Talk:N-Methyl-Cyclazodone: Difference between revisions

(13 intermediate revisions by 3 users not shown)

Line 1:

{{decree|type=notice|message=This article is in the 'Talk' namespace because it is an unfinished draft. This section is used to host drafts for unpublished articles as well as discussions for published ones. If you'd like to use this area to discuss this draft, please do so in the 'Discussion' section at the very bottom of the page. This notice will be removed once this draft has been approved for publication by an administrator.}}

{{headerpanel|{{approval}}{{stub}}}}

Line 5:

Line 4:

'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. It is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.

'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.

Unlike [[cyclazodone]], N-methyl-cyclazodone has little to no history of use and only recently emerged as a study aid. Its non-clinical use has only found recent attention as a [[research chemical]] study aid or atypical [[antidepressant]]. It should be noted that the lack of pharmacological data and extremely limited history of human usage pose considerable concern regarding its long-term use as a substitute for prescription stimulants or [[antidepressants]]. Similar to [[methamphetamine]], this substance is reported to possess an usually long duration, it is therefore recommended to take one's dose in the morning and avoid redosing.

Line 23:

Line 22:

==Pharmacology==

N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has ~~minimal~~ sympathomimetic side effects ~~compared with typical dopaminergic central nervous system stimulants such as methylphenidate and [[Isomer|dextro]]-amphetamine.~~

N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has “minimal” sympathomimetic side effects, (although increased dopamine release is thought to cause an increse in more the release of norepinephrine thereby cussing sympathomimetic effects)

==Subjective effects==

@@ Line 1: / Line 1: @@
-{{decree|type=notice|message=This article is in the 'Talk' namespace because it is an unfinished draft. This section is used to host drafts for unpublished articles as well as discussions for published ones. If you'd like to use this area to discuss this draft, please do so in the 'Discussion' section at the very bottom of the page. This notice will be removed once this draft has been approved for publication by an administrator.}}
 {{headerpanel|{{approval}}{{stub}}}}
 {{SummarySheet}}
@@ Line 5: / Line 4: @@
-'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. It is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.
+'''N-Cyclopropyl-N-Methylpemoline''' (also known as '''N-Methyl-Cyclazodone''' or '''NMC''') is a novel [[psychoactive class::stimulant]] substance of the [[chemical class::4-oxazolidinone]] class. is structurally related to [[thozalinone]] and [[cyclazodone]]. Similar to [[amphetamine]], the addition of the methyl group on [[cyclazodone]] is thought to increase its potency and duration. The mechanism of action involves promoting the release of [[dopamine]], [[norepinephrine]], and [[serotonin]] in the brain.
 Unlike [[cyclazodone]], N-methyl-cyclazodone has little to no history of use and only recently emerged as a study aid. Its non-clinical use has only found recent attention as a [[research chemical]] study aid or atypical [[antidepressant]]. It should be noted that the lack of pharmacological data and extremely limited history of human usage pose considerable concern regarding its long-term use as a substitute for prescription stimulants or [[antidepressants]]. Similar to [[methamphetamine]], this substance is reported to possess an usually long duration, it is therefore recommended to take one's dose in the morning and avoid redosing.
@@ Line 23: / Line 22: @@
 ==Pharmacology==
-N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has minimal sympathomimetic side effects compared with typical dopaminergic central nervous system stimulants such as methylphenidate and [[Isomer|dextro]]-amphetamine.
+N-Methyl-Cyclazodone is an approximately 4x - 6x more potent N,N-methylcyclopropyl derivative of [[pemoline]]. Pemoline is considered to be [[dopamine|dopaminergic]], but its precise method of action has not been fully determined.<ref>"Cylert (Pemoline)" (PDF). FDA. December 2002.</ref> Pemoline has minimal affinity for [[noradrenaline]] receptors and thus has “minimal” sympathomimetic side effects, (although increased dopamine release is thought to cause an increse in more the release  of norepinephrine thereby cussing sympathomimetic effects)
 ==Subjective effects==