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Talk:Amisulpride: Difference between revisions
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==Chemistry== | ==Chemistry== | ||
{{chemistry}} | {{chemistry}} | ||
Amisulpride is the 4-position amino substitution of [[sulpiride]] which in turn is based on a [[chemical class::benzamide]] core. | |||
==Pharmacology== | ==Pharmacology== | ||
Amisulpride primarily works by antagonising D<sub>2</sub> and D<sub>3</sub> [[dopamine]] receptors aswell as the 5-HT<sub>7</sub>, 5-HT<sub>2A</sub> and 5-HT<sub>2B</sub> [[serotonin]] receptors. | |||
It is also known to act as a [[GHB receptor]] agonist and Mu- Delta- Kappa-[[opioid]] agonist<ref>Rehni AK, Singh TG, Chand P: Amisulpride-induced seizurogenic effect: a potential role of opioid receptor-linked transduction systems. Basic Clin Pharmacol Toxicol. 2011 May;108(5):310-7. doi: 10.1111/j.1742-7843.2010.00655.x. Epub 2010 Dec 22. (PubMed ID 21176108)</ref> | |||
==Subjective effects== | ==Subjective effects== | ||
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*'''[[Effect::Thought deceleration]]''' | *'''[[Effect::Thought deceleration]]''' | ||
*'''[[Effect::Thought acceleration]]''' | *'''[[Effect::Thought acceleration]]''' contradictory side effect | ||
*'''[[Effect::Dream potentiation]]''' | *'''[[Effect::Dream potentiation]]''' | ||
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*[https://isomerdesign.com/PiHKAL/explore.php?id=9407 Amisulpride (Isomer Design)] | *[https://isomerdesign.com/PiHKAL/explore.php?id=9407 Amisulpride (Isomer Design)] | ||
*[https://go.drugbank.com/drugs/DB06288 Amisulpride (DrugBank)] | *[https://go.drugbank.com/drugs/DB06288 Amisulpride (DrugBank)] | ||
*[https://www.drugs.com/mtm/amisulpride.html#dosage Amisulpride (Drugs.com)] | |||
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==References== | ==References== | ||
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[[Category:Antipsychotic]] | [[Category:Antipsychotic]] | ||
[[Category:Atypical Neuroleptic]] | [[Category:Atypical Neuroleptic]] | ||
[[Category:Opioid]] | |||
[[Category:Benzamide]] | |||
[[Category:Psychoactive substance]] | [[Category:Psychoactive substance]] | ||
[[Category:Proofread]] | [[Category:Proofread]] | ||
[[Category:Approval]] | [[Category:Approval]] | ||