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Talk:Salbutamol: Difference between revisions
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==History and culture== | ==History and culture== | ||
Salbutamol was discovered 1966, by a | Salbutamol was discovered 1966, by a team lead by David Jack, the first medication launched was ''[[wikipedia:Ventolin|Ventolin]]''. Until today Salbutamol remains one of the most effective rescue inhalers {{citation needed}}.<ref name=SirDavidJack_telegraph> | ||
{{cite news|title=Sir David Jack, who has died aged 87, was the scientific brain behind the rise of the pharmaceuticals company Glaxo|url=https://www.telegraph.co.uk/news/obituaries/finance-obituaries/8897458/Sir-David-Jack.html|newspaper=The Telegraph|date=17 November 2011 | {{cite news|title=Sir David Jack, who has died aged 87, was the scientific brain behind the rise of the pharmaceuticals company Glaxo|url=https://www.telegraph.co.uk/news/obituaries/finance-obituaries/8897458/Sir-David-Jack.html|newspaper=The Telegraph|date=17 November 2011|archive-url=https://web.archive.org/web/20111125011155/http://www.telegraph.co.uk/news/obituaries/finance-obituaries/8897458/Sir-David-Jack.html|archive-date=25 November 2011}}</ref> | ||
Salbutamol has a history | Salbutamol has a history of being used for doping due to its bronchodilating effects.<ref name="Fitch 2017 pp. 977–982">{{cite journal | last=Fitch | first=Ken D. | title=The enigma of inhaled salbutamol and sport: unresolved after 45 years | journal=Drug Testing and Analysis | volume=9 | issue=7 | date=2017 | issn=1942-7603 | doi=10.1002/dta.2184 | pages=977–982}}</ref> | ||
==Chemistry== | ==Chemistry== | ||
{{chemistry}} | {{chemistry}} | ||
Salbutamol is sold as a [[racemic mixture]]. The (R)-(−)-enantiomer (CIP nomenclature) is shown in the image at right (top), and is responsible for the pharmacologic activity; the (S)-(+)-enantiomer (bottom) blocks metabolic pathways associated with elimination of itself and of the pharmacologically active enantiomer (R)<ref name="PharmaXChange.info 2011 i568">{{cite web | last=Metha | first Akul | title=Adrenergics and Cholinergic their Biosynthesis, Metabolism and Structure Activity Relationships | website=PharmaXChange.info | date=2011-01-27 | url=https://pharmaxchange.info/2011/01/medicinal-chemistry-of-the-peripheral-nervous-system-adrenergics-and-cholinergic-their-biosynthesis-metabolism-and-structure-activity-relationships/ | access-date=2024-03-12}}</ref> | Salbutamol is sold as a [[wikipedia:racemic mixture|racemic mixture]]. The (R)-(−)-enantiomer (CIP nomenclature) is shown in the image at right (top), and is responsible for the pharmacologic activity; the (S)-(+)-enantiomer (bottom) blocks metabolic pathways associated with elimination of itself and of the pharmacologically active enantiomer (R)<ref name="PharmaXChange.info 2011 i568">{{cite web | last=Metha | first=Akul | title=Adrenergics and Cholinergic their Biosynthesis, Metabolism and Structure Activity Relationships | website=PharmaXChange.info | date=2011-01-27 | url=https://pharmaxchange.info/2011/01/medicinal-chemistry-of-the-peripheral-nervous-system-adrenergics-and-cholinergic-their-biosynthesis-metabolism-and-structure-activity-relationships/ | access-date=2024-03-12}}</ref> | ||
==Pharmacology== | ==Pharmacology== | ||
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==Legal status== | ==Legal status== | ||
{{LegalStub}} | {{LegalStub}} | ||
*'''Canada''': Salbutamol is a prescription-only medication.<ref>https://hpr-rps.hres.ca/index.php</ref> | |||
*'''Germany''': Salbutamol is a prescription-only medication. | |||
*'''United Kingdom''': Salbutamol is a prescription-only medication.<ref>https://www.nhs.uk/medicines/salbutamol-inhaler/about-salbutamol-inhalers/</ref> | |||
==See also== | ==See also== | ||
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==External links== | ==External links== | ||
* [https://en.wikipedia.org/wiki/Salbutamol Salbutamol (Wikipedia)] | *[https://en.wikipedia.org/wiki/Salbutamol Salbutamol (Wikipedia)] | ||
*[https://go.drugbank.com/drugs/DB01001 Salbutamol (DrugBank)] | |||
==References== | ==References== | ||