4-AcO-DET: Difference between revisions

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==Chemistry==

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains ~~isopropyl and methyl~~ chains bound to the terminal amine RN of its tryptamine backbone ([[DET]]).

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone ([[DET]]).

4-AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] (psilocin). 4-AcO-DET is the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/24801867|title=Compound Summary - 3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate|website=PubChem|access-date=July 18, 2020}}</ref> It is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]].

4-substituted acetylated tryptamines such as [[4-AcO-DET]], 4-AcO-MET, and 4-AcO-DMT are hypothesized to principally act as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}}

==Pharmacology==

4-substituted acetylated tryptamines such as 4-AcO-DET, [[4-AcO-MET]], and [[4-AcO-DMT]] are hypothesized to principally act as a [[prodrug]] for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}}

Like with most [[psychedelic]] tryptamines, 4-AcO-DET is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT2A]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-AcO-DET's binding efficacy at the 5-HT2A receptors.

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===Experience reports===

~~There are currently no anecdotal~~ reports ~~which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:~~

{{Experience reports|erowid_experience_substance_label=4-AcO-DET}}

* [https://www.erowid.org/experiences/subs/exp_4AcODET.shtml Erowid Experience Vaults: 4-AcO-DET]

==Toxicity and harm potential==

{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational 4-AcO-DET has not been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]].

This is because 4-AcO-DET is a [[research chemical]] with a very limited history of human usage.

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*'''Germany''': Because it is an ester of DET, 4-AcO-DET is controlled under Anlage I BtMG (Narcotics Act, Schedule I)<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html|title=Betäubungsmittelgesetz (BtMG) Anlage I|trans-title=Narcotics Act (BtMG) Schedule I|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> as of January 24, 1974.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl174s0097.pdf|title=Sechste Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe|publisher=Bundesanzeiger Verlag [Federal Gazette]|language=de|eissn=0344-7634|page=97|work=Bundesgesetzblatt Jahrgang 1974 Teil I Nr. 6|date=January 17, 1974|publication-date=January 23, 1974}}</ref> It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/__29.html|title=Betäubungsmittelgesetz (BtMG) § 29|trans-title=Narcotics Act (BtMG) § 29|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref>

*'''Japan''': 4-AcO-DET is a controlled substance in Japan effective July 29th, 2015.<ref>{{Citation | title=危険ドラッグの成分４物質を新たに指定薬物に指定 | publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)] | url=https://www.mhlw.go.jp/stf/houdou/0000092698.html | language=japanese | access-date=2 May 2022}}</ref>

*'''Switzerland''': 4-AcO-DET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>

*'''Turkey:''' 4-AcO-DET is a classed as drug and is illegal to possess, produce, supply, or import.<ref ~~name~~="Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742">https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm</ref> <ref ~~name~~=~~"List of illegal substances for law">~~ https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf</ref>

*'''Sweden''': 4-AcO-DET was classified under the Act on the Prohibition of Certain Goods Dangerous to Health on November 1, 2005, making it illegal to sell or possess.<ref name="notisum">{{cite web|url=http://www.notisum.se/rnp/sls/sfs/20050733.pdf|date=October 6, 2005|publication-date=October 18, 2005|title=Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor|publisher=Läkemedelsverket [Medical Products Agency]|id=SFS 2005:733|language=sv|work=Svensk författningssamling|issn=1101-5225}}</ref>

*'''Turkey:''' 4-AcO-DET is a classed as drug and is illegal to possess, produce, supply, or import.<ref>{{cite web|title=Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr}}</ref><ref>{{cite web|title=Kararnamenin Eki: Liste|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr|id=2013/5742|work=Resmî Gazete, Sayı: 28893}}</ref>

*'''United Kingdom''': 4-AcO-DET is a Class A drug in the UK as it is an ester of the drug [[4-HO-DET]], which is a Class A drug as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=January 7, 2020|publisher=UK Government}}</ref>

*'''United States''': 4-AcO-DET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}

==See also==

*[[Responsible use]]

*[[Research chemical]]

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==External links==

*[https://en.wikipedia.org/wiki/4-AcO-DET 4-AcO-DET (Wikipedia)]

*[https://erowid.org/chemicals/4_acetoxy_det/4_acetoxy_det.shtml 4-AcO-DET (Erowid Vault)]

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==References==

~~[[Category:Substance]]~~

[[Category:Psychoactive substance]]

[[Category:~~Hallucinogen~~]]

[[Category:Tryptamine]]

[[Category:Psychedelic]]

~~[[Category:Tryptamine]]~~

[[Category:Research chemical]]

@@ Line 9: / Line 9: @@
 ==Chemistry==
--AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R<sub>4</sub> of its indole heterocycle with an acetoxy (AcO) functional group CH<sub>3</sub>COO−. It also contains isopropyl and methyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DET]]).
+-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R<sub>4</sub> of its indole heterocycle with an acetoxy (AcO) functional group CH<sub>3</sub>COO−. It also contains two ethyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DET]]).
 -AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] (psilocin). 4-AcO-DET is the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/24801867|title=Compound Summary - 3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate|website=PubChem|access-date=July 18, 2020}}</ref> It is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]].
--substituted acetylated tryptamines such as [[4-AcO-DET]], 4-AcO-MET, and 4-AcO-DMT are hypothesized to principally act as a prodrug for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}}
 ==Pharmacology==
 {{Further|Serotonergic psychedelic}}
+-substituted acetylated tryptamines such as 4-AcO-DET, [[4-AcO-MET]], and [[4-AcO-DMT]] are hypothesized to principally act as a [[prodrug]] for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}}
 Like with most [[psychedelic]] tryptamines, 4-AcO-DET is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-AcO-DET's binding efficacy at the 5-HT<sub>2A</sub> receptors.
@@ Line 115: / Line 115: @@
 ===Experience reports===
-There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
+{{Experience reports|erowid_experience_substance_label=4-AcO-DET}}
-* [https://www.erowid.org/experiences/subs/exp_4AcODET.shtml Erowid Experience Vaults: 4-AcO-DET]
 ==Toxicity and harm potential==
-{{Further|Responsible use#Hallucinogens}}
+{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
 The toxicity and long-term health effects of recreational 4-AcO-DET has not been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]].
 This is because 4-AcO-DET is a [[research chemical]] with a very limited history of human usage.
@@ Line 144: / Line 143: @@
 *'''Germany''': Because it is an ester of DET, 4-AcO-DET is controlled under Anlage I BtMG (Narcotics Act, Schedule I)<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html|title=Betäubungsmittelgesetz (BtMG) Anlage I|trans-title=Narcotics Act (BtMG) Schedule I|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> as of January 24, 1974.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl174s0097.pdf|title=Sechste Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe|publisher=Bundesanzeiger Verlag [Federal Gazette]|language=de|eissn=0344-7634|page=97|work=Bundesgesetzblatt Jahrgang 1974 Teil I Nr. 6|date=January 17, 1974|publication-date=January 23, 1974}}</ref> It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/__29.html|title=Betäubungsmittelgesetz (BtMG) § 29|trans-title=Narcotics Act (BtMG) § 29|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref>
+*'''Japan''': 4-AcO-DET is a controlled substance in Japan effective July 29th, 2015.<ref>{{Citation | title=危険ドラッグの成分４物質を新たに指定薬物に指定 | publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)] | url=https://www.mhlw.go.jp/stf/houdou/0000092698.html | language=japanese | access-date=2 May 2022}}</ref>
 *'''Switzerland''': 4-AcO-DET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
-*'''Turkey:''' 4-AcO-DET is a classed as drug and is illegal to possess, produce, supply, or import.<ref name="Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742">https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm</ref> <ref name="List of illegal substances for law"> https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf</ref>
+*'''Sweden''':  4-AcO-DET was classified under the Act on the Prohibition of Certain Goods Dangerous to Health on November 1, 2005, making it illegal to sell or possess.<ref name="notisum">{{cite web|url=http://www.notisum.se/rnp/sls/sfs/20050733.pdf|date=October 6, 2005|publication-date=October 18, 2005|title=Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor|publisher=Läkemedelsverket [Medical Products Agency]|id=SFS 2005:733|language=sv|work=Svensk författningssamling|issn=1101-5225}}</ref>
+*'''Turkey:''' 4-AcO-DET is a classed as drug and is illegal to possess, produce, supply, or import.<ref>{{cite web|title=Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr}}</ref><ref>{{cite web|title=Kararnamenin Eki: Liste|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr|id=2013/5742|work=Resmî Gazete, Sayı: 28893}}</ref>
 *'''United Kingdom''': 4-AcO-DET is a Class A drug in the UK as it is an ester of the drug [[4-HO-DET]], which is a Class A drug as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=January 7, 2020|publisher=UK Government}}</ref>
 *'''United States''': 4-AcO-DET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
 ==See also==
 *[[Responsible use]]
 *[[Research chemical]]
@@ Line 159: / Line 161: @@
 ==External links==
 *[https://en.wikipedia.org/wiki/4-AcO-DET 4-AcO-DET (Wikipedia)]
 *[https://erowid.org/chemicals/4_acetoxy_det/4_acetoxy_det.shtml 4-AcO-DET (Erowid Vault)]
@@ Line 168: / Line 171: @@
 ==References==
-<references/>
+<references />
-[[Category:Substance]]
 [[Category:Psychoactive substance]]
-[[Category:Hallucinogen]]
+[[Category:Tryptamine]]
 [[Category:Psychedelic]]
-[[Category:Tryptamine]]
 [[Category:Research chemical]]
 {{#set:Featured=true}}