''

*'''[[Effect::Physical euphoria]]''' - It is usually felt as a warm encompassment of the body.

*'''[[Effect::Pupil dilation]]''' - Serotonergic substances are known to cause pupil dilation.

Glaucine visuals are subtle, slow, encompassing, and conform to current patterns and scenery.

*'''[[Effect::Pattern recognition enhancement]]'''

There are currently {{#ask:[[Category:Glaucine]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]]. Additional experience reports can be found here:

*[https://www.erowid.org/experiences/subs/exp_Glaucine.shtml Erowid Experience Vaults: Glaucine]

Intragastrical administration of glaucine to rats in doses of 5, 25 and 75 mg/kg bodyweight daily for 3 months did not produce any detectable harm to any organ. It has also been concluded that it is not an allergen, mutagenic, or toxic to embryos.<ref>https://pubmed.ncbi.nlm.nih.gov/6617832/</ref>{{toxicity}}

*[https://en.wikipedia.org/wiki/Glaucine Glaucine (Wikipedia)]