4-AcO-DET: Difference between revisions
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{{SubstanceBox/4-AcO-DET}} | {{SubstanceBox/4-AcO-DET}} | ||
'''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine''', '''ethacetin''') is | '''4-AcO-DET''' ('''4-Acetoxy-N,N-diethyltryptamine''', '''ethacetin''') is a lesser-known novel [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class. It is chemically related to [[psilocin]] and part of a series of substituted tryptamines that includes 4-AcO-MET and 4-AcO-DMT. | ||
Today it is either used recreationally as a [[designer drug]] or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. | |||
There is very little data on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection.<ref>{{cite journal|title=Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography–mass spectrometry|pmid=19084633|doi=10.1016/j.talanta.2008.07.062|last1=Takahashi|first1=M.|last2=Nagashima|first2=M.|last3=Suzuki|first3=J.|last4=Yasuda|first4=I|last5=Yoshida|first5=T.|volume=77|issue=4|date=February 15, 2009|pages=1245-1272|issn=0039-9140|eissn=1873-3573|oclc=01767116}}</ref> It remains relatively rare and has very little documented history of human usage. It is highly advised to use [[harm reduction practices]] if using this substance. | |||
==Chemistry== | ==Chemistry== | ||
4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R<sub>4</sub> of its indole heterocycle with an acetoxy (AcO) functional group CH<sub>3</sub>COO−. It also contains | 4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R<sub>4</sub> of its indole heterocycle with an acetoxy (AcO) functional group CH<sub>3</sub>COO−. It also contains two ethyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DET]]). | ||
4-AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] (psilocin). 4-AcO-DET is the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref> | 4-AcO-DET is the N-substituted diethyl homolog of [[4-HO-DMT]] (psilocin). 4-AcO-DET is the acetate ester analog of [[DET]] and the N-substituted diethyl analog of [[4-AcO-DMT]].<ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/24801867|title=Compound Summary - 3-(2-(Diethylamino)ethyl)-1H-indol-4-yl acetate|website=PubChem|access-date=July 18, 2020}}</ref> It is a higher homolog of [[4-AcO-DMT]] and [[4-AcO-MET]]. | ||
==Pharmacology== | ==Pharmacology== | ||
{{Further|Serotonergic psychedelic}} | {{Further|Serotonergic psychedelic}} | ||
4-substituted acetylated tryptamines such as 4-AcO-DET, [[4-AcO-MET]], and [[4-AcO-DMT]] are hypothesized to principally act as a [[prodrug]] for their respective hydrolyzed counterparts (e.g. [[4-HO-DMT]], [[4-HO-MET]] and [[4-HO-DET]]). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.{{citation needed}} | |||
Like with most [[psychedelic]] tryptamines, 4-AcO-DET is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-AcO-DET's binding efficacy at the 5-HT<sub>2A</sub> receptors. | Like with most [[psychedelic]] tryptamines, 4-AcO-DET is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-AcO-DET's binding efficacy at the 5-HT<sub>2A</sub> receptors. | ||
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===Experience reports=== | ===Experience reports=== | ||
{{Experience reports|erowid_experience_substance_label=4-AcO-DET}} | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{ | {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}} | ||
The toxicity and long-term health effects of recreational 4-AcO-DET has not been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. | The toxicity and long-term health effects of recreational 4-AcO-DET has not been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. | ||
This is because 4-AcO-DET is a [[research chemical]] with a very limited history of human usage. | This is because 4-AcO-DET is a [[research chemical]] with a very limited history of human usage. | ||
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Due to its relative obscurity, the possession and sale of 4-AcO-DET is unscheduled in most countries. | Due to its relative obscurity, the possession and sale of 4-AcO-DET is unscheduled in most countries. | ||
*'''Germany''': Because it is an ester of DET, 4-AcO-DET is controlled under Anlage I BtMG (Narcotics Act, Schedule I) | *'''Germany''': Because it is an ester of DET, 4-AcO-DET is controlled under Anlage I BtMG (Narcotics Act, Schedule I)<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html|title=Betäubungsmittelgesetz (BtMG) Anlage I|trans-title=Narcotics Act (BtMG) Schedule I|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> as of January 24, 1974.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl174s0097.pdf|title=Sechste Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe|publisher=Bundesanzeiger Verlag [Federal Gazette]|language=de|eissn=0344-7634|page=97|work=Bundesgesetzblatt Jahrgang 1974 Teil I Nr. 6|date=January 17, 1974|publication-date=January 23, 1974}}</ref> It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.<ref>{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/__29.html|title=Betäubungsmittelgesetz (BtMG) § 29|trans-title=Narcotics Act (BtMG) § 29|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> | ||
*'''Japan''': 4-AcO-DET is a controlled substance in Japan effective July 29th, 2015.<ref>{{Citation | title=危険ドラッグの成分4物質を新たに指定薬物に指定 | publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)] | url=https://www.mhlw.go.jp/stf/houdou/0000092698.html | language=japanese | access-date=2 May 2022}}</ref> | |||
*'''Switzerland''': 4-AcO-DET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref> | *'''Switzerland''': 4-AcO-DET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref> | ||
*''' | *'''Sweden''': 4-AcO-DET was classified under the Act on the Prohibition of Certain Goods Dangerous to Health on November 1, 2005, making it illegal to sell or possess.<ref name="notisum">{{cite web|url=http://www.notisum.se/rnp/sls/sfs/20050733.pdf|date=October 6, 2005|publication-date=October 18, 2005|title=Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor|publisher=Läkemedelsverket [Medical Products Agency]|id=SFS 2005:733|language=sv|work=Svensk författningssamling|issn=1101-5225}}</ref> | ||
*'''Turkey:''' 4-AcO-DET is a classed as drug and is illegal to possess, produce, supply, or import.<ref>{{cite web|title=Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr}}</ref><ref>{{cite web|title=Kararnamenin Eki: Liste|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr|id=2013/5742|work=Resmî Gazete, Sayı: 28893}}</ref> | |||
*'''United Kingdom''': 4-AcO-DET is a Class A drug in the UK as it is an ester of the drug [[4-HO-DET]], which is a Class A drug as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=January 7, 2020|publisher=UK Government}}</ref> | |||
*'''United States''': 4-AcO-DET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}} | *'''United States''': 4-AcO-DET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}} | ||
==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Research chemical]] | *[[Research chemical]] | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/4-AcO-DET 4-AcO-DET (Wikipedia)] | *[https://en.wikipedia.org/wiki/4-AcO-DET 4-AcO-DET (Wikipedia)] | ||
*[https://erowid.org/chemicals/4_acetoxy_det/4_acetoxy_det.shtml 4-AcO-DET (Erowid Vault)] | *[https://erowid.org/chemicals/4_acetoxy_det/4_acetoxy_det.shtml 4-AcO-DET (Erowid Vault)] | ||
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==References== | ==References== | ||
<references/> | <references /> | ||
[[Category:Psychoactive substance]] | [[Category:Psychoactive substance]] | ||
[[Category: | [[Category:Tryptamine]] | ||
[[Category:Psychedelic]] | [[Category:Psychedelic]] | ||
[[Category:Research chemical]] | [[Category:Research chemical]] | ||
{{#set:Featured=true}} | {{#set:Featured=true}} |