Talk:N-Methyl-Cyclazodone: Difference between revisions

(9 intermediate revisions by 2 users not shown)

Line 4:

'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. It is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.

'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.

Unlike [[cyclazodone]], N-methyl-cyclazodone has little to no history of use and only recently emerged as a study aid. Its non-clinical use has only found recent attention as a [[research chemical]] study aid or atypical [[antidepressant]]. It should be noted that the lack of pharmacological data and extremely limited history of human usage pose considerable concern regarding its long-term use as a substitute for prescription stimulants or [[antidepressants]]. Similar to [[methamphetamine]], this substance is reported to possess an usually long duration, it is therefore recommended to take one's dose in the morning and avoid redosing.

Line 22:

==Pharmacology==

N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has ~~minimal~~ sympathomimetic side effects ~~compared with typical dopaminergic central nervous system stimulants such as methylphenidate and [[Isomer|dextro]]-amphetamine.~~

N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has “minimal” sympathomimetic side effects, (although increased dopamine release is thought to cause an increse in more the release of norepinephrine thereby cussing sympathomimetic effects)

==Subjective effects==

@@ Line 4: / Line 4: @@
-'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. It is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.
+'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.
 Unlike [[cyclazodone]], N-methyl-cyclazodone has little to no history of use and only recently emerged as a study aid. Its non-clinical use has only found recent attention as a [[research chemical]] study aid or atypical [[antidepressant]]. It should be noted that the lack of pharmacological data and extremely limited history of human usage pose considerable concern regarding its long-term use as a substitute for prescription stimulants or [[antidepressants]]. Similar to [[methamphetamine]], this substance is reported to possess an usually long duration, it is therefore recommended to take one's dose in the morning and avoid redosing.
@@ Line 22: / Line 22: @@
 ==Pharmacology==
-N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has minimal sympathomimetic side effects compared with typical dopaminergic central nervous system stimulants such as methylphenidate and [[Isomer|dextro]]-amphetamine.
+N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has “minimal” sympathomimetic side effects, (although increased dopamine release is thought to cause an increse in more the release  of norepinephrine thereby cussing sympathomimetic effects)
 ==Subjective effects==