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Salvinorin B methoxymethyl ether: Difference between revisions

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'''Salvinorin B methoxymethyl ether''' ('''2-O-methoxymethylsalvinorin B''', or '''2-MMSB''') is a semi-synthetic analogue of the natural product [[Salvinorin A]] which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.
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'''Salvinorin B methoxymethyl ether''' (2-O-methoxymethylsalvinorin B) is a semi-synthetic analogue of the natural product [[Salvinorin A]] which is used in scientific research. It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. Like the related compound herkinorin, salvinorin B methoxymethyl ether is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant Salvia divinorum, salvinorin A is present in larger quantities.


Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its stronger homolog salvinorin B ethoxymethyl ether.
Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its stronger homolog salvinorin B ethoxymethyl ether.
===Experience reports===
{{Experience reports|erowid_experience_substance_label=Salvinorin B Ethoxymethyl Ether}}


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Salvinorin A]]
*[[Salvinorin A]]
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*[[Psychoactive substance index]]
*[[Psychoactive substance index]]


==External links==
*[https://en.wikipedia.org/wiki/Salvinorin_B_methoxymethyl_ether Salvinorin B methoxymethyl ether (Wikipedia)]
*[https://www.erowid.org/chemicals/salvinorin_b_ethoxymethyl_ether/ Salvinorin B methoxymethyl ether (Erowid Vault)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=2842 Salvinorin B methoxymethyl ether (Isomer Design)]
==References==
{{references}}
[[Category:Hallucinogen]]
[[Category:Dissociative]]
[[Category:Dissociative]]
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Substance]]
[[Category:Salvinorin]]
[[Category:Terpenoid]]
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