Talk:Olanzapine: Difference between revisions

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~~==initial draft. This will contain a myriad of information and will be formatted later :) --[[User:Corticosteroid|Corticosteroid]] ([[User talk:Corticosteroid|talk]]) 22:58, 20 October 2017 (CEST)==~~

~~[[File:~~Olanzapine~~.svg|250px|thumbnail|right|Structure of olanzapine.]]~~

[[File:Apotex-manufactured olanzapine 5 mg ODT.jpg|400px|thumbnail|right|A five milligram tablet of olanzapine manufactured by Apotex. This tablet is designed to dissolve in the mouth and be absorbed through the blood vessels inside of the mouth.]]

'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. {{citation needed}}

'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine is known to cause weight gain and help induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref> Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] ~~Telenzepine is another agent that shares the thienobenzodiazepine core structure.~~ Olanzapine as useful as a trip aborter, especially for stimulants.

~~:(doses:~~

==Chemistry==

~~:Light: 2~~.~~5 mg~~

Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety at R<sub>4</sub>.

~~:Medium: 5~~ to 7.5 mg

:~~Heavy~~: ~~10 mg~~

Olanzapine is classified as a thienobenzodiazepine derivative. Its chemical structure consists of a fused tricyclic system incorporating a thiophene ring and a diazepine ring. Specifically, olanzapine features a piperazine substituent at the R4 position of the diazepine moiety. This piperazine ring is believed to contribute to its affinity for various neurotransmitter receptors, particularly serotonergic and dopaminergic sites. The compound has a molecular formula of C17H20N4OS, with a molecular weight of 312.44 g/mol. Its IUPAC name is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. [[User:Syrex1013|Syrex1013]] ([[User talk:Syrex1013|talk]]) 00:26, 27 June 2025 (UTC)

:~~Strong: 10 mg +~~)

==Pharmacology==

Olanzapine is known to cause weight gain and induce diabetes mellitus type 2 more frequently than other [[antipsychotics]]. However, it is less likely to produce tardive dyskinesia or an extrapyramidal reaction. It appears to be an effective treatment for schizophrenia.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref>

==Subjective effects==

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}}

|{{effects/cognitive|

*'''[[Anxiety suppression]]''' - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and ~~serotonergic~~ action rather than GABA-related activity.

*'''[[Anxiety suppression]]''' - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and antiserotonergic action rather than GABA-related activity.

*'''[[Emotionality suppression]]''' - Olanzapine dulls and suppresses emotions.

*'''[[Focus suppression]] or [[Focus enhancement|enhancement]]''' - This often depends on the mental state of the individual.

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*'''[[Sleepiness]]'''

*'''[[Cognitive euphoria]]''' - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.

*'''[[Cognitive dysphoria]]''' - This often includes ~~an extreme~~ sense of boredom or depression accompanied by uncomfortable sedation.

*'''[[Cognitive dysphoria]]''' - This often includes a sense of boredom or depression accompanied by uncomfortable sedation.

}}

===Experience reports===

There are currently {{#ask:[[Category:Olanzapine]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].

{{#ask: [[Category:Olanzapine]][[Category:Experience]]|format=ul|Columns=1}}

Additional experience reports can be found here:

* [https://erowid.org/experiences/subs/exp_Pharms_Olanzapine.shtml Erowid Experience Vaults: Olanzapine]

==External links==

*[[wikipedia:Olanzapine|Olanzapine (Wikipedia)]]

*[https://www.erowid.org/pharms/olanzapine Olanzapine (Erowid Vault)]

*[https://go.drugbank.com/drugs/DB00334 Olanzapine (DrugBank)]

*[https://www.drugs.com/olanzapine.html Olanzapine (Drugs.com)]

==References==

[[Category:Approval]]

[[Category:Proofread]]

@@ Line 1: / Line 1: @@
-==initial draft. This will contain a myriad of information and will be formatted later :) --[[User:Corticosteroid|Corticosteroid]] ([[User talk:Corticosteroid|talk]]) 22:58, 20 October 2017 (CEST)==
+{{SummarySheet}}
-[[File:Olanzapine.svg|250px|thumbnail|right|Structure of olanzapine.]]
+{{SubstanceBox/Olanzapine}}
-[[File:Apotex-manufactured olanzapine 5 mg ODT.jpg|400px|thumbnail|right|A five milligram tablet of olanzapine manufactured by Apotex. This tablet is designed to dissolve in the mouth and be absorbed through the blood vessels inside of the mouth.]]
+'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine. {{citation needed}}
-'''Olanzapine''', first branded as '''Zyprexa''', is a widely-used [[psychoactive class::antipsychotic]] substance of the [[chemical class::thienobenzodiazepine]] chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine is known to cause weight gain and help induce Diabetes mellitus type 2 more frequently than other antipsychotics. On the other hand, it has less of a chance of producing tardive dyskinesia or an extrapyramidal reaction and also seems to treat schizophrenia very effectively.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref> Olanzapine can be given [[Routes of Administration#Oral|by mouth]] and can also be [[Routes of Administration#Intramuscular|injected into a muscle.]] Telenzepine is another agent that shares the thienobenzodiazepine core structure. Olanzapine as useful as a trip aborter, especially for stimulants.
-:(doses:
+==Chemistry==
-:Light: 2.5 mg
+Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety at R<sub>4</sub>.
-:Medium: 5 to 7.5 mg
-:Heavy: 10 mg
+Olanzapine is classified as a thienobenzodiazepine derivative. Its chemical structure consists of a fused tricyclic system incorporating a thiophene ring and a diazepine ring. Specifically, olanzapine features a piperazine substituent at the R4 position of the diazepine moiety. This piperazine ring is believed to contribute to its affinity for various neurotransmitter receptors, particularly serotonergic and dopaminergic sites. The compound has a molecular formula of C17H20N4OS, with a molecular weight of 312.44 g/mol. Its IUPAC name is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. [[User:Syrex1013|Syrex1013]] ([[User talk:Syrex1013|talk]]) 00:26, 27 June 2025 (UTC)
-:Strong: 10 mg +)
+==Pharmacology==
+Olanzapine is known to cause weight gain and induce diabetes mellitus type 2 more frequently than other [[antipsychotics]]. However, it is less likely to produce tardive dyskinesia or an extrapyramidal reaction. It appears to be an effective treatment for schizophrenia.<ref>Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., ... & Kissling, W. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet, 382(9896), 951-962.</ref>
 ==Subjective effects==
@@ Line 26: / Line 27: @@
 }}
 |{{effects/cognitive|
-*'''[[Anxiety suppression]]''' - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and serotonergic action rather than GABA-related activity.
+*'''[[Anxiety suppression]]''' - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and antiserotonergic action rather than GABA-related activity.
 *'''[[Emotionality suppression]]''' - Olanzapine dulls and suppresses emotions.
 *'''[[Focus suppression]] or [[Focus enhancement|enhancement]]''' - This often depends on the mental state of the individual.
@@ Line 32: / Line 33: @@
 *'''[[Sleepiness]]'''
 *'''[[Cognitive euphoria]]''' - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.
-*'''[[Cognitive dysphoria]]''' - This often includes an extreme sense of boredom or depression accompanied by uncomfortable sedation.
+*'''[[Cognitive dysphoria]]''' - This often includes a sense of boredom or depression accompanied by uncomfortable sedation.
 }}
 }}
+===Experience reports===
+There are currently {{#ask:[[Category:Olanzapine]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
+{{#ask: [[Category:Olanzapine]][[Category:Experience]]|format=ul|Columns=1}}
+Additional experience reports can be found here:
+* [https://erowid.org/experiences/subs/exp_Pharms_Olanzapine.shtml Erowid Experience Vaults: Olanzapine]
+==External links==
+*[[wikipedia:Olanzapine|Olanzapine (Wikipedia)]]
+*[https://www.erowid.org/pharms/olanzapine Olanzapine (Erowid Vault)]
+*[https://go.drugbank.com/drugs/DB00334 Olanzapine (DrugBank)]
+*[https://www.drugs.com/olanzapine.html Olanzapine (Drugs.com)]
+==References==
+<references />
+[[Category:Approval]]
+[[Category:Proofread]]