4-HO-MiPT: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
{{Further|Serotonergic psychedelic}} | {{Further|Serotonergic psychedelic}} | ||
4-HO-MiPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive. | 4-HO-MiPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive. 4-HO-MiPT is thought to be a serotonergic psychedelic. Like other serotonergic psychedelics, its method of action is believed to result from its partial agonism of 5-HT<sub>2A</sub> and 5-HT<sub>1A</sub> serotonin receptors.<ref>"4-HO-MiPT". ''Psychedelic Science Review''. 6 January 2020.</ref> | ||
==Subjective effects== | ==Subjective effects== | ||
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*'''[[Effect::Changes in felt bodily form]]''' - This effect is often accompanied by a sense of warmth or [[Unity and interconnectedness#Unity between the self and specific external systems|psychophysical unity]] and usually occurs around or directly after the peak of the experience. Users can feel as if they are physically part of or conjoined with other objects in a seamless continuity. This is usually reported as feeling comfortable, tranquil and mindful, though it can also manifest in the form of bodily tension. | *'''[[Effect::Changes in felt bodily form]]''' - This effect is often accompanied by a sense of warmth or [[Unity and interconnectedness#Unity between the self and specific external systems|psychophysical unity]] and usually occurs around or directly after the peak of the experience. Users can feel as if they are physically part of or conjoined with other objects in a seamless continuity. This is usually reported as feeling comfortable, tranquil and mindful, though it can also manifest in the form of bodily tension. | ||
*'''[[Effect::Changes in felt gravity]]''' | *'''[[Effect::Changes in felt gravity]]''' | ||
*'''[[Effect::Pain relief]]''' - This effect is distinct from | *'''[[Effect::Pain relief]]''' - This effect is distinct from pain relief produced by opioids. It appears to manifest itself as a result of changes in how the user perceives their body, rather than direct suppression of pain. | ||
*'''[[Effect::Nausea]]''' - This effect can be greatly lessened or even completely avoided if the individual has an empty stomach prior to ingestion. It is sometimes recommended that one either refrain from eating for approximately 6 to 8 hours before-hand, or to eat a light meal 3 to 4 hours before if the user is feeling physically fatigued and undernourished. The nausea produced by 4-HO-MiPT is generally considered to be much less prominent than it is with [[Psilocybin#Psilocybin-containing mushrooms|psilocybin mushrooms]], perhaps owing to the fact that there is no fungal-matter the body has to digest when the isolated synthetic form is consumed. | *'''[[Effect::Nausea]]''' - This effect can be greatly lessened or even completely avoided if the individual has an empty stomach prior to ingestion. It is sometimes recommended that one either refrain from eating for approximately 6 to 8 hours before-hand, or to eat a light meal 3 to 4 hours before if the user is feeling physically fatigued and undernourished. The nausea produced by 4-HO-MiPT is generally considered to be much less prominent than it is with [[Psilocybin#Psilocybin-containing mushrooms|psilocybin mushrooms]], perhaps owing to the fact that there is no fungal-matter the body has to digest when the isolated synthetic form is consumed. | ||
*'''[[Effect::Temperature regulation suppression]]''' - 4-HO-MiPT can cause fluctuates in the user's internal sense of temperature, which can manifest as sudden bouts of uncomfortable coldness or warmth, which is why a climate-controllable environment is strongly recommended in terms of a proper setting for a trip. | *'''[[Effect::Temperature regulation suppression]]''' - 4-HO-MiPT can cause fluctuates in the user's internal sense of temperature, which can manifest as sudden bouts of uncomfortable coldness or warmth, which is why a climate-controllable environment is strongly recommended in terms of a proper setting for a trip. | ||
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*'''[[Effect::Watery eyes]]''' | *'''[[Effect::Watery eyes]]''' | ||
*'''[[Effect::Teeth grinding]]''' - This component is considerably less intense when compared with that of substances like [[MDMA]] when it does happen to occur, but happens more readily than with related substances like [[psilocin]] or [[psilocybin]], perhaps owing to the greater degree of stimulation it produces. | *'''[[Effect::Teeth grinding]]''' - This component is considerably less intense when compared with that of substances like [[MDMA]] when it does happen to occur, but happens more readily than with related substances like [[psilocin]] or [[psilocybin]], perhaps owing to the greater degree of stimulation it produces. | ||
*'''[[Effect::Seizure]]'''{{citation needed}} - This is | *'''[[Effect::Seizure]]'''{{citation needed}} - This is likely a rare effect but may occur for those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated. However it should be noted that there are no documented cases of seizures occurring with this compound. | ||
}} | }} | ||
{{effects/visual| | {{effects/visual| | ||
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}} | }} | ||
===Combination effects=== | ===Combination effects=== | ||
*'''[[Cannabis]]''' - Cannabis majorly amplifies the sensory and cognitive effects of 4-HO-MiPT. This should be used with extreme caution, especially if one is not experienced with psychedelics. This interaction can also amplify the [[anxiety]], [[confusion]] and [[delusion]] producing aspects of cannabis significantly. Those who choose to use this combination are advised to start off with only a fraction of their usual cannabis dose, and slow down the pace of their normal intake considerably. | *'''[[Cannabis]]''' - Cannabis majorly amplifies the sensory and cognitive effects of 4-HO-MiPT. This should be used with extreme caution, especially if one is not experienced with psychedelics. This interaction can also amplify the [[anxiety]], [[confusion]] and [[delusion]] producing aspects of cannabis significantly. Those who choose to use this combination are advised to start off with only a fraction of their usual cannabis dose, and slow down the pace of their normal intake considerably. | ||
*'''[[Dissociatives]]''' - Dissociatives can enhance the geometry, euphoria, dissociation and hallucinatory effects of 4-HO-MiPT. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] while under the influence of | *'''[[Dissociatives]]''' - Dissociatives can enhance the geometry, euphoria, dissociation and hallucinatory effects of 4-HO-MiPT. Dissociative-induced [[Visual_disconnection#Holes.2C_spaces_and_voids|holes, spaces, and voids]] while under the influence of 4-HO-MiPT can result in significantly more vivid visuals than dissociatives alone, along with more intense [[internal hallucinations]], [[confusion]], [[nausea]], [[delusions]] and chances of a [[psychosis|psychotic reaction]]. | ||
*'''[[Benzodiazepines]]''' - Depending on the dosage, benzodiazepines can slightly to completely reduce the intensity of the cognitive, physical and visual effects of a miprocin trip. They can be very efficient at largely stopping or mitigating a [[bad trip]] at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose, however, due to the very high addiction potential that benzodiazepines possess. | *'''[[Benzodiazepines]]''' - Depending on the dosage, benzodiazepines can slightly to completely reduce the intensity of the cognitive, physical and visual effects of a miprocin trip. They can be very efficient at largely stopping or mitigating a [[bad trip]] at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose, however, due to the very high addiction potential that benzodiazepines possess. | ||
*'''[[Psychedelics]]''' - When used in combination with other psychedelics, the physical, cognitive and visual effects of each substance intensify and synergize strongly with each other. The synergy between those substances is unpredictable, and for this reason, is generally not advised. If choosing to combine psychedelics, it is recommended to start with lower dosages than one would take for either substance individually. | *'''[[Psychedelics]]''' - When used in combination with other psychedelics, the physical, cognitive and visual effects of each substance intensify and synergize strongly with each other. The synergy between those substances is unpredictable, and for this reason, is generally not advised. If choosing to combine psychedelics, it is recommended to start with lower dosages than one would take for either substance individually. | ||
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{{#ask: [[Category:4-HO-MiPT]][[Category:Experience]]|format=ul|Columns=1}} | {{#ask: [[Category:4-HO-MiPT]][[Category:Experience]]|format=ul|Columns=1}} | ||
Additional experience reports can be found here: | Additional experience reports can be found here: | ||
* [https://www.erowid.org/experiences/subs/exp_4HOMiPT.shtml Erowid Experience Vaults: 4-HO-MiPT] | |||
*[https://www.erowid.org/experiences/subs/exp_4HOMiPT.shtml Erowid Experience Vaults: 4-HO-MiPT] | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== | ||
4-HO-MiPT is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating. | 4-HO-MiPT is [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with use. It is most often self-regulating. | ||
Tolerance to the effects of 4-HO-MiPT | Tolerance to the effects of 4-HO-MiPT is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-MiPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-MiPT all psychedelics will have a reduced effect. | ||
===Dangerous interactions=== | ===Dangerous interactions=== | ||
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==Legal status== | ==Legal status== | ||
{{legalStub}} | {{legalStub}} | ||
*'''Brazil''': As of August 21, 2018, 4-HO-MiPT has been added to Portaria SVS/MS nº 344. Possession, distribution and use of this substance is now considered illegal.<ref>{{cite web|url=http://portal.anvisa.gov.br/lista-de-substancias-sujeitas-a-controle-especial|title=Lista de substâncias sujeitas a controle especial no Brasil|access-date=August 27, 2020|publisher=Agência Nacional de Vigilância Sanitária (ANVISA) [Brazilian Health Regulatory Agency]|language=pt}}</ref> | *'''Brazil''': As of August 21, 2018, 4-HO-MiPT has been added to Portaria SVS/MS nº 344. Possession, distribution and use of this substance is now considered illegal.<ref>{{cite web|url=http://portal.anvisa.gov.br/lista-de-substancias-sujeitas-a-controle-especial|title=Lista de substâncias sujeitas a controle especial no Brasil|access-date=August 27, 2020|publisher=Agência Nacional de Vigilância Sanitária (ANVISA) [Brazilian Health Regulatory Agency]|language=pt}}</ref> | ||
*'''Germany''': 4-HO-MiPT is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MiPT are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref> | *'''Germany''': 4-HO-MiPT is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-MiPT are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref> | ||
*'''Japan''': 4-HO-MiPT is a controlled substance in Japan effective March 25th, 2015.<ref>{{cite web|url=https://www.mhlw.go.jp/stf/houdou/0000078803.html|title=危険ドラッグの成分16物質を新たに指定薬物に指定|publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)]|access-date=May 2, 2022|language=ja}}</ref> | |||
*'''Poland''': 4-HO-MiPT is a NPS class drug in Poland, making it illegal to possess or distribute.<ref>{{cite web|title=Rozporządzenie Ministra zdrowia z dnia 21 sierpnia 2019 r. zmieniające rozporządzenie w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych|url=http://prawo.sejm.gov.pl/isap.nsf/download.xsp/WDU20190001745/O/D20191745.pdf|language=pl|date=August 21, 2019|publisher=Sejm Rzeczypospolitej Polskiej [Sejm of the Republic of Poland]}}</ref> | *'''Poland''': 4-HO-MiPT is a NPS class drug in Poland, making it illegal to possess or distribute.<ref>{{cite web|title=Rozporządzenie Ministra zdrowia z dnia 21 sierpnia 2019 r. zmieniające rozporządzenie w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych|url=http://prawo.sejm.gov.pl/isap.nsf/download.xsp/WDU20190001745/O/D20191745.pdf|language=pl|date=August 21, 2019|publisher=Sejm Rzeczypospolitej Polskiej [Sejm of the Republic of Poland]}}</ref> | ||
*'''Sweden''': 4-HO-MiPT is classified as a health hazard under the act ''Lagen om förbud mot vissa hälsofarliga varor'' (translated as the "Act on the Prohibition of Certain Goods Dangerous to Health") as of November 1, 2005, making it illegal to sell or possess.<ref>{{cite web|title=Svensk författningssamling Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor|url=http://www.notisum.se/rnp/sls/sfs/20050733.pdf|id=SFS 2005:733|language=sv|date=October 6, 2005|publication-date=October 18, 2005|}}</ref> | *'''Sweden''': 4-HO-MiPT is classified as a health hazard under the act ''Lagen om förbud mot vissa hälsofarliga varor'' (translated as the "Act on the Prohibition of Certain Goods Dangerous to Health") as of November 1, 2005, making it illegal to sell or possess.<ref>{{cite web|title=Svensk författningssamling Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor|url=http://www.notisum.se/rnp/sls/sfs/20050733.pdf|id=SFS 2005:733|language=sv|date=October 6, 2005|publication-date=October 18, 2005|}}</ref> | ||
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==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Psychedelics]] | *[[Psychedelics]] | ||
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*[[Hallucinogens]] | *[[Hallucinogens]] | ||
*[[Psilocin]] (''4-HO-DMT'') | *[[Psilocin]] (''4-HO-DMT'') | ||
*[[4-AcO-DMT]] | *[[4-AcO-DMT]] | ||
==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/4-HO-MiPT 4-HO-MiPT (Wikipedia)] | *[https://en.wikipedia.org/wiki/4-HO-MiPT 4-HO-MiPT (Wikipedia)] | ||
*[https://erowid.org/chemicals/4_ho_mipt/4_ho_mipt.shtml 4-HO-MiPT (Erowid Vault)] | *[https://erowid.org/chemicals/4_ho_mipt/4_ho_mipt.shtml 4-HO-MiPT (Erowid Vault)] | ||
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===Discussion=== | ===Discussion=== | ||
*[http://www.bluelight.org/vb/threads/154051-The-Big-amp-Dandy-4-HO-MiPT-Thread-Part-1 4-HO-MiPT (Bluelight)] | *[http://www.bluelight.org/vb/threads/154051-The-Big-amp-Dandy-4-HO-MiPT-Thread-Part-1 4-HO-MiPT (Bluelight)] | ||