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{{Experience reports|erowid_experience_substance_label=2-Methylmethcathinone}}
 
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{{SummarySheet}}
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{{SubstanceBox/2-MMC}}
{{SubstanceBox/2-MMC}}
'''2-Methylmethcathinone''' (also known as '''2-MMC''', '''Ortho'''  or '''Orthomephedrone''') is a novel lesser-known stimulant-entactogen substance of the [[cathinones|cathinone]] class that induces  feelings of [[physical euphoria|euphoria]], and [[stimulation]]. It is related to other substituted cathinones like for example [[3-MMC]] or [[4-MMC]] (Mephedrone). The mechanism of action is not fully studied, but [[dopamine]], [[serotonin]] and [[norepinephrine]] releasing activity is known to be involved.
2-MMC is shown to be more dopaminergic and less serotonergic compared to [[MDMA]]. This profile makes it more stimulating and less empathogenic, similar to that of [[Amphetamine]].
[[Subjective effects]] include [[stimulation]], [[anxiety suppression]], [[empathy, affection, and sociability enhancement|enhanced empathy and sociability]], [[muscle relaxation|relaxation]], [[increased libido]], [[increased music appreciation]] and [[euphoria]]. The effects are reported to be a mix of amphetamine and a cocaine-like stimulation rush with a lighter version of MDMA euphoria.
It is highly advised to use [[ harm reduction practices]] if using this substance as it has a very short history of use.


==History and culture==
==History and culture==
2-MMC, or 2-methylmethcathinone (orthomephedrone) is a psychoactive substance belonging to the synthetic cathinone group and is related to [[3-MMC]] and [[Mephedrone]]. It was first identified in Sweden in 2014.
It was first identified in Sweden in May 2014.<ref>{{cite web | url = https://www.emcdda.europa.eu/system/files/publications/1018/TDAN15001ENN.pdf | title = Europol 2014 Annual Report on the implementation of Council Decision 2005/387/JHA | publisher = European Monitoring Centre for Drugs and Drug Addiction | date = 10 May 2005 }}</ref>. Until recently, it had beeen an obscure substance, unclassified in many countries. Cases of its use were sporadic. However, since the Dutch ban on 3-MMC, the sale and use of 2-MMC became prevalent in the Netherlands.{{Citation needed}}


==Chemistry==
==Chemistry==
2-Methylmethcathinone (2-MMC) chemical name is 2-(methylamino)-1-phenylpropan-1-one and is a cathinone derivative, which is a synthetic form of phenylethylamines. 2-MMC has a cathinone which is substituted with a methyl group at the 2 position which makes it a structural isomer of Metaphedrone.
2-Methylmethcathinone's chemical name is 2-(methylamino)-1-phenylpropan-1-one and is a cathinone derivative, which is a synthetic form of phenylethylamines. 2-MMC has a cathinone which is substituted with a methyl group at the 2 position which makes it a structural isomer of Metaphedrone.


==Pharmacology==
==Pharmacology==
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==Subjective effects==
==Subjective effects==
{{EffectStub}}
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
{{effects/base
{{effects/base
|{{effects/physical|
|{{effects/physical|
If applicable, a brief paragraph summary of the substance's physical effects may be included here.
You may select physical effects to add below [[Subjective effect index#Physical effects|here]].
*'''[[Effect:Stimulation]]'''
*'''[[Effect:Pupil dilation]]'''
*'''[[Effect:Heartbeat increase]]'''


*'''[[Effect::Stimulation]]''' - Orthomephedrone is reported to be extremely energetic and stimulating in a fashion that is similar to that of [[MDMA]] or at higher dosages [[Amphetamine]] but stronger than that of [[modafinil]] or [[caffeine]]. It encourages physical activities like running, walking, or dancing which would otherwise be boring. The particular style of stimulation which orthomephedrone presents can be described as forced. This means that at higher dosages, it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes and vibrations become present, resulting in extreme shaking of the entire body, unsteadiness of the hands, and a general lack of motor control.
*'''[[Effect::Stamina enhancement]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Temperature regulation suppression]]'''
*'''[[Effect::Spontaneous physical sensations]]'''
**'''[[Effect::Physical euphoria]]'''
*'''[[Effect::Increased bodily temperature]]''' & *'''[[Effect::Decreased bodily temperature]]'''
*'''[[Effect::Increased perspiration]]'''
*'''[[Effect::Muscle twitching]]'''
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Increased blood pressure]]'''
**'''[[Effect::Increased heart rate]]''' - 2-MMC increases heart rate mildly to moderately compared to other stimulants.
*'''[[Effect::Vasoconstriction]]'''
*'''[[Effect::Dry mouth]]'''
**'''[[Effect::Dehydration]]'''
*'''[[Effect::Difficulty urinating]]''' - Higher doses of orthomephedrone can result in a burning-like sensation when urinating, or an overall difficulty peeing. An effect that is completely temporary and thought to be harmless.
*'''[[Effect::Mouth numbing]]''' - Particularly when insufflated, leaves a numbing sensation in one's throat.
*'''[[Effect::Vibrating vision]]''' - At overly high dosages or binging a person's eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing the vision to become blurry and temporarily out of focus. This is a condition known as [http://en.wikipedia.org/wiki/Nystagmus nystagmus].
*'''[[Effect::Frequent urination]]'''
*'''[[Effect::Tactile intensification]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Teeth grinding]]''' - This component can be considered to be less intense when compared with that of [[MDMA]].
*'''[[Effect::Restless leg syndrome]]'''
*'''[[Effect::Orgasm depression]]'''
*'''[[Effect::Temporary erectile dysfunction]]'''
*'''[[Effect::Seizure]]''' - This is a very rare effect but can likely happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, fatigued or when combining with other substances that lower the seizure threshold.
}}
}}
{{effects/visual|
{{effects/visual|
If applicable, a brief paragraph summary of the substance's visual effects may be included here.
*'''[[Effect::Double vision]]''' - At overly high dosages, often accompied by *'''[[Effect::Vibrating vision]]''' also known as [http://en.wikipedia.org/wiki/Nystagmus nystagmus].
}}
{{effects/cognitive|


You may select visual effects to add below [[Subjective effect index#Visual effects|here]].
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Anxiety suppression]]
*'''[[Effect::Amnesia]]''' - Heavy doses, and overdoses can cause partial or complete amnesia.
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Compulsive redosing]]'''
*'''[[Effect::Disinhibition]]
*'''[[Effect::Delusion]]'''
*'''[[Effect::Empathy, affection, and sociability enhancement]]
*'''[[Effect::Ego inflation]]
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Memory suppression]]''' - 2-MMC's positional isomer [[4-MMC]] has been shown to negatively impact short-term memory<ref>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045473</ref> and 2-MMC itself anecdotally is said to have immediate disruptive effects on memory.
*'''[[Effect::Motivation enhancement]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Delirium]]''' & '''[[Effect::Confusion]]''' - This effect typically only occurs with overly high doses, and is associated with temperature dysregulation, sleep deprivation and overheating, particularly when 2-MMC is taken in crowded, physically strenuous environments that leaves the user unable to cool off, rest, or rehydrate adequately.
*'''[[Effect::Psychosis]]'''
*'''[[Effect::Time distortion|Time compression]]''' - Strong feelings of time compression are commonly produced by 2-MMC and speed up the experience of time noticeably.
*'''[[Effect::Wakefulness]]'''


====Enhancements====
}}
*'''[[Effect::Visual acuity effect1]]'''
{{effects/aftereffects|
 
The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include:
====Distortions====
*'''[[Effect::Visual distortion effect1]]'''


====[[Effect::Geometry]]====
*'''[[Effect::Appetite suppression]]'''
If applicable, a brief paragraph summary describing the visual geometry produced by the substance may be included here.
*'''[[Effect::Cognitive fatigue]]'''
====Hallucinatory states====
*'''[[Effect::Delusion]]'''
If applicable, a brief summary of the substance's visual effects profile may be written here.
*'''[[Effect::Muscle twitching]]'''
*'''[[Effect::Motivation suppression]]'''
*'''[[Effect::Physical fatigue]]'''
*'''[[Effect::Dizziness]]'''
*'''[[Effect::Derealization]]''' & '''[[Effect::Depersonalization]]'''


*'''[[Effect::Hallucinatory states1]]'''
The "comedown" on 2-MMC is reported to be a smooth and clear gradual return to sobriety rather than a crash, which, by users is reported to be a lot less uncomfortable than traditional stimulant crash.


}}
}}
|{{effects/cognitive|
If applicable, a brief paragraph summary of the substance's cognitive effects may be included here.
You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]].
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Analysis enchancement]]'''
*'''[[Effect::Wakefulness]]'''
}}
}}


}}
===Experience reports===
===Experience reports===
There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
{{Experience reports|erowid_experience_substance_label=2-Methylmethcathinone}}
{{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}}
Additional experience reports can be found here:
* [https://www.erowid.org/experiences/subs/exp_SUBSTANCE.shtml Erowid Experience Vaults: SUBSTANCE] <!-- Check the link to see if it exists -->


==Toxicity and harm potential==
==Toxicity and harm potential==
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===Lethal dosage===
===Lethal dosage===
===Tolerance and addiction potential===
===Tolerance and addiction potential===
Like other [[cathinones]], 2-MMC remains a highly addictive substance
===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Stimulants|self=[[Substituted cathinone|cathinone]]s}}
*'''[[Cocaine]]''' - This combination may increase strain on the heart.


==Legal status==
==Legal status==
*'''Poland''': Illegal in Poland, the substance is not included in the list of groups of psychotropic substances, however, it falls under the group of psychotropic substances of group I-P as isomer of 3-MMC (metafedrone) and 4-MMC (mephedrone).
*'''Germany''': 2-MMC is controlled under the NpSG (''New Psychoactive Substances Act'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 19, 2019|language=de}}</ref> as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 19, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 19, 2019|language=de}}</ref>
*'''Poland''': Illegal in Poland, the substance is not included in the list of groups of psychotropic substances, however, it falls under the group of psychotropic substances of group I-P as isomer of 3-MMC (metaphedrone) and 4-MMC (mephedrone).


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[3-MMC]]
*[[3-MMC]]
*[[cathinones]]
*[[4-MMC]]
*[[Cathinones]]


==External links==
==External links==
(List along order below)
*[https://en.wikipedia.org/wiki/2-Methylmethcathinone 2-Methylmethcathinone (Wikipedia)]
* [https://en.wikipedia.org/wiki/2-Methylmethcathinone 2-Methylmethcathinone (Wikipedia)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=2479&name=2-Methylmethcathinone 2-Methylmethcathinone (Isomer Design)]
 
==Literature==
* APA formatted reference
 
Please see the [[citation formatting guide]] if you need assistance properly formatting citations.


==References==
==References==
<references />
<references />


[[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]]
[[Category:Psychoactive substance]]
[[Category:Stimulant]]
[[Category:Entactogen]]
[[Category:Cathinone]]
[[Category:Research chemical]]
[[Category:Proofread]][[Category:Approval]]
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