Talk:Salbutamol: Difference between revisions

Salbutamol was discovered 1966, by a Team lead by David Jack, the first medication laucned was ''[[Ventolin]]''. Until today Salbutamol remains one of the most effective rescue inhalers {{citation needed}}.<ref name=SirDavidJack_telegraph>

{{cite news|title=Sir David Jack, who has died aged 87, was the scientific brain behind the rise of the pharmaceuticals company Glaxo|url=https://www.telegraph.co.uk/news/obituaries/finance-obituaries/8897458/Sir-David-Jack.html|newspaper=The Telegraph|date=17 November 2011|url-status=live|archive-url=https://web.archive.org/web/20111125011155/http://www.telegraph.co.uk/news/obituaries/finance-obituaries/8897458/Sir-David-Jack.html|archive-date=25 November 2011}}</ref>

Salbutamol has a history to be used for doping due to its bronchodialating effects.<ref name="Fitch 2017 pp. 977–982">{{cite journal | last=Fitch | first=Ken D. | title=The enigma of inhaled salbutamol and sport: unresolved after 45 years | journal=Drug Testing and Analysis | volume=9 | issue=7 | date=2017 | issn=1942-7603 | doi=10.1002/dta.2184 | pages=977–982}}</ref>

Salbutamol is sold as a [[racemic mixture]]. The (R)-(−)-enantiomer (CIP nomenclature) is shown in the image at right (top), and is responsible for the pharmacologic activity; the (S)-(+)-enantiomer (bottom) blocks metabolic pathways associated with elimination of itself and of the pharmacologically active enantiomer (R)<ref name="PharmaXChange.info 2011 i568">{{cite web | last=Metha | first Akul | title=Adrenergics and Cholinergic their Biosynthesis, Metabolism and Structure Activity Relationships | website=PharmaXChange.info | date=2011-01-27 | url=https://pharmaxchange.info/2011/01/medicinal-chemistry-of-the-peripheral-nervous-system-adrenergics-and-cholinergic-their-biosynthesis-metabolism-and-structure-activity-relationships/ | access-date=2024-03-12}}</ref>

'''Warning:''' Overdose can result in [[lactic acidosis]], [[arrhythmias]], [[tremors]], [[hypoglykemia]] or [[hyperglykemia]].<ref name="Johnson Merrell Bounds 2024 s398">{{cite web | last=Johnson | first=Donavon B. | last2=Merrell | first2=Brigham J. | last3=Bounds | first3=Connor G. | title=Albuterol | publisher=StatPearls Publishing | date=2024-01-10 | pmid=29489143 | url=https://www.ncbi.nlm.nih.gov/books/NBK482272/ | access-date=2024-03-12}}</ref>

*'''[[MAOIs]]''' Increased risk of adverse [[cardiovescular]] events

*'''[[Beta-blockers]]''' neutralize effects

 

*'''[[Diuretics]]''' May  worsen ECG changes and hypoglykemia

*'''[[Digoxin]]'''

* [https://en.wikipedia.org/wiki/Salbutamol Salbutamol (Wikipedia)]