Talk:2F-NENDCK: Difference between revisions

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{{headerpanel|{{Approval}}}}

~~{{SummarySheet}}~~

~~[[File:2F-NENDCK_structure.png|400px]]~~

==History and culture==

{{2F-NENDCK (short for 2-fluoro-N–ethylnordeschloroketamine, also known as CanKET, 2’-fluoro-2-oxo-PCE or 2-FXE) is a novel synthetic dissociative drug was first identified in Canberra, Australia (2022) at Cantest, a legal anonymous substance testing site, Novel synthetic substances have been typically put under the category of "designer drug"

2F-NENDCK (short for 2-fluoro-N–ethylnordeschloroketamine, also known as CanKET, 2’-fluoro-2-oxo-PCE or 2-FXE) is a novel synthetic dissociative drug was first identified in Canberra, Australia (2022) at Cantest, a legal anonymous substance testing site, Novel synthetic substances have been typically put under the category of "designer drug"

CanKet (Canberra Ketamine) gained its name for its Ketamine like properties and effects.

Canket has since been discovered being manufactured in laboratory's in mainland China and Taiwan.

The original CanKet samples and many since have reportably came from sales at festivals and bush parties in the NSW mountain ranges specifically around the Brindabella mountain range.

At CanTEST, 2F-NENDCK has been found numerous times in samples that were expected to be ketamine. According to CanTEST’s final evaluation, only 57% of the 81 samples expected to be ketamine actually contained ketamine as of April 2023. The remaining 43% of the 81 samples contained other dissociative drugs, including 2F-NENDCK, 2F-DCK, and tiletamine (a veterinary dissociative anaesthetic), as well as other psychoactive and non-psychoactive compounds. According to DrugsData.org, a drug checking service in the US that analyses samples sent by mail, numerous samples sold as ketamine, FXE, 2F, MXE, 2F-DCK, and even heroin, fentanyl and ibogaine, actually contained 2F-NENDCK.}}

At CanTEST, 2F-NENDCK has been found numerous times in samples that were expected to be ketamine. According to CanTEST’s final evaluation, only 57% of the 81 samples expected to be ketamine actually contained ketamine as of April 2023. The remaining 43% of the 81 samples contained other dissociative drugs, including 2F-NENDCK, 2F-DCK, and tiletamine (a veterinary dissociative anaesthetic), as well as other psychoactive and non-psychoactive compounds. According to DrugsData.org, a drug checking service in the US that analyses samples sent by mail, numerous samples sold as ketamine, FXE, 2F, MXE, 2F-DCK, and even heroin, fentanyl and ibogaine, actually contained 2F-NENDCK.

==Chemistry==

2F-NENDCK belongs to the [https://psychonautwiki.org/wiki/Arylcyclohexylamines arylcyclohexylamines] category of substances, this category includes ketamine, PCP and other substances alike.

2F-NENDCK is remarkably simmilair to ketamine structually, it only differs in 2 points. ~~( see photo {{#l~~:image 2.png~~}} )~~

2F-NENDCK is remarkably simmilair to ketamine structually, it only differs in 2 points, 2F-NENDCK is also similar to [https://psychonautwiki.org/wiki/Fluorexetamine FXE] as it only differs in one point. [https://www.cahma.org.au/wp-content/uploads/2023/08/image.png ket/canket differences] [https://www.cahma.org.au/wp-content/uploads/2024/01/image.png canket/FXE differences] [https://chemapps.stolaf.edu/jmol/jmol.php?model=CCNC1%28CCCCC1%3DO%29C2%3DCC%3DCC%3DC2F interactive 2F-NENDCK model]

==Pharmacology==

there has been no official pharmacology or lab testing done on 2F-NENDCK

there has been no official pharmacology or lab testing done on 2F-NENDCK.

==Subjective effects==

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===~~=Effect::physical=~~===

===Physical Effects===

~~You may select physical effects to add below [[Subjective effect index#Physical effects|here]].~~

along with the list of these effects, 2F-NENDCK has also been known to produce a next day hangover, typically leaving the user feeling quite "cloudy" and "foggy".

*[https://psychonautwiki.org/wiki/Dizziness dizziness] 2F-NENDCK can have dizzy/spinning head effects in moderate dosage. some users report difficulty walking.

*[https://psychonautwiki.org/wiki/Sedation sedation] 2F-NENDCK has little sedation in lighter doses, but can induce [https://psychonautwiki.org/wiki/Ketamine ketamine] like sedation in higher doses. 2F-NENDCK's sedation is closer related to heavy [https://psychonautwiki.org/wiki/Cannabis Cannabis] couch lock.

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*[https://psychonautwiki.org/wiki/Physical_autonomy Physical autonomy] Relatively uncommon, but may occur in some users. Users may feel as if their body is performing gestures and movements outside of their own control.

===~~=Effect::visual=~~===

===Visual Effects===

====Enhancements====

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*[https://psychonautwiki.org/wiki/Acuity_suppression acuity suppression]

*[https://psychonautwiki.org/wiki/Frame_rate_suppression frame rate suppression] not to the same extent as [https://psychonautwiki.org/wiki/Ketamine ketamine], but can still be present in higher doses

*[https://psychonautwiki.org/wiki/Perspective_distortion]

*[https://psychonautwiki.org/wiki/Perspective_distortion perspective distortion]

====~~[[Effect::~~Geometry]]====

====Geometry====

there isn't much geometry hallucinatory effects, unlike [https://psychonautwiki.org/wiki/Ketamine ketamine], where users often experience, [https://psychonautwiki.org/wiki/Environmental_cubism environmental cubism], [https://psychonautwiki.org/wiki/Environmental_orbism environmental orbism], [https://psychonautwiki.org/wiki/Machinescapes machinescapes]. overall the 2F-NENDCK experience is less "deep and introspective" mentally and visually, where as [https://psychonautwiki.org/wiki/Ketamine ketamine] can often produce outer worldly perceptions and hallucinations in higher doses.

====Hallucinatory states====

there isn't a notable level of [https://psychonautwiki.org/wiki/Internal_hallucination internal] and/or [https://psychonautwiki.org/wiki/External_hallucination external hallucination] unlike [https://psychonautwiki.org/wiki/Ketamine ketamine] which has been known to have indescribable hallucinations both internally and externally.

====cognitive====

===cognitive===

You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]].

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*[https://psychonautwiki.org/wiki/Time_distortion time distortion] in higher doses it can typically induce time distortion, not to the same intensity of [https://psychonautwiki.org/wiki/Ketamine ketamine].

====auditory====

===auditory===

You may select from a list of auditory effects to add below [[Subjective effect index#Auditory effects|here]].

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*[https://psychonautwiki.org/wiki/Auditory_suppression auditory suppression]

}}

===Experience reports===

there are no notable trip reports online.

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It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance, also learn about [https://psychonautwiki.org/wiki/Responsible_drug_use responsible drug use] before using this and any psychoactive substance.

===Lethal dosage===

there has been no documented lethal ~~dose or any~~ dose for ~~that matter.~~

there has been no documented lethal dose for 2F-NENDCK.

~~The following is a rough guide for dosing ketamine as a reference (not~~ 2F-NENDCK):

~~LOW DOSE – 20-50 mg~~

~~MEDIUM DOSE – 50-125 mg~~

~~STRONG DOSE – 125-175 mg~~

~~HEAVY DOSE, POSSIBLE ANAESTHESIA – 175+ mg~~

===Tolerance and addiction potential===

===Dangerous interactions===

there has not been enough formal research into 2F-NENDCK to confidently say what the dangerous interactions are, here is the dangerous interactions for ketamine for reference.

* Alcohol - Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

* GHB / GBL - Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

* Opioids - Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

* Tramadol - Tramadol lowers the seizure threshold. Both substances increase the risk of vomiting and unconsciousness.

* Amphetamines - No unexpected interactions, though likely to increase blood pressure (likely not an issue with sensible doses). Moving around on high doses of this combination may be ill-advised due to risk of physical injury.

* Cocaine - No unexpected interactions, though likely to increase blood pressure (likely not an issue with sensible doses). Moving around on high doses of this combination may be ill-advised due to risk of physical injury.

* Benzodiazepines - Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if the user is not placed in the recovery position.

* MAOIs - MAO-B inhibitors appear to increase the potency of ketamine. MAO-A inhibitors have some negative reports associated with the combination but there isn't much information available

* Trazodone - When used as a sleep aid and taken close to that of a dose of ketamine, there is a risk of respiratory depression when high amounts of either are consumed.

* Grapefruit - Grapefruit juice significantly increases oral absorption of ketamine. This may result in the user having double the concentration of ketamine in their system compared to normal. The ketamine may also have a longer duration of effect. This likely applies to oral, sublingual, and intranasal administration.

==Legal status==

~~at the moment I can not find any hard evidence on its legality~~ in Australia ~~although as it belongs to the~~ [https://~~psychonautwiki~~.~~org~~/~~wiki~~/~~Arylcyclohexylamines arylcyclohexylamines~~] ~~category of drugs, i can only assume it isn't federally legal and i would worn anyone on possessing, distributing and purchasing this substance~~.

as of April 2024 2F-NENDCK is unscheduled in Australia. see [https://www.odc.gov.au/controlled-substances/list controlled substance list] for up to date information.

==See also==

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(List along order below)

* [https://en.wikipedia.org/wiki/SUBSTANCE SUBSTANCE (Wikipedia)]

* SUBSTANCE (Erowid Vault)

* SUBSTANCE ([''PiHKAL'' or ''TiHKAL''] / Isomer Design)

==Literature==

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==References==

* [https://en.wikipedia.org/wiki/2F-NENDCK]

* [https://en.wikipedia.org/wiki/2F-NENDCK wikipedia]

*[https://www.cahma.org.au/article/safer-using-canket/]

* [https://www.cahma.org.au/article/safer-using-canket/ cahma]

* [https://www.odc.gov.au/controlled-substances/list AUS controlled substance list]

* [https://www.vice.com/en/article/5d3jp5/scientists-discover-imitation-ketamine-on-the-market VICE]

* [https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/NPS_bulletin_2023.pdf NPS bulletin]

[[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]]

@@ Line 3: / Line 3: @@
 {{headerpanel|{{Approval}}}}
-{{SummarySheet}}
+{{SubstanceBox/2F-NENDCK}}
-{{SubstanceBox/Example}}
-[[File:2F-NENDCK_structure.png|400px]]
 ==History and culture==
-{{2F-NENDCK (short for 2-fluoro-N–ethylnordeschloroketamine, also known as CanKET, 2’-fluoro-2-oxo-PCE or 2-FXE) is a novel synthetic dissociative drug was first identified in Canberra, Australia (2022) at Cantest, a legal anonymous substance testing site, Novel synthetic substances have been typically put under the category of "designer drug"
+F-NENDCK (short for 2-fluoro-N–ethylnordeschloroketamine, also known as CanKET, 2’-fluoro-2-oxo-PCE or 2-FXE) is a novel synthetic dissociative drug was first identified in Canberra, Australia (2022) at Cantest, a legal anonymous substance testing site, Novel synthetic substances have been typically put under the category of "designer drug"
 CanKet (Canberra Ketamine) gained its name for its Ketamine like properties and effects.
 Canket has since been discovered being manufactured in laboratory's in mainland China and Taiwan.
 The original CanKet samples and many since have reportably came from sales at festivals and bush parties in the NSW mountain ranges specifically around the Brindabella mountain range.
-At CanTEST, 2F-NENDCK has been found numerous times in samples that were expected to be ketamine. According to CanTEST’s final evaluation, only 57% of the 81 samples expected to be ketamine actually contained ketamine as of April 2023. The remaining 43% of the 81 samples contained other dissociative drugs, including 2F-NENDCK, 2F-DCK, and tiletamine (a veterinary dissociative anaesthetic), as well as other psychoactive and non-psychoactive compounds. According to DrugsData.org, a drug checking service in the US that analyses samples sent by mail, numerous samples sold as ketamine, FXE, 2F, MXE, 2F-DCK, and even heroin, fentanyl and ibogaine, actually contained 2F-NENDCK.}}
+At CanTEST, 2F-NENDCK has been found numerous times in samples that were expected to be ketamine. According to CanTEST’s final evaluation, only 57% of the 81 samples expected to be ketamine actually contained ketamine as of April 2023. The remaining 43% of the 81 samples contained other dissociative drugs, including 2F-NENDCK, 2F-DCK, and tiletamine (a veterinary dissociative anaesthetic), as well as other psychoactive and non-psychoactive compounds. According to DrugsData.org, a drug checking service in the US that analyses samples sent by mail, numerous samples sold as ketamine, FXE, 2F, MXE, 2F-DCK, and even heroin, fentanyl and ibogaine, actually contained 2F-NENDCK.
 ==Chemistry==
 F-NENDCK belongs to the [https://psychonautwiki.org/wiki/Arylcyclohexylamines arylcyclohexylamines] category of substances, this category includes ketamine, PCP and other substances alike.
-F-NENDCK is remarkably simmilair to ketamine structually, it only differs in 2 points. ( see photo {{#l:image 2.png}} )
+F-NENDCK is remarkably simmilair to ketamine structually, it only differs in 2 points, 2F-NENDCK is also similar to [https://psychonautwiki.org/wiki/Fluorexetamine FXE] as it only differs in one point.  [https://www.cahma.org.au/wp-content/uploads/2023/08/image.png ket/canket differences] [https://www.cahma.org.au/wp-content/uploads/2024/01/image.png canket/FXE differences] [https://chemapps.stolaf.edu/jmol/jmol.php?model=CCNC1%28CCCCC1%3DO%29C2%3DCC%3DCC%3DC2F interactive 2F-NENDCK model]
 ==Pharmacology==
 {{pharmacology}}
-there has been no official pharmacology or lab testing done on 2F-NENDCK
+there has been no official pharmacology or lab testing done on 2F-NENDCK.
 ==Subjective effects==
@@ Line 25: / Line 25: @@
 {{effects/base}}
-====Effect::physical====
+===Physical Effects===
-You may select physical effects to add below [[Subjective effect index#Physical effects|here]].
+along with the list of these effects, 2F-NENDCK has also been known to produce a next day hangover, typically leaving the user feeling quite "cloudy" and "foggy".
 *[https://psychonautwiki.org/wiki/Dizziness dizziness] 2F-NENDCK can have dizzy/spinning head effects in moderate dosage. some users report difficulty walking.
 *[https://psychonautwiki.org/wiki/Sedation sedation] 2F-NENDCK has little sedation in lighter doses, but can induce [https://psychonautwiki.org/wiki/Ketamine ketamine] like sedation in higher doses. 2F-NENDCK's sedation is closer related to heavy [https://psychonautwiki.org/wiki/Cannabis Cannabis] couch lock.
@@ Line 43: / Line 42: @@
 *[https://psychonautwiki.org/wiki/Physical_autonomy Physical autonomy] Relatively uncommon, but may occur in some users. Users may feel as if their body is performing gestures and movements outside of their own control.
-====Effect::visual====
+===Visual Effects===
 ====Enhancements====
@@ Line 53: / Line 52: @@
 *[https://psychonautwiki.org/wiki/Acuity_suppression acuity suppression]
 *[https://psychonautwiki.org/wiki/Frame_rate_suppression frame rate suppression] not to the same extent as [https://psychonautwiki.org/wiki/Ketamine ketamine], but can still be present in higher doses
-*[https://psychonautwiki.org/wiki/Perspective_distortion]
+*[https://psychonautwiki.org/wiki/Perspective_distortion perspective distortion]
-====[[Effect::Geometry]]====
+====Geometry====
 there isn't much geometry hallucinatory effects, unlike [https://psychonautwiki.org/wiki/Ketamine ketamine], where users often experience, [https://psychonautwiki.org/wiki/Environmental_cubism environmental cubism], [https://psychonautwiki.org/wiki/Environmental_orbism environmental orbism], [https://psychonautwiki.org/wiki/Machinescapes machinescapes]. overall the 2F-NENDCK experience is less "deep and introspective" mentally and visually, where as [https://psychonautwiki.org/wiki/Ketamine ketamine] can often produce outer worldly perceptions and hallucinations in higher doses.
 ====Hallucinatory states====
 there isn't a notable level of [https://psychonautwiki.org/wiki/Internal_hallucination internal] and/or [https://psychonautwiki.org/wiki/External_hallucination external hallucination] unlike [https://psychonautwiki.org/wiki/Ketamine ketamine] which has been known to have indescribable hallucinations both internally and externally.
-====cognitive====
+===cognitive===
 You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]].
@@ Line 79: / Line 78: @@
 *[https://psychonautwiki.org/wiki/Time_distortion time distortion] in higher doses it can typically induce time distortion, not to the same intensity of [https://psychonautwiki.org/wiki/Ketamine ketamine].
-====auditory====
+===auditory===
 You may select from a list of auditory effects to add below [[Subjective effect index#Auditory effects|here]].
@@ Line 86: / Line 85: @@
 *[https://psychonautwiki.org/wiki/Auditory_suppression auditory suppression]
-}}
-}}
 ===Experience reports===
 there are no notable trip reports online.
@@ Line 94: / Line 92: @@
 It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance, also learn about [https://psychonautwiki.org/wiki/Responsible_drug_use responsible drug use] before using this and any psychoactive substance.
 ===Lethal dosage===
-there has been no documented lethal dose or any dose for that matter.
+there has been no documented lethal dose for 2F-NENDCK.
-The following is a rough guide for dosing ketamine as a reference (not 2F-NENDCK):
-LOW DOSE – 20-50 mg
-MEDIUM DOSE – 50-125 mg
-STRONG DOSE – 125-175 mg
-HEAVY DOSE, POSSIBLE ANAESTHESIA – 175+ mg
 ===Tolerance and addiction potential===
 ===Dangerous interactions===
 {{DangerousInteractions}}
 {{DangerousInteractions/Intro}}
+there has not been enough formal research into 2F-NENDCK to confidently say what the dangerous interactions are, here is the dangerous interactions for ketamine for reference.
+* Alcohol - Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
+* GHB / GBL - Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
+* Opioids - Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
+* Tramadol - Tramadol lowers the seizure threshold. Both substances increase the risk of vomiting and unconsciousness.
+* Amphetamines - No unexpected interactions, though likely to increase blood pressure (likely not an issue with sensible doses). Moving around on high doses of this combination may be ill-advised due to risk of physical injury.
+* Cocaine - No unexpected interactions, though likely to increase blood pressure (likely not an issue with sensible doses). Moving around on high doses of this combination may be ill-advised due to risk of physical injury.
+* Benzodiazepines - Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if the user is not placed in the recovery position.
+* MAOIs - MAO-B inhibitors appear to increase the potency of ketamine. MAO-A inhibitors have some negative reports associated with the combination but there isn't much information available
+* Trazodone - When used as a sleep aid and taken close to that of a dose of ketamine, there is a risk of respiratory depression when high amounts of either are consumed.
+* Grapefruit - Grapefruit juice significantly increases oral absorption of ketamine. This may result in the user having double the concentration of ketamine in their system compared to normal. The ketamine may also have a longer duration of effect. This likely applies to oral, sublingual, and intranasal administration.
 ==Legal status==
 {{LegalStub}}
-at the moment I can not find any hard evidence on its legality in Australia although as it belongs to the [https://psychonautwiki.org/wiki/Arylcyclohexylamines arylcyclohexylamines] category of drugs, i can only assume it isn't federally legal and i would worn anyone on possessing, distributing and purchasing this substance.
+as of April 2024 2F-NENDCK is unscheduled in Australia. see [https://www.odc.gov.au/controlled-substances/list controlled substance list] for up to date information.
 ==See also==
@@ Line 119: / Line 119: @@
 (List along order below)
 * [https://en.wikipedia.org/wiki/SUBSTANCE SUBSTANCE (Wikipedia)]
-* SUBSTANCE (Erowid Vault)
-* SUBSTANCE ([''PiHKAL'' or ''TiHKAL''] / Isomer Design)
 ==Literature==
@@ Line 129: / Line 127: @@
 ==References==
 <references />
-* [https://en.wikipedia.org/wiki/2F-NENDCK]
+* [https://en.wikipedia.org/wiki/2F-NENDCK wikipedia]
-*[https://www.cahma.org.au/article/safer-using-canket/]
+* [https://www.cahma.org.au/article/safer-using-canket/ cahma]
+* [https://www.odc.gov.au/controlled-substances/list AUS controlled substance list]
+* [https://www.vice.com/en/article/5d3jp5/scientists-discover-imitation-ketamine-on-the-market VICE]
+* [https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/NPS_bulletin_2023.pdf NPS bulletin]
 [[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]]