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Substituted phenidates: Difference between revisions
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'''Substituted phenidates''' (also known as '''phenidates''') | [[File:Substituted_phenidate.svg|thumb|right|301px||Generic structure of a phenidate molecule.]] | ||
'''Substituted phenidates''' (also known as '''phenidates''') refer to a class of compounds that predominantly produce traditional [[stimulant]] effects when [[administered]]. A substituted phenidate may be defined as an ester of ritalinic acid and its analogs. | |||
==Chemistry== | ==Chemistry== | ||
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==Pharmacology== | ==Pharmacology== | ||
{{pharmacology}} | {{pharmacology}} | ||
Substituted phenidates primarily act as [[reuptake inhibitors]] of the [[monoamine]] [[neurotransmitters]] [[dopamine]], [[norepinephrine]], and to a | Substituted phenidates primarily act as [[reuptake inhibitors]] of the [[monoamine]] [[neurotransmitters]] [[dopamine]], [[norepinephrine]], and to a much lesser degree, [[serotonin]]. One study found that all substituted phenidates inhibited the norepinephrine and dopamine reuptake transporters 4 to >1,000-fold more potently than the serotonin transporter.<ref>{{cite journal | vauthors=((Luethi, D.)), ((Kaeser, P. J.)), ((Brandt, S. D.)), ((Krähenbühl, S.)), ((Hoener, M. C.)), ((Liechti, M. E.)) | journal=Neuropharmacology | title=Pharmacological profile of methylphenidate-based designer drugs | volume=134 | pages=133–140 | date= May 2018 | url=https://linkinghub.elsevier.com/retrieve/pii/S0028390817303878 | issn=00283908 | doi=10.1016/j.neuropharm.2017.08.020}}</ref> | ||
== List of substituted phenidates == | == List of substituted phenidates == | ||
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==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Phenethylamines]] | *[[Phenethylamines]] | ||
*[[Substituted amphetamine]] | *[[Substituted amphetamine]] | ||
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*[[Stimulants]] | *[[Stimulants]] | ||
[[Category:Phenidate]] | ==External links== | ||
* [https://en.wikipedia.org/wiki/List_of_methylphenidate_analogues List of methylphenidate analogues (Wikipedia)] | |||
==Literature== | |||
* Luethi, D., Kaeser, P. J., Brandt, S. D., Krähenbühl, S., Hoener, M. C., & Liechti, M. E. (2017). Pharmacological profile of methylphenidate-based designer drugs. Neuropharmacology. https://doi.org/10.1016/j.neuropharm.2017.08.020 | |||
==References== | |||
<references /> | |||
[[Category:Chemical class]] | |||
[[Category:Phenidate|*]] | |||