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Talk:5-MeO-aMT: Difference between revisions
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{{SummarySheet}} | {{SummarySheet}} | ||
{{SubstanceBox/5-MeO-aMT}} | {{SubstanceBox/5-MeO-aMT}} | ||
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==Chemistry== | ==Chemistry== | ||
5-MeO-aMT, or 5-methoxy-α-methyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 5-MeO-aMT is substituted at the alpha carbon R<sub>α</sub> of its tryptamine backbone with a methyl group. | 5-MeO-aMT, or 5-methoxy-α-methyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. Like [[aMT]], 5-MeO-aMT is substituted at the alpha carbon R<sub>α</sub> of its tryptamine backbone with a methyl group, but differs from aMT by a methoxy group added to the R<sub>5</sub> position. | ||
A comparison of the R- and S-isomers found that the S-isomer is "clearly three or four times more potent" than the R-isomer. The S-isomer is the d- or dextrorotary one and has been noted to possess the absolute configuration of the active member of the isomer pairs of [[amphetamine]], [[methamphetamine]], and [[MDMA]].<ref name="tihkalweb" /> | A comparison of the R- and S-isomers found that the S-isomer is "clearly three or four times more potent" than the R-isomer. The S-isomer is the d- or dextrorotary one and has been noted to possess the absolute configuration of the active member of the isomer pairs of [[amphetamine]], [[methamphetamine]], and [[MDMA]].<ref name="tihkalweb" /> | ||
==Pharmacology== | ==Pharmacology== | ||
{{pharmacology}} | |||
{{Further|Serotonergic psychedelic}} | {{Further|Serotonergic psychedelic}} | ||
5-MeO-aMT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. | 5-MeO-aMT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive. | ||
5-MeO-AMT also inhibits [[monoamines]] ([[dopamine]], [[serotonin]] and [[norepinephrine]]) reuptake and stimulates their release.<ref>The Effects of Non-Medically Used Psychoactive Drugs on Monoamine Neurotransmission in Rat Brain | https://pubmed.ncbi.nlm.nih.gov/17223101</ref> | |||
==Subjective effects== | ==Subjective effects== | ||
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{{#ask:[[Category:Experience]][[Category:5-MeO-aMT]]|format=ul|Columns=1}} | {{#ask:[[Category:Experience]][[Category:5-MeO-aMT]]|format=ul|Columns=1}} | ||
Additional experience reports can be found here: | Additional experience reports can be found here: | ||
* [https://www.erowid.org/experiences/subs/ | *[https://www.erowid.org/experiences/subs/exp_5MeOAMT.shtml Erowid Experience Vaults: 5-MeO-aMT] | ||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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== | ==Legal status== | ||
{{legalStub}} | {{legalStub}} | ||
*'''United States''': 5-MeO-AMT is unscheduled in the United States. It is possible that it could be considered an analog (of AMT), in which case, sales for human consumption or possession with the intent to ingest could be prosecuted under the Federal Analogue Act. The DEA and the US Department of Justice consider 5-MeO-AMT a controlled substance analogue, making it a Schedule I substance when intended for human consumption.<ref>{{Citation | year=2022 | title=5-MeO-AMT Fast Facts | publisher=US DOJ | url=https://www.justice.gov/archive/ndic/pubs9/9576/index.htm}}</ref> | |||
==See also== | ==See also== | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/5-MeO-aMT 5-MeO-aMT (Wikipedia)] | *[https://en.wikipedia.org/wiki/5-MeO-aMT 5-MeO-aMT (Wikipedia)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?id=5005 5-MeO-aMT (Isomer Design)] | *[https://www.erowid.org/chemicals/5meo_amt/ 5-MeO-aMT (Erowid Vault)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?id=5005 5-MeO-aMT (TiHKAL / Isomer Design)] | |||
===Discussion=== | |||
*[https://www.bluelight.org/xf/threads/61754 The Big & Dandy 5-MeO-AMT Thread (Bluelight)] | |||
==References== | ==References== | ||
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[[Category:Entactogen]] | [[Category:Entactogen]] | ||
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