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{{SummarySheet}}
{{SubstanceBox/2C-B-FLY}}
{{SubstanceBox/2C-B-FLY}}
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| ''[[2C-B-FLY/Summary|Summary sheet: 2C-B-FLY]]''
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'''2C-B-FLY''' is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] and [[chemical class::benzodihydrodifuran]] chemical classes that produces a highly dose-sensitive spectrum of [[psychedelic]] and moderate [[entactogenic]] effects which typically last 6–8 hours (or up to 12 hours in larger doses) when [[Route of administration|administered]]. Subjectively, the effects it produces has been compared to those of [[2C-B]], [[mescaline]] and [[MDA]].


2C-B-FLY is a derivative of the [[2C-x]] family, specifically [[2C-B]]. It was first synthesized by Aaron P. Monte in 1996.<ref>https://erowid.org/chemicals/2cb_fly/2cb_fly_info1.shtml</ref><ref>http://www.sciencedirect.com/topics/page/2C-B-FLY</ref>. It briefly gained popularity around 2005 before becoming significantly less common after two deaths occurred in October 2009 after the ingestion of a substance that was labeled and sold as 2C-B-FLY actually turned out to be [[Bromo-DragonFLY]],<ref>Information on Reported Deaths Related to 2C-B-FLY | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml</ref> which is an order of magnitude more potent. This led to its immediate withdrawal until around 2016, where it began to be produced and sold again.
'''2C-B-FLY''' is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] and [[chemical class::benzodihydrodifuran]] classes that produces an array of [[psychedelic]] and [[entactogenic]] effects when [[Route of administration|administered]]. Reports have characterized its effects profile as possessing features of [[2C-B]], [[mescaline]] and [[MDA]], with a duration of 6–8 hours (or up to 12 hours in larger doses).
 
2C-B-FLY is a derivative of the [[2C-x]] family of psychedelic [[phenethylamines]], specifically [[2C-B]], of which it significantly differs from in terms of its potency, metabolism, and potential toxicity. It was first synthesized by Aaron P. Monte in 1996.<ref>{{Citation | title=Erowid 2C-B-Fly Vaults : 2C-B-FLY | url=https://erowid.org/chemicals/2cb_fly/2cb_fly_info1.shtml}}</ref>
 
Around 2005, 2C-B-FLY appeared and gained some popularity in the online [[research chemicals]] market before largely disappearing in October 2009, when a batch of [[Bromo-DragonFLY]] was accidentally mislabeled as 2C-B-FLY (Bromo-DragonFLY is dosed in micrograms, where 2C-B-FLY is dosed in milligrams) led to two deaths as a result of taking overdoses of Bromo-DragonFLY meant to be effective doses for 2C-B-FLY.<ref>{{Citation | title=Erowid 2C-B-Fly Vault: Death Reports 2009 | url=https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml}}</ref> This event led to its immediate withdrawal until around 2016, when it resurfaced on the market again.
 
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B-FLY, and it has little history of human usage. It has no documented history of being sold on the streets and is commercially distributed through online [[research chemical]] vendors.
 
Due to its high potency and sensitive dose-response, many reports also indicate that the effects of this substance should not be seen as a simple substitute for [[2C-B]]. It is highly advised to approach this potent, long-lasting, and unpredictable hallucinogenic substance with the proper amount of precaution and harm reduction practices if choosing to use it.
 
==History and culture==
{{historyStub}}
In a 2007 [[MAPS]] newsletter interview, [[Ann Shulgin]] revealed that 2C-B-FLY as one of her favorite [[psychedelic]] substances while also acknowledging the high variability in responses it seemed to display.<ref>{{cite journal | journal=MAPS | title=An Interview with Ann Shulgin on Psychedelics and Self-Discovery | volume=17 | issue=2 | pages=23–24 | date= 2007 | url=https://maps.org/news-letters/v17n2/v17n2_annshulgin-23.pdf}}</ref>


Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B-FLY, and it has little history of human usage. It has no documented history of being sold in the streets and is commercially distributed through online [[research chemical]] vendors. Due to its high potency and sensitive dose-response, many reports also indicate that the effects of this substance should not be seen as a simple substitute for [[2C-B]]. It is highly advised to approach this potent, long-lasting, and unpredictable hallucinogenic substance with the proper amount of precaution and harm reduction practices if one chooses to use it.
{{quote3|text=I said often, too often, that something called 2CB Fly ''(sic)'' was absolutely great for me. To me, it’s the loveliest thing, especially for eroticism. But I found out that it’s not interesting to anybody else. I realized that having said that, I was putting things in motion. The Internet was full of 2CB Fly ''(sic)'', and people were asking about it and I thought “uh-oh.” It turned out that it’s a disappointment to most other people.|author=Ann Shulgin}}


==Chemistry==
==Chemistry==
2C-B-FLY is a substituted molecule of the [[phenethylamine]] and [[dihydrobenzofuran]] chemical classes. 2C-B-FLY features a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain and contains a bromine atom attached to carbon R<sub>4</sub> of the phenyl ring. 2C-B-FLY is an atypical psychedelic phenethylamine which is closely analogous to [[2C-B]]; it is the dihydrofuran analog to 2C-B, where it incorporates the methoxy groups bound to R<sub>2</sub> and R<sub>5</sub> of 2C-B into five member dihydrofuran rings fused to the central benzene ring.
2C-B-FLY is a substituted molecule of the [[Substituted Phenethylamine|phenethylamine]] and [[dihydrobenzofuran]] chemical classes. 2C-B-FLY features a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain and contains a bromine atom attached to carbon R<sub>4</sub> of the phenyl ring.  
 
It is an atypical psychedelic phenethylamine which is closely analogous to [[2C-B]]; it is the dihydrofuran analog to 2C-B, where it incorporates the methoxy groups bound to R<sub>2</sub> and R<sub>5</sub> of 2C-B into five-member dihydrofuran rings fused to the central benzene ring.


2C-B-FLY belongs to a group of phenethylamine derivatives referred to as the FLY compounds, named for their insect-like appearance of two “wing-like” tetrahydrofuran rings fused on the opposite sides of the central benzene ring. The incorporation of the two methoxy groups into the 5 member rings fixes them into the optimum position for binding to the receptors they interact with resulting in an increase in potency compared to the compound's non-rigid counterpart 2C-B.<ref>http://heffter.org/docs/hrireview/01/chapter5.pdf</ref>
2C-B-FLY belongs to a group of phenethylamine derivatives referred to as the FLY compounds, named for their insect-like appearance of two “wing-like” tetrahydrofuran rings fused on the opposite sides of the central benzene ring. The incorporation of the two methoxy groups into the 5 member rings fixes them into the optimum position for binding to the receptors they interact with resulting in an increase in potency compared to the compound's non-rigid counterpart [[2C-B]].


==Pharmacology==
==Pharmacology==
{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
Little is known about how the totality of its effects are produced, 2C-B-FLY's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]].
2C-B-FLY is a psychedelic phenethylamine, and is the dihydrodifuran analog of 2C-B.
 
Little is known about how the totality of its effects are produced, 2C-B-FLY's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation.


However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain an object of scientific elucidation.
==Subjective effects==
==Subjective effects==
{{Preamble/SubjectiveEffects}}
In comparison to [[2C-B]], this compound presents a significantly more pronounced body high/load, stronger visual effects, more complex [[geometry]] and more in-depth [[internal hallucinations]] which are comparable to [[mescaline]], [[2C-E]] or [[MDA]] at higher doses. Lower doses, however, are associated with more [[entactogenic]] as opposed to classical psychedelic effects.


In comparison to [[2C-B]], this compound presents a significantly more pronounced body high/load, stronger visual effects, more complex [[geometry]] and more in-depth [[internal hallucinations]] which are comparable to [[mescaline]], [[2C-E]] or [[MDA]] at higher doses. Lower doses, however, are associated with more [[entactogenic]] as opposed to classical psychedelic effects.
{{Preamble/SubjectiveEffects}}
 
===Physical effects===
{{effects/base
The physical effects of 2C-B-FLY are comparable to that of traditional [[phenethylamines]] such as [[2C-E]], [[mescaline]] and [[2C-T-7]].
 
|{{effects/physical|
The physical effects of 2C-B-FLY are comparable to that of traditional [[Substituted Phenethylamine|phenethylamines]] such as [[2C-E]], [[mescaline]] and [[2C-T-7]] along with more pronounced side effects.


Many people have reported general gastrointestinal disturbances using compound which include [[diarrhoea]], [[nausea]], moderate to severe [[stomach bloating]] and general gassiness at [[moderate]] to [[heavy]] [[dosages]]. These effects are comparable to that of [[5-MeO-MiPT]], [[2C-T-7]] and other compounds with highly suspected [[MAO]]-altering properties. This suggests that 2C-B-FLY may potentially have such MAO-altering properties of its own, although this has yet to be confirmed.
There have been reports gastrointestinal disturbances following the use of this compound which include [[diarrhea]], [[nausea]], moderate to severe [[stomach bloating]] and general gassiness at [[moderate]] to [[heavy]] doses. These effects are comparable to that of [[5-MeO-MiPT]], [[2C-T-7]] and other compounds with suspected [[MAO]]-altering properties. This suggests that 2C-B-FLY may potentially have such MAO-altering properties of its own, which may make it dangerous to combine with certain substances.  


*'''[[Effect::Stimulation]]''' and '''[[Effect::Sedation]]''' - At [[light]] [[dosage]]s, this compound is generally stimulating but in a gentle, non-forceful manner similar to that of [[2C-B]] or [[mescaline]]. At higher dosages one may find the amount of stimulation to increase to an uncomfortable level with undertones of sedation or lethargy in a manner similar to that of [[2C-C]] or [[2C-T-7]].
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 2C-B-FLY can be described as a pleasurable, warm, soft, all-encompassing and mild tingling sensation. This maintains a consistent presence that steadily rises with the [[onset]] and hits its limit once the [[peak]] has been reached. It is comparable to that of a milder [[mescaline]], [[2C-B]] or [[2C-E]] experience.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 2C-B-FLY can be described as a pleasurable, warm, soft, all-encompassing and mild tingling sensation. This maintains a consistent presence that steadily rises with the [[onset]] and hits its limit once the [[peak]] has been reached. It is comparable to that of a milder [[mescaline]], [[2C-B]] or [[2C-E]] experience.
**'''[[Effect::Physical euphoria]]'''
**'''[[Effect::Physical euphoria]]'''
*'''[[Effect::Spontaneous tactile sensations]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Stimulation]]''' and '''[[Effect::Sedation]]''' - At [[light]] [[dosage]]s, this compound is generally stimulating but in a gentle, non-forceful manner similar to that of [[2C-B]] or [[mescaline]]. However, at [[heavy|heavier]] dosages one may find the amount of stimulation to increase to uncomfortable degrees if not feeling significantly sedated in a manner similar to that of [[2C-C]] or one of the many compounds in the [[2C-T]] series, most prominently [[2C-T-7]].
*'''[[Effect::Temperature regulation suppression]]''' - Compared to 2C-B, this effect is far more pronounced and unpredictable in its manifestation. Small increases in the dose may result in large changes in this effect.
*'''[[Effect::Temperature regulation suppression]]'''
**'''[[Effect::Increased bodily temperature]]'''
**'''[[Effect::Increased temperature]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Bodily pressures]]'''
*'''[[Effect::Bodily pressures]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Headaches]]'''
*'''[[Effect::Headaches]]''' - This effect is more commonly reported than 2C-B or other traditional phenethylamines.
*'''[[Effect::Muscle cramps]]'''
*'''[[Effect::Muscle cramps]]'''
*'''[[Effect::Stomach bloating]]'''
*'''[[Effect::Stomach bloating]]'''
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*'''[[Effect::Diarrhea]]'''  
*'''[[Effect::Diarrhea]]'''  
*'''[[Effect::Dehydration]]'''  
*'''[[Effect::Dehydration]]'''  
*'''[[Effect::Difficulty urinating]]'''
*'''[[Effect::Excessive yawning]]'''  
*'''[[Effect::Excessive yawning]]'''  
*'''[[Effect::Watery eyes]]'''  
*'''[[Effect::Watery eyes]]'''  
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*'''[[Effect::Teeth grinding]]'''
*'''[[Effect::Teeth grinding]]'''


===Cognitive effects===
}}
It is worth noting that despite the potential cognitive effects of 2C-B-FLY, it tends to maintain a level of relatively normal and sober thought structure regardless of the subjective visual, physical and cognitive accompanying effects intensity. This leaves the user in control in a manner which would not be possible on many compounds such as [[4-AcO-DMT]], [[psilocin]] or [[LSD]] due to their accompanying [[confusion]] and [[delusion]]s.
{{effects/visual|
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Disinhibition]]'''
*'''[[Effect::Emotionality enhancement]]'''
*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This compound presents entactogenic effects on a level which is less intense than that of [[2C-B]] or [[MDMA]] but similar in quality to that of [[mescaline]] or [[2C-E]].
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Wakefulness]]'''
 
===Visual effects===
====Enhancements====
====Enhancements====
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
Line 92: Line 89:


*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
===Auditory effects===
 
}}
|{{effects/cognitive|
 
2C-B-FLY tends to maintain a level of relatively normal and sober thought structure regardless of the subjective visual, physical and cognitive accompanying effects intensity. This leaves the user in control in a manner which would not be possible on many compounds such as [[4-AcO-DMT]] or [[LSD]] due to their accompanying [[confusion]] and [[delusions]].
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Disinhibition]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This compound presents entactogenic effects on a level which is less intense than that of [[2C-B]] or [[MDMA]] but similar in quality to that of [[mescaline]] or [[2C-E]].
*'''[[Effect::Increased libido]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Wakefulness]]'''
 
}}
{{effects/auditory|
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''


===After effects===
}}
The effects which occur during the [[offset]] of this compound are comparable to that of a mild [[stimulant]] or [[entactogen]]. The experience generally feels negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and may occur because of [[neurotransmitter]] depletion or receptor downregulation. Its effects commonly include:
{{effects/aftereffects|
 
The effects which occur during the [[offset]] of this compound are comparable to that of a mild [[stimulant]] or [[entactogen]]. The experience generally feels negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and may occur due to the physically fatiguing aspects of this substance. Its effects commonly include:


*'''[[Effect::Headaches]]'''
*'''[[Effect::Headaches]]'''
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*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Thought deceleration]]'''


}}
}}
===Experience reports===
===Experience reports===
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
* [https://www.erowid.org/experiences/subs/exp_2CBFly.shtml Erowid Experience Vaults: 2C-B-FLY]
 
*[https://www.erowid.org/experiences/subs/exp_2CBFly.shtml Erowid Experience Vaults: 2C-B-FLY]


==Toxicity and harm potential==
==Toxicity and harm potential==
{{toxicity}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 2C-B-FLY do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-B-FLY is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 2C-B-FLY suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
The toxicity and long-term health effects of recreational 2C-B-FLY do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-B-FLY is a [[research chemical]] with a very limited history of human usage.  
 
Anecdotal evidence from people within the community who have tried 2C-B-FLY suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.


It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
===Tolerance and addiction potential===
===Tolerance and addiction potential===
2C-B-FLY is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  
2C-B-FLY is [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with use. It is most often self-regulating.  


Tolerance to the effects of 2C-B-FLY are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 2C-B-FLY presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-B-FLY all psychedelics will have a reduced effect.
Tolerance to the effects of 2C-B-FLY is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 2C-B-FLY presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-B-FLY all psychedelics will have a reduced effect.


===Dangerous interactions===
===Dangerous interactions===
{{Template:DangerousInteractions/Intro}}
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Psychedelics}}


If 2C-B-FLY does have suspected MAO-altering effects, this could indicate that 2C-B-FLY is more likely to induce [[serotonin syndrome]] or general [[monoamine]] overload (especially at high dosages) than other [[serotonergic psychedelic]]s.<ref>Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109</ref> This may make it dangerous to combine it with [[MAOI]]s, [[stimulant]]s and certain substances which modulate synaptic concentrations of neurotransmitters such as [[serotonin]], [[dopamine]] and [[norepinephrine]] through unknown mechanisms. These substances include but are not limited to:
If 2C-B-FLY does have suspected MAO-altering effects, this could indicate that 2C-B-FLY is more likely to induce [[serotonin syndrome]] or general [[monoamine]] overload (especially at high dosages) than other [[serotonergic psychedelic]]s.<ref>{{cite journal | vauthors=((Gallardo-Godoy, A.)), ((Fierro, A.)), ((McLean, T. H.)), ((Castillo, M.)), ((Cassels, B. K.)), ((Reyes-Parada, M.)), ((Nichols, D. E.)) | journal=Journal of Medicinal Chemistry | title=Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling | volume=48 | issue=7 | pages=2407–2419 | date=1 April 2005 | url=https://pubs.acs.org/doi/10.1021/jm0493109 | issn=0022-2623 | doi=10.1021/jm0493109}}</ref> This may make it dangerous to combine it with [[MAOI]]s, [[stimulant]]s and certain substances which modulate synaptic concentrations of neurotransmitters such as [[serotonin]], [[dopamine]] and [[norepinephrine]] through unknown mechanisms. These substances include but are not limited to:
{|
{|
|-
|-
|  
|
*'''[[5-MeO-MiPT]]'''
*'''[[5-MeO-MiPT]]'''
*'''[[2-C-T-7]]'''
*'''[[2-C-T-7]]'''
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*'''[[Cocaine]]'''
*'''[[Cocaine]]'''
*'''[[Ethylphenidate]]'''
*'''[[Ethylphenidate]]'''
*'''[[Dehydroxyfluorafinil]]'''
*'''[[N-Methylbisfluoromodafinil]]'''
||
||
*'''[[Isopropylphenidate]]'''
*'''[[Isopropylphenidate]]'''
Line 155: Line 181:
*'''[[NM-2-AI]]'''
*'''[[NM-2-AI]]'''
*'''[[Noopept]]'''
*'''[[Noopept]]'''
*'''[[SSRIs]]
*'''[[SSRIs]]'''
*'''[[SNRIs]]
*'''[[SNRIs]]'''
|}
|}


==Legality==
==Legal status==
{{legalStub}}
{{legalStub}}
*'''United States''' - 2C-B-FLY is unscheduled and uncontrolled in the United States. However, it may fall under the scope of the Federal Analog Act if it is intended for human consumption given its similarity to 2C-B.
 
*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
*'''Austria''': 2C-B-FLY is illegal to possess, produce and sell under the NPSG. (Neue-Psychoaktive-Substanzen-Gesetz Österreich).{{citation needed}}
*'''Canada:''' 2C-B-FLY would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.<ref>Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28</ref>
*'''Canada''': 2C-B-FLY would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.<ref>Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28</ref>
*'''Germany''': 2C-B-FLY is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 11, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref>
*'''Italy''': 2C-B-FLY is a schedule I substance and is illegal to possess, produce, sell and buy.{{citation needed}}
*'''Poland''': 2C-B-FLY is unscheduled in Poland. However, it would be considered in Group II-P drug as it is a derivative of 2,5-dimethoxyphenethylamine.<ref>{{cite web|url=https://sip.lex.pl/akty-prawne/dzu-dziennik-ustaw/wykaz-substancji-psychotropowych-srodkow-odurzajacych-oraz-nowych-18747849|title=Wykaz substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych|access-date=5 June, 2024|language=pl}}</ref>
*'''Sweden''': As of April 2018, 2C-B-FLY is illegal to possess, sell, buy and use under Swedish law.<ref>{{Citation | title=Nyhetsarkiv — Folkhälsomyndigheten | url=https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/}}</ref>
*'''Switzerland''': It is unclear whether 2C-B-FLY is in the scope of a substituted phenethylamine under Verzeichnis E point 130, since it is not an "alkyl, alkoxy, alkylenedioxy or halide derivative of phenethylamine", while additionally containing further univalent substituents, according to the scope. Although it could theoretically be considered an alkoxy derivative, it would still miss one hydrogen atom on the alkyl part of the alkoxy substituent. It is also unclear if it can be considered a true ether analog of an ether analog of 2C-B which would make it controlled under Buchstabe C.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''The Netherlands:''' 2C-B-FLY is a controlled substance as of July 1, 2025. <ref>{{Citation|title= Bepaalde groepen designerdrugs (ook wel nieuwe psychoactieve stoffen) zijn sinds 1 juli 2025 verboden. Deze stoffen zijn schadelijk. Gebruikers kunnen er gezondheidsproblemen van krijgen en er zelfs door overlijden. | year=2025|url=https://www.rijksoverheid.nl/onderwerpen/drugs/verbod-op-designerdrugs}}</ref>
*'''Turkey:''' 2C-B-FLY is a classed as drug and is illegal to possess, produce, supply, or import.<ref name="Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742">https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm</ref> <ref name="List of illegal substances for law"> https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf</ref>
*'''United Kingdom''': It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>{{Citation | title=Psychoactive Substances Act 2016 | url=https://www.legislation.gov.uk/ukpga/2016/2/contents/enacted}}</ref>
*'''United States''': 2C-B-FLY is unscheduled and uncontrolled in the United States. However, it may fall under the scope of the Federal Analogue Act if it is intended for human consumption given its similarity to 2C-B.<ref>Drug control: Highlights of P.L. 99-570, Anti Drug Abuse Act of 1986: (drug-related provisions only) (1986). bill.</ref><ref>"[https://www.deadiversion.usdoj.gov/schedules/orangebook/e_cs_sched.pdf#page=1 Controlled Substances: by CSA Schedule]" (PDF). U.S. Department of Justice. November 18, 2021. p. 1.</ref>


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Psychedelics]]
*[[Psychedelic]]
*[[Phenethylamines]]
*[[Phenethylamine]]
*[[Bromo-DragonFLY]]
*[[Bromo-DragonFLY]]
*[[2C-x]]
*[[2C-x]]
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==External links==
==External links==
*[https://en.wikipedia.org/wiki/2C-B-FLY 2C-B-FLY (Wikipedia)]
*[https://en.wikipedia.org/wiki/2C-B-FLY 2C-B-FLY (Wikipedia)]
*[https://www.erowid.org/chemicals/2cb_fly/2cb_fly.shtml 2C-B-FLY (Erowid)]
*[https://erowid.org/chemicals/2cb_fly/2cb_fly.shtml 2C-B-FLY (Erowid Vault)]
*[http://drugs.tripsit.me/2c-b-fly 2C-B-FLY (TripSit)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=2021 2C-B-FLY (Isomer Design)]
*[http://www.bluelight.org/vb/threads/225385-The-Big-amp-Dandy-2C-B-FLY-Thread 2C-B-FLY (Bluelight)]
 
*[https://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=2021 2C-B-FLY (Isomer Design)]
===Discussion===
 
*[http://www.bluelight.org/vb/threads/225385-The-Big-amp-Dandy-2C-B-FLY-Thread The Big & Dandy 2C-B-Fly Thread (Bluelight)]
 
==Literature==
 
*Greene, S. L. (2013). Benzofurans and benzodifurans. In Novel Psychoactive Substances (pp. 383-392). https://doi.org/10.1016/B978-0-12-415816-0.00016-X


==References==
==References==
<references />
<references />
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Hallucinogen]]
[[Category:2C-x]]
[[Category:Benzodihydrofuran]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
[[Category:Phenethylamine]]
[[Category:Research chemical]]
[[Category:Benzodihydrofuran]]
 
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