Talk:Eugeroic: Difference between revisions
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'''Eugeroics''' (originally, "eugrégorique" or "eugregoric"),<ref>Milgram, Norton W.; Callahan, Heather; Siwak, Christina (2006). "Adrafinil: A Novel Vigilance Promoting Agent". CNS Drug Reviews. 5 (3): 193–212. doi:10.1111/j.1527-3458.1999.tb00100.x.</ref> also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and alertness.<ref name="modaFDA">[https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020717s037s038lbl.pdf "Provigil: Prescribing information" (PDF)]. United States Food and Drug Administration. Cephalon, Inc. January 2015. Retrieved 16 August 2015.</ref><ref name="armodaFDA">[https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021875s021lbledt.pdf "Nuvigil: Prescribing information" (PDF)]. United States Food and Drug Administration. Cephalon, Inc. April 2015. Retrieved 16 August 2015.</ref> They are used medically for the treatment of certain sleeping disorders, such as excessive daytime sleepiness and narcolepsy.<ref name="modaFDA" /><ref name="armodaFDA" /> Unlike traditional stimulants, they generally have a low addictive potential.<ref name="modaFDA" /><ref name="armodaFDA" /> | |||
The prototypical and most widely known eugeroic is [[modafinil]]. Other substances in the class include [[armodafinil]], its [[enantiopure]] formulation, and [[adrafinil]], a modafinil [[prodrug]]. Modafinil and armodafinil have been found to act as selective, weak, atypical dopamine reuptake inhibitors.<ref name="modaFDA" /><ref name="armodaFDA" /> | |||
==Subjective effects== | |||
{{Preamble/SubjectiveEffects}} | |||
These effects are listed and defined in detail within their own dedicated articles below: | |||
*'''[[Wakefulness]]''' | |||
*'''[[Stimulation]]''' | |||
*'''[[Thought acceleration]]''' | |||
Secondary effects include: | |||
*'''[[Focus enhancement]]''' | |||
*'''[[Cognitive euphoria]]''' | |||
*'''[[Memory enhancement]]''' | |||
*'''[[Analysis enhancement]]''' | |||
*'''[[Increased music appreciation]]''' | |||
*'''[[Ego inflation]]''' | |||
*'''[[Time distortion]]''' - This can be described as the experience of time speeding up and passing much quicker than it usually would when sober. | |||
==Examples== | |||
* [[Modafinil]] | |||
* [[Armodafinil]] | |||
* [[Adrafinil]] | |||
* [[Lauflumide]] | |||
==See also== | |||
* [[Stimulants]] | |||
==Literature== | |||
* Engber TM, Koury EJ, Dennis SA, Miller MS, Contreras PC, Bhat RV (January 1998). "Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil". Neurosci. Lett. 241 (2-3): 95–8. PMID 9507929. https://doi.org/10.1016/s0304-3940(97)00962-2. | |||
* Darwish, M.; Kirby, M.; Hellriegel, E. T.; Robertson Jr, P. (2009). "Armodafinil and Modafinil Have Substantially Different Pharmacokinetic Profiles Despite Having the Same Terminal Half-Lives". Clinical Drug Investigation. 29 (9): 613–623. PMID 19663523. https://doi.org/10.2165/11315280-000000000-00000. | |||
* Milgram, Norton W.; Callahan, Heather; Siwak, Christina (2006). "Adrafinil: A Novel Vigilance Promoting Agent". CNS Drug Reviews. 5 (3): 193–212. https://doi.org/10.1111/j.1527-3458.1999.tb00100.x. | |||
==External links== | |||
*[[wikipedia:Eugeroic|Eugeroic (Wikipedia)]] | |||
==References== | |||
<references /> | |||
==Notes== | |||
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A wakefulness-promoting agent (or wakefulness-promoting drug), also known as a eugeroic (originally "eugrégorique" or "eugregoric"), is a type of drug which specifically improves wakefulness and alertness. | A wakefulness-promoting agent (or wakefulness-promoting drug), also known as a eugeroic (originally "eugrégorique" or "eugregoric"), is a type of drug which specifically improves wakefulness and alertness. | ||
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The prototypical eugeroic is modafinil, and others. | The prototypical eugeroic is modafinil, and others. | ||
[[Category:Approval]] |