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Substituted phenidates: Difference between revisions
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'''Substituted phenidates''' (also known as '''phenidates''') | [[File:Substituted_phenidate.svg|thumb|right|301px||Generic structure of a phenidate molecule.]] | ||
'''Substituted phenidates''' (also known as '''phenidates''') refer to a class of compounds that predominantly produce traditional [[stimulant]] effects when [[administered]]. A substituted phenidate may be defined as an ester of ritalinic acid and its analogs. | |||
==Chemistry== | ==Chemistry== | ||
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==Pharmacology== | ==Pharmacology== | ||
{{pharmacology}} | {{pharmacology}} | ||
Substituted phenidates primarily act as [[reuptake inhibitors]] of the [[monoamine]] [[neurotransmitters]] [[dopamine]], [[norepinephrine]], and to a much lesser degree, [[serotonin]]. One study found that all substituted phenidates inhibited the norepinephrine and dopamine reuptake transporters 4 to >1,000-fold more potently than the serotonin transporter.<ref>Luethi, D., Kaeser, P. J., Brandt, S. D., Krähenbühl, S., Hoener, M. C., | Substituted phenidates primarily act as [[reuptake inhibitors]] of the [[monoamine]] [[neurotransmitters]] [[dopamine]], [[norepinephrine]], and to a much lesser degree, [[serotonin]]. One study found that all substituted phenidates inhibited the norepinephrine and dopamine reuptake transporters 4 to >1,000-fold more potently than the serotonin transporter.<ref>{{cite journal | vauthors=((Luethi, D.)), ((Kaeser, P. J.)), ((Brandt, S. D.)), ((Krähenbühl, S.)), ((Hoener, M. C.)), ((Liechti, M. E.)) | journal=Neuropharmacology | title=Pharmacological profile of methylphenidate-based designer drugs | volume=134 | pages=133–140 | date= May 2018 | url=https://linkinghub.elsevier.com/retrieve/pii/S0028390817303878 | issn=00283908 | doi=10.1016/j.neuropharm.2017.08.020}}</ref> | ||
== List of substituted phenidates == | == List of substituted phenidates == | ||
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*[[Entactogens]] | *[[Entactogens]] | ||
*[[Stimulants]] | *[[Stimulants]] | ||
==External links== | |||
* [https://en.wikipedia.org/wiki/List_of_methylphenidate_analogues List of methylphenidate analogues (Wikipedia)] | |||
==Literature== | ==Literature== | ||
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<references /> | <references /> | ||
[[Category:Phenidate]] | [[Category:Chemical class]] | ||
[[Category:Phenidate|*]] | |||