Myristicin: Difference between revisions

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'''Myristicin''' is a [[naturally-occurring]] [[psychoactive class::deliriant]] substance of the [[Chemical class::phenylpropene]] class. It is present in small amounts in the essential oil of nutmeg and, to a lesser extent, in other spices such as [[parsley]] and [[dill]].<ref>http://www.lktlabs.com/products/Myristicin-126-50.html</ref> It has been shown to act on the [[Cannabinoid|endocannabinoid system]].<ref>{{cite journal | vauthors=((El-Alfy, A. T.)), ((Abourashed, E. A.)), ((Patel, C.)), ((Mazhari, N.)), ((An, H.)), ((Jeon, A.)) | journal=Journal of Pharmacy and Pharmacology | title=Phenolic compounds from nutmeg ( Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase | volume=71 | issue=12 | pages=1879–1889 | date=8 November 2019 | url=https://academic.oup.com/jpp/article/71/12/1879-1889/6122229 | issn=2042-7158 | doi=10.1111/jphp.13174}}</ref>

Myristicin, along with [[elemicin]], is thought to be the main psychoactive constituent of nutmeg.{{citation needed}} Additionally, myristicin is the traditional precursor for the [[psychedelic]] and [[empathogenic]] drug [[MMDA]].{{citation needed}}

Myristicin, along with [[elemicin]], is thought to be the main psychoactive constituent of nutmeg.{{citation needed}} When oxidized with Potassium permanganate, Myristicin can be converted into Myristicinaldehyde, which can then be used to synthesize MMDPEA (Lophophine) via reductive amination.{{citation needed}} Additionally, myristicin is the traditional precursor for the [[psychedelic]] and [[empathogenic]] drug [[MMDA]].{{citation needed}}

Nutmeg is reported to induce hallucinogenic effects, such as visual distortions and paranoid ideation. In the reports, nutmeg intoxication took several hours before maximum effect was reached. Effects and after-effects lasted up to several days. Raw nutmeg consists of 5-15% essential oil by mass. 4-8.5% of nutmeg essential oil, or 0.2-1.3% of raw nutmeg, is myristicin. One study found 20 grams of nutmeg to contain 210 mg myristicin.

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====Elemicin====

Elemicin is found in nutmeg alongside myristicin and contributes to its [[hallucinogenic]] effects. Elemicin is likely to have similar effects to myristicin. It is also the traditional precursor in synthesizing the alkaloid [[mescaline]].{{citation needed}}

people who have ingested Elemi oil, (a source of elemicin that exists without high amounts of Myristicin) have claimed the visual effects the oil produce seem to be more similar to classical hallucinogens than the visual effects of nutmeg oil, (which seem to be more delirious and sedating in nature)

This distinction seems to paint Myristicin as a more sedating and mind-dulling drug, while Elemicin seems to be more-visually active and stimulating. this assumption is further supported by the fact that while Elemicin has direct structural ties to Mescaline, Myristicin has ties to [[MDxx|MDXX]] compounds such as [[MDMA]].

The chemical structure of Elemicin appears to be a carbon-based analogue of [[Mescaline]] while Myristicin itself appears to be a carbon analogue of Lophophine, these structural differences may be indicators of the slightly different psychoactive effects both Elemicin and Myristicin have.

====Cannabinoids====

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*'''[[Effect::Sedation]]''' - This effect can be extremely strong at higher dosage, leaving the user in a near sleep state during the experience.

*'''[[Effect::Stimulation]]''' - This effect occurs on lower doses.

*'''[[Effect::Motor control loss]]''' ~~- This effect is very similar to alcohol.~~

*'''[[Effect::Motor control loss]]'''

*'''[[Effect::Muscle relaxation]]''' ~~- This effect is similar to alcohol and tends to occur at lower doses.~~

*'''[[Effect::Muscle relaxation]]'''

*'''[[Effect::Perception of bodily heaviness]]''' ~~- This effect is similar to alcohol.~~

*'''[[Effect::Perception of bodily heaviness]]'''

*'''[[Effect::Photophobia]]'''

*'''[[Effect::Spontaneous tactile sensations]]'''

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 '''Myristicin''' is a [[naturally-occurring]] [[psychoactive class::deliriant]] substance of the [[Chemical class::phenylpropene]] class. It is present in small amounts in the essential oil of nutmeg and, to a lesser extent, in other spices such as [[parsley]] and [[dill]].<ref>http://www.lktlabs.com/products/Myristicin-126-50.html</ref> It has been shown to act on the [[Cannabinoid|endocannabinoid system]].<ref>{{cite journal | vauthors=((El-Alfy, A. T.)), ((Abourashed, E. A.)), ((Patel, C.)), ((Mazhari, N.)), ((An, H.)), ((Jeon, A.)) | journal=Journal of Pharmacy and Pharmacology | title=Phenolic compounds from nutmeg ( Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase | volume=71 | issue=12 | pages=1879–1889 | date=8 November 2019 | url=https://academic.oup.com/jpp/article/71/12/1879-1889/6122229 | issn=2042-7158 | doi=10.1111/jphp.13174}}</ref>
-Myristicin, along with [[elemicin]], is thought to be the main psychoactive constituent of nutmeg.{{citation needed}} Additionally, myristicin is the traditional precursor for the [[psychedelic]] and [[empathogenic]] drug [[MMDA]].{{citation needed}}
+Myristicin, along with [[elemicin]], is thought to be the main psychoactive constituent of nutmeg.{{citation needed}}  When oxidized with Potassium permanganate, Myristicin can be converted into Myristicinaldehyde, which can then be used to synthesize MMDPEA (Lophophine) via reductive amination.{{citation needed}} Additionally, myristicin is the traditional precursor for the [[psychedelic]] and [[empathogenic]] drug [[MMDA]].{{citation needed}}
 Nutmeg is reported to induce hallucinogenic effects, such as visual distortions and paranoid ideation. In the reports, nutmeg intoxication took several hours before maximum effect was reached. Effects and after-effects lasted up to several days. Raw nutmeg consists of 5-15% essential oil by mass. 4-8.5% of nutmeg essential oil, or 0.2-1.3% of raw nutmeg, is myristicin. One study found 20 grams of nutmeg to contain 210 mg myristicin.
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 ====Elemicin====
 Elemicin is found in nutmeg alongside myristicin and contributes to its [[hallucinogenic]] effects. Elemicin is likely to have similar effects to myristicin. It is also the traditional precursor in synthesizing the alkaloid [[mescaline]].{{citation needed}}
+people who have ingested Elemi oil, (a source of elemicin that exists without high amounts of Myristicin) have claimed the visual effects the oil produce seem to be more similar to classical hallucinogens than the visual effects of nutmeg oil, (which seem to be more delirious and sedating in nature)
+This distinction seems to paint Myristicin as a more sedating and mind-dulling drug, while Elemicin seems to be more-visually active and stimulating. this assumption is further supported by the fact that while Elemicin has direct structural ties to Mescaline, Myristicin has ties to [[MDxx|MDXX]] compounds such as [[MDMA]].
+The chemical structure of Elemicin appears to be a carbon-based analogue of [[Mescaline]] while Myristicin itself appears to be a carbon analogue of Lophophine, these structural differences may be indicators of the slightly different psychoactive effects both Elemicin and Myristicin have.
 ====Cannabinoids====
@@ Line 36: / Line 42: @@
 *'''[[Effect::Sedation]]''' - This effect can be extremely strong at higher dosage, leaving the user in a near sleep state during the experience.
 *'''[[Effect::Stimulation]]''' - This effect occurs on lower doses.
-*'''[[Effect::Motor control loss]]''' - This effect is very similar to alcohol.
+*'''[[Effect::Motor control loss]]'''
-*'''[[Effect::Muscle relaxation]]''' - This effect is similar to alcohol and tends to occur at lower doses.
+*'''[[Effect::Muscle relaxation]]'''
-*'''[[Effect::Perception of bodily heaviness]]''' - This effect is similar to alcohol.
+*'''[[Effect::Perception of bodily heaviness]]'''
 *'''[[Effect::Photophobia]]'''
 *'''[[Effect::Spontaneous tactile sensations]]'''