Talk:N-Methyl-Cyclazodone: Difference between revisions

{{SubstanceBox/N-Methyl-Cyclazodone}}

'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.

Unlike [[cyclazodone]], N-methyl-cyclazodone has little to no history of use and only recently emerged as a study aid. Its non-clinical use has only found recent attention as a [[research chemical]] study aid or atypical [[antidepressant]]. It should be noted that the lack of pharmacological data and extremely limited history of human usage pose considerable concern regarding its long-term use as a substitute for prescription stimulants or [[antidepressants]]. Similar to [[methamphetamine]], this substance is reported to possess an usually long duration, it is therefore recommended to take one's dose in the morning and avoid redosing.

N-methyl-cyclazodone has no documented history of recreational human usage before it appeared on the online research chemical market in 2017. Based on related compounds, it is speculated that it likely possesses hepatotoxic and other not-yet-known toxic properties.  

N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has “minimal” sympathomimetic side effects, (although increased dopamine release is thought to cause an increse in more the release  of norepinephrine thereby cussing sympathomimetic effects)

*'''[[Effect::Stimulation]]''' - N-methyl-cyclazodone is reported to be somewhat stimulating though soft in a fashion that is generally weaker than [[methamphetamine]], but stronger than [[modafinil]], [[caffeine]], and [[methylphenidate]]. It can encourage physical activities such as dancing, socializing, running, or cleaning. The particular style of stimulation which amphetamine produces can be described as forced.

*'''[[Effect::Anxiety suppression]]''' - The anxiolytic effects of N-methyl-cyclazodone are generally weaker than those of [[cyclazodone]].

*'''[[Effect::Cognitive euphoria]]''' - This effect is dose dependent; a low dose will tend to produce only that of a slight mood lift and moderate to high doses are typically reported to be on par with that of [[amphetamine]], though less than that of [[methamphetamine]] and [[3-FMA]]. It is the strongest when used infrequently at moderate doses, and binges often result in a loss of this effect.

*'''[[Effect::Compulsive redosing]]''' - This effect is generally much less prominent than with [[cyclazodone]] mostly due its long duration.

*'''[[Effect::Focus enhancement]]''' - N-methyl-cyclazodone is reported to produce strong focus-enhancing effects that rival common ADHD stimulants such as [[amphetamine]] and [[methylphenidate]].

*'''[[Effect::Increased music appreciation]]''' - This effect is usually weaker than with [[cyclazodone]].

*'''[[Effect::Wakefulness]]''' - This effect is reported to be similar in duration to [[methamphetamine]], with some users reporting an inability to sleep. It is advised to take one's dose at the start of the day to minimize this effect.

The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. The "comedown" of N-methyl-cyclazodone is generally weaker and smoother and that of [[cyclazodone]], with some users reporting no after effects at all. Its effects commonly include: